Interdisciplinary Program in Biomedical Sciences

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Interdisciplinary Program Faculty

Antholine, William E., PhD

EPR spectroscopy to determine the ligation of metals in (primarily, copper) proteins and complex biological systems

Long, Roy M., PhD

RNA localization in yeast

Auchampach, John A., PhD

Molecular and functional characterization of receptors for the endogenous nucleoside adenosine and the potential for cardiac regeneration following myocardial infarction using embryonic stem cells

Lough, John W., PhD

Cell and molecular biology of early heart development

Ma, Yan-Qing, PhD

Molecular mechanisms of integrin activation

Barbieri, Joseph T., PhD

Mechanisms of Bacterial Toxin Action

Battle, Michele, PhD

Transcriptional control of liver and gut development and physiology

Malherbe, Laurent, PhD

Regulation of CD4 T cell immunity following vaccination and infection

Benjamin, Ivor, MD

How cells respond to stress is a fundamental property underlying proteostasis, specialized functions (e.g., contraction/relaxation), and disease onset and/or progression. Our laboratory focuses on the cellular mechanisms related to redox biology and mitochondrial function in protein misfolding and related cardiac disorders using complementary models systems such as genetically engineered rodents and human induced pluripotent stem (iPS) cells.

McNally, Mark T., PhD

RNA processing (splicing and polyadenylation) in cells and viruses

Besharse, Joseph C., PhD

Cellular and molecular basis or circadian rhythmicity; the cellular basis of membrane turnover in retinal photoreceptors

Blank, Robert, MD, PhD

My laboratory studies the genetics of bone biomechanical performance and vertebral patterning. Endothelin converting enzyme is a strong candidate gene for a quantitative trait locus for bone size and strength we identified in previous work. This has led us to study of endothelin biology in greater detail. As a consequence, we are now also engaged in vascular and reproductive biology as well as bone biology.

Bloom, Alan S., PhD

Mechanisms and sites of action in the human brain of cocaine, nicotine and marijuana

Mirza, Shama, PhD

Profiling protein signatures in glioblastoma multiforme with differential response to bevacizumab (anti-VEGF) therapy useful for early diagnosis and better prognosis of the disease and to identify new therapeutic targets for individualized treatment

Campbell, William B., PhD

Regulation of vascular tone and adrenal steroidogenesis by endothelial factors

Misra, Ravi, PhD

Transcriptional control and signaling during epicardial and early coronary vascular development

Carroll, Joseph, PhD

Structure-function relationships in the human retina, high-resolution retinal imaging, mechanisms of retinal degeneration

Myers, Charles R., PhD

Elucidation of the role of cytochromes and other electron-transporting proteins in reductive metal metabolism

Chen, Guan, PhD

Mechanisms by which Ras induces p38gamma expression and by which p38gamma is required for Ras-induced transformation/invasion

Newman, Debra K., PhD

Signal transduction in platelets and leukocytes, thrombosis, non-receptor tyrosine kinases and phosphatases

Chen, Yi-Guang, PhD

Immunogenetics of Type 1 Diabetes

Newman, Peter J., PhD

Cell adhesion and signaling in blood and vascular cells

Chrzanowska-Wodnicka, Magdalena, PhD, FAHA

We study function of small GTPases in the cardiovascular system using cell biology, biochemistry and in vivo approaches

Olsen, Christopher, PhD

Brain mechanisms in drug and non-drug addictive behavior

Cirillo, Lisa A., PhD

Molecular mechanisms underlying liver development and function, with a particular focus on the role played chromatin structure in the translational regulation of liver genes

Park, Jong-In, PhD

Elucidation of the innate tumor-suppressive mechanisms that activate senescence or cell death responses when oncogenic alterations occur in cells

Coburn, Jenifer, PhD

Pathogenic mechanisms of spirochetes that cause Lyme disease and leptospirosis

Pfister, Sandra L., PhD

Sex, vascular tone and arachidonic acid metabolism and thromboxane receptors in atherosclerosis

Corbett, John A, PhD

Diabetes, beta-cell biology, inflammation innate immunity, cell signaling, cell fate decisions

Pritchard, Kirkwood A., PhD

My laboratory investigates mechanisms by which vascular inflammation impairs vasodilatation and oxidative stress alters cell signaling to impair vascular function. Another major focus of my is developing novel tools/agents to inhibit key mediators of inflammation and oxidative to improve vascular function

Cui, Weiguo, PhD

Transcriptional regulation of effector and memory T cell differentiation during infection and tumorigenesis

Ramchandran, Ramani, PhD

The Developmental Vascular Biology program investigates the basic mechanisms of blood vessel formation in vertebrates and the contribution of the vasculature to disease states. In particular, vascular conditions associated with children such as hemangiomas and solid tumors will benefit because ongoing studies in this program utilize developing zebrafish and mouse embryos.

