Hsiang-En Wu, MD
Assistant Professor of Anesthesiology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
Chronic pain affects a high percentage of the population in modern societies (15-25%) with a prevalence associated positively with older age, female and lower socioeconomic and educational status. There is a widely accepted consensus that current treatments for neuropathic pain are unsatisfactory. Although numerous triggers have been proposed for initiating neuropathic pain, including sympathetic nervous system influences, interruption of neurotrophin transport, and activation of inflammatory cascades, none has been established as a clinically relevant pathway. Sigma receptor activation is an exciting, novel, and plausible mechanism that has not been explored. Understanding the contributions of σR in primary sensory neurons to neuropathic pain may provide a new therapeutic pathway for this poorly treated debilitating condition.
My current interest and research focus is to link subcellular events to behavior through pharmacologic, electrophysiological and molecular studies of σR in neuropathic pain. Future studies will also explore σR contributions to the poor efficacy of opioid analgesia in neuropathic pain, as well as opioid tolerance and addiction. Currently, I am working with my mentor, Dr. Quinn Hogan, and his colleagues, Dr. Sarantopoulos and Bruce McCallum. I am also collaborating with Dr. Sengupta (Dept. Medicine) and Dr. Stucky (Dept. Cell Biology, Neurobiology & Anatomy) in pain research.
To contact Dr. Wu, please call 414-456-5663 or e-mail email@example.com.