Transgenic Core Facility

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Publications Documenting Core Expertise

  1. Weiler-Guettler H, Christie PD, Beeler DL, Healy AM, Hancock WW, Rayburn H, Edelberg JM, Rosenberg RD: A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J. Clin. Invest. 101, 1983-1991 (1998)
  2. Conway, E.M., Pollefeyt, S., Cornellisen, J., DeBaere, I., Steiner-Mosonyi, M., Weitz, J.I., Weiler-Guettler, H., Carmeliet, P., and Collen, D.: Structure-function analyses of thrombomodulin by gene-targeting in mice: The cytoplasmic domain is not required for normal fetal development. Blood (1999) 93: 3442-3450
  3. Lu J, Chang P, Richardson JA, Gan L, Weiler H, Olson EN :The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis. Proc. Natl. Acad. Sci. USA (2000) 97:9525-9530.
  4. Zhao, R., Fahs, S., Weiler, H, Duncan, S.: An efficient method to successively introduce transgenes into a given genomic locus in the mouse BMC Developmental Biology 2001, 1:10
  5. Isermann, B, Hendrickson, S.B., Zogg, M., Wing, M., Cummiskey, M., Kisanuki, Y.Z., Yanagisawa, M., and Weiler, H.: Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis. J. Clin. Invest. (2001) 108: 537–546.
  6. Miano, J.M., Kitchen, C.M., Chen, J., Maltby, K.M., Kelly, L.A., Weiler, H., Krahe, R., Ashworth, L.K., Garcia, E.: Expression of human smooth muscle calponin in transgenic mice revealed with a bacterial artificial chromosome. Am. J. Physiol. Heart Circ. Physiol. (2002) 282: H1793-H1803.
  7. Conway, E.M., van de Wouwer, M., Pollefeyt, S., Jurk, K., van Aken, H., Weitz, J., Weiler, H., Hellings, P, Schaeffer, P., Herbert, J.M., Collen, D, Theilmeier, G.. The lectin-like domain of thrombomodulin confers protection from neutrophil-mediated tissue damage by suppressing adhesion molecule expression via NFkB and MAP kinase pathways. (2002) J. Exp. Med. 196, 565–577 (2002).
  8. Miano JM, Ramanan N, Georger MA, de Mesy-Bentley KL, Emerson RL, Balza RO, Xiao Q, Weiler H, Ginty DD and Misra RP. Restricted inactivation of serum response factor to the cardiovascular system. Proc. Natl. Acad. Sci. USA 101: 17132-17137 (2004)
  9. Durham JT, Brand OM, Arnold M, Reynolds JG, Muthukumar L, Weiler H, Richardson JA, Naya FJ. Myospryn is a direct transcriptional target for MEF2A that encodes a striated muscle, alpha -actinin interacting, costamere localized protein. J. Biol. Chem. 281: 6841-6849 (2006)
  10. Qizhen Shi, David A Wilcox, Scot A Fahs, Hartmut Weiler, Clive Wells, Brian C Cooley, Drashti Desai1, Patricia A Morateck, Jack Gorski & Robert R Montgomery. Factor VIII ectopically targeted to platelets is therapeutic in hemophilia A with high-titer inhibitory antibodies. J. Clin. Invest. 116: 1974-1982 (2006)
  11. Isermann B, Vinnikov IA, Madhusudhan T, Herzog SUE, Kashif M, Blautzik J, Corat MAF, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP. Activated Protein C protects against diabetic nephropathy by inhibiting glucose induced endothelial and podocyte apoptosis. Nat. Med. 13: 1349-1358 (2007)
  12. Qizhen Shi, Scot A. Fahs, David A. Wilcox, Erin L. Kuether, Patricia A. Morateck, Nicole Mareno, Hartmut Weiler, and Robert R. Montgomery Syngeneic transplantation of hematopoietic stem cells (HSC) that are genetically modified to express factor VIII (FVIII) in platelets restores hemostasis to hemophilia A mice with pre-existing FVIII immunity. Blood (2008) Oct 1;112(7):2713-21
  13. Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, Kwitek AE, Lernmark A, Gorski J, Weiler H. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liver failure in mice lacking gimap5. Blood (2008) Dec 15; 112(13): 4905-14
  14. Mosesson MW, Cooley BC, Hernandez I, Diorio JP, Weiler H. Thrombosis risk modification in transgenic mice containing the human fibrinogen thrombin-binding gamma' chain sequence. J Thromb Haemost. 7: 102-110 (2009)
  15. Geurts AM, Cost GJ, Freyvert Y, Zeitler B, Miller JC, Choi VM, Jenkins SS, Wood A, Cui X, Meng X, Vincent A, Lam S, Michalkiewicz M, Schilling R, Foeckler J, Kalloway S, Weiler H, Ménoret S, Anegon I, Davis GD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Jacob HJ, Buelow R. Knockout rats via embryo microinjection of zinc-finger nucleasesScience. 2009 Jul 24;325(5939):433.
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