Dahms, Nancy, PhD

Glycobiology, lysosome biogenesis, lysosomal storage disorders, regulation of growth factor and protease activation

Rao, Sridhar, PhD

Transcriptional Regulation of Stem Cells

Dittel, Bonnie, PhD

Immune regulation of central nervous system autoimmunity

Riese, Matthew, MD/PhD

Biochemistry of inhibitory and stimulatory signal transduction in T cells and application to adoptive T cell therapies

Drobyski, William R., PhD

Immunobiology of bone marrow transplantation

Riley, Danny A., PhD

The effects of actual and simulated spaceflight uploading on neuromuscular structure and function and understanding vibration injury of tissues

Duncan, Stephen A., DPhil

Molecular mechanisms underlying mammalian development

Robinson, Richard, PhD

Cellular responses to mycobacterium tuberculosis

Dwinell, Michael B., PhD

Mucosal immunity; immune regulation in cancer

Routes, John, PhD

Our laboratory seeks to understand the etiology and optimize the treatment of the unique interstitial lung disease that occurs in patients with common variable immunodeficiency, looks to develop and implement novel assays that can be used in high-throughput population based screening to detect immunodeficiencies in newborns and to develop novel tumor vaccines that by harnessing the immunogenicity of adenovirus E1A

Ebert, Allison D., PhD

Neurodegenerative diseases, both understanding the molecular basis for the disease progression and finding effective experimental therapies

Sahoo, Daisy, PhD

Understanding HDL functionality, mechanisms that regulate the selective uptake of HDL-cholesterol and reverse cholesterol transport, the role of scavenger receptors in uptake of HDL-cholesterol, the relationship between scavenger receptor expression and changes in membrane lipids, the role of CD36 in the uptake of very long chain fatty acids

Everson, Carol A., PhD

Elucidation of the effects of sleep deficiency on metabolic, endocrine, and inflammatory processes. Discovery of the specific physical properties that account for restoration by sleep.

Salzman, Nita, PhD

Innate mucosal immunity, host-pathogen-microbiota interactions in the GI tract, the role of the intestinal microbiota in health and disease

Feix, Jimmy B., PhD

Biological and biochemical characterization of antimicrobial peptides, EPR site-directed spin labeling, and the structure and function of member proteins

Scaglione, Kenneth, PhD

Elucidation of the neuroprotective mechanisms of ubiquitin and chaperone pathways in neurodegenerative diseases

Frank, Dara W., PhD

Genetic regulation of exotoxin synthesis

Fu, Jianhua, PhD

Mechanistic study of gene transcription and its regulation in eukaryotic cells using structural and biochemical methods

Shim, Katherine, PhD

Genetic control of inner ear and olfactory system development

Gauthier, Kathryn, PhD

Effect of arachidonic acid products on smooth muscle relaxation of small resistance arteries

Sidjanin, D.J., PhD

Molecular genetics of hereditary eye disease

Gerges, Nashaat, PhD

Cellular and molecular mechanisms of synaptic plasticity

Silverstein, Roy L., PhD

We study the molecular and cellular pathogenesis of common vascular disorders, including thrombosis, atherosclerosis and cancer angiogenesis. We focus on the role of a specific cellular receptor, CD36, expressed on platelets, macrophages, capillary endothelial cells and adipocytes, using mouse models of vascular disease and in vitro models with human cells, with a particular interest in characterizing receptor-ligand interactions, intracellular signaling pathways, and genetic regulatory pathways

Girotti, Albert, PhD

Elucidation of pro-survival vs. pro-death signaling cascades in tumor cells and other mammalian cells exposed to oxidative challenges, including therapeutic challenges, with a special interest in nitric oxide-mediated pro-survival signaling

Smith, Brian, PhD

Epigenetic and redox control of protein function through post-translational modifications

Glavaski-Joksimovic, Aleksandra, PhD

Therapeutic potential of mesenchymal stem cells in brain injury and neurodegenerative disorders

Solberg Woods, Leah, PhD

My laboratory is interested in identifying novel genes involved in the development and progression of type 2 diabetes. To this end, we use an outbred rat model for fine-mapping genetic loci, followed by sequencing and expression to narrow candidate genes.

