Amadou Camara, PhD, and Ranjan Dash, PhD, awarded $2 million NIH grant
Dr. Amadou KS Camara, PhD, Associate Professor of the Department of Anesthesiology, and Dr. Ranjan K Dash, PhD, Associate Professor of the Department of Physiology and the Biotechnology and Bioengineering Center, have jointly been awarded a R01 grant from the National Heart Lung and Blood Institute (NHLBI) of the National Institutes of Health, entitled “Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart”, in the amount of $2,102,000 for a duration of four years.
This project is aimed at mechanistically determining how therapies may be targeted at the molecular level to improve mitochondrial function in the heart with ischemic or ischemia-reperfusion injury. Drs. Camara and Dash plan on developing an integrative research program combining experimental measurements and computational modeling of mitochondrial function with an overall goal of quantifying the biophysics and chemical kinetics associated with mitochondrial handling of pH, cations, and reactive oxygen species (ROS) in cardiac myocytes under normal and ischemic conditions. The proposed research will determine how functional defects in the kinetics of mitochondrial cation transport (influx and efflux) and buffering and mitochondrial generation and scavenging of ROS affect overall mitochondrial function in heart cells during ischemia and ischemia-reperfusion injury.