Translational Science will be explored through team-based learning with class discussion of assigned cases. At the end of the course, the students will describe and analyze the use of appropriate clinical and translational research techniques, evidence based medicine and outcomes research methods, identify gaps between basic science knowledge and clinical practice for specific clinical questions pertinent to their area of research, propose the steps needed to apply basic science knowledge to outline possible experiments that are feasible and compliant with regulatory and ethical issues and identify significant clinical questions/hypotheses that would benefit from translational research programs. Translational Science will be explored through team-based learning with class discussion of assigned cases. At the end of the course, the students will describe and analyze the use of appropriate clinical and translational research techniques, evidence based medicine and outcomes research methods, identify gaps between basic science knowledge and clinical practice for specific clinical questions pertinent to their area of research, propose the steps needed to apply basic science knowledge to outline possible experiments that are feasible and compliant with regulatory and ethical issues and identify significant clinical questions/hypotheses that would benefit from translational research programs.
Doctor of Philosophy
Qualified medical students may be admitted into a program leading to the acquisition of both a PhD and MD degree.
Admission to the Biochemistry Graduate Program is through the Interdisciplinary Program in Biomedical Sciences. After completion of the first year curriculum of that program, students who choose to complete their dissertation work with faculty of the Biochemistry Department will have the opportunity to continue their graduate studies by selecting from among a wide range of courses that are offered within the Biochemistry Department as well as other programs at MCW. Courses to be taken are based on the student's interests in consultation with the student's dissertation committee.
Prerequisites: Biochemistry of the Cell 16202
Biochem 02222A: Protein Chemistry: August 17 - December 21, 2009 3 Semester Hours
With complete sequences for the genomes of human and many other species now available, much of the attention in molecular biological research is rapidly turning to the characterization of organism-wide collections of gene products, often referred to as functional gemnomics or proteomics. Just as the human genome project catalyzed generational advancement in DNA sequencing technology, current trends demand improved methods for efficient cloning, production and physical characterization of recombinant proteins. With the changing nature of protein characterization in mind, this course will focus on the practical aspects of protein production and characterization, including the steps most commonly encountered in the development of strategies for three-dimensional structural characterization by NMR or x-ray crystallography. New methods and optimization of standard approaches for high-throughput applications will be emphasized, including techniques ranging from chromatography and electrophoresis to mass spectrometry, fluorescence and NMR spectroscopy.