Grayson, Mitchell H., PhD

The Grayson Lab is studying how viral respiratory infections drive the development of allergic diseases, like asthma, and how the microbiome affects the respiratory immune system

Sood, Rashmi, PhD

Maternal/fetal health: Roles of coagulation and platelets in placental vascular disease and maternal hypertensive disorders of pregnancy; estrogen and coagulation cross-talk; biomarkers of pregnancy complications

Gundry, Rebekah, PhD

Interface of stem cell biology and analytical protein biochemistry to better understand pluripotent stem cells and their derivatives in context of cardiac development and disease

Sorokin, Andrey, PhD

Dr. Sorokin's research is focused on mechanisms of initiation and progression of proliferative kidney diseases. Research in his laboratory is primarily focused on 1) understanding the role of endothelin signaling in hypertension induced nephropathy and proliferative glomerulonephritis; 2) cellular regulation of prostaglandin production with an emphasis on regulation of Cox-2 activity on the level of catalysis by proteins spatially co-localized with the enzyme in its natural environment; 3) elucidation of BK virus entry pathways and prevention of polyomavirus nephropathy after renal transplantation

Strande, Jennifer L., PhD

The Strande Lab is using induced pluripotent stem cells (iPSCs) to study dystrophic cardiomyopathy, which is a type of heart failure that patients with Duchenne or Becker muscular dystrophy develop

Hessner, Martin J., PhD

Type 1 diabetes, innate immunity, autoimmunity, functional genomics

Stucky, Cheryl L., PhD

Molecules that sense touch and pain

Hill, Blake, PhD

Druggability of proteins involved in mitochondrial homeostasis in healthy and diseased cells to identify molecular mechanism and novel therapeutic routes

Hillard, Cecilia J., PhD

Biochemical mechanisms involved in the synthesis, release, and degradation of the endocannabinoids, the role of endocannabinoid signaling in the regulation of mood and responses to stress and their effects on metabolic functions in the brain

Tarakanova, Vera, PhD

Virus-host interaction: manipulation of the DNA damage response by gammaherpesviruses and herpesvirus kinases, regulation of viral chromatin, mouse models of human DNA damage response-associated diseases

Hogg, Neil, PhD

Mechanisms by which nitric oxide affects cellular functions at the level of individual protein modifications

Terhune, Scott, PhD

Human cytomegalovirus-host cell protein interactions during infection

Hyde, James S., PhD

Development of EPR instrumentation and extension of ways in which existing EPR and MRI can be used for new categories of biomedical problems

Traktman, Paula, PhD

Vaccinia virus: replication, morphogenesis, and the role of dynamic phosphorylation. VRK protein kinases: the role of the cellular VRKs in cell structure, function and proliferation

Imig, John D., PhD

Elucidation of mechanisms by which eicosanoid metabolites influence cardiovascular function

Twining, Sally, PhD

Elucidation of the role of proteinases and proteinase inhibitors in corneal wound healing and corneal ulceration and exploration of the effects of maspin in corneal wound healing and in carcinogenesis

Jackson, Vaughn, PhD

Transcription within a eukaryotic cell is not process in which RNA polymerase can freely access the DNA for either initiation or elongation of the transcript

Vasquez-Vivar, Jeannette, PhD

Superoxide generation from eNOS, regulation of NO production in the heart, and tetrahydrobiopterin in fetal brain development

Jackson, William, PhD

Viral genetics, virus-host cell interactions

Jeong, Hyeongnam (Joseph), PhD

Leveraging molecular and cellular technologies, mouse models, and clinical specimens, my research focuses on understanding signaling pathways in tumor initiation, tumor progression, and therapeutic response and resistance with particular emphasis on prostate cancer and skin cancer

Volkman, Brian, PhD

NMR and crystallographic analysis of ligand binding and conformational dynamics in chemokines and other signaling proteins; structure-based drug discovery of novel anti-metastatic compounds

Johnson, Bryon, PhD

Cancer immunotherapy and hematopoietic stem cell transplantation immunology

Wang, Demin, PhD

Study signal transduction pathways that regulate hematopoietic stem cell and B cell biology

Joksimovic, Milan, PhD

Molecular mechanisms governing development of the mammalian central nervous system

Wang, Li Lily

Immune regulation mediated by immune-checkpoint regulators; Cancer immunotherapy; cancer vaccine development

Kalyanaraman, Balaraman, PhD

Application of EPR in free radical biology and understanding the role of free radicals in signal transduction and apoptosis

Kim, Jung-Ja, PhD

Structure-function relationships of enzymes and receptors by X-ray crystallography combined with various biochemical methods

Warltier, David C., PhD

Cardioprotection (preconditioning and postconditioning) against ischemia and reperfusion injury by pharmacological agents including volatile anesthetics, neovascularization of ischemic myocardium by coronary collateral vessels, and actions of anesthetic agents and positive inotropic agents on left ventricular