David F. Stowe, MD, PhD
Professor of Anesthesiology and Physiology
Adjunct Professor of Biomedical Engineering
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
Dr. David Stowe received his PhD from Michigan State University and his MD from the Medical College of Wisconsin. He completed a Postdoctoral Fellowship with the Cardiovascular Research Institute at the University of California - San Francisco. Dr. Stowe's Residency training was completed in the Department of Anesthesiology at the Medical College of Wisconsin.
Dr. Stowe is dedicated to conducting research on how to protect the heart against ischemia reperfusion injury. This includes the effects of age, hypothermia, ischemic and pharmacologic preconditioning (volatile anesthetics, adenosine, other cardiotonic agents), sodium hydrogen and sodium calcium exchange inhibitors, and cardioplegic formulations on electrophysiology, contractility, vascular reactivity, reactive species formation, ion fluxes, metabolism and tissue damage. Dr. Stowe's laboratory also investigates the assessment of mitochondrial bioenergetics (respiration, inner membrane potential, redox potential, hydrogen, potassium and calcium flux, reactive oxygen species) by drugs, hypothermia, ischemia and toxic injury in isolated hearts, isolated cardiac cells, and isolated mitochondria.
Other ongoing research includes the measure of endothelial function and vascular reactivity in isolated hearts, isolated rings, and isolated cells. In these tissues and cells the effects of hypothermia on reactive oxygen species generation and scavenging capability are examined. Current laboratory activities also focus on cardiac modeling of actinomyosin calcium relationships, conduction and dysrhythmias, and mitochondrial bioenergetics (matrix hydrogen, potassium and calcium flux, redox state, respiration, and reactive oxygen species).
To contact Dr. Stowe, please call 414-456-5722 or e-mail email@example.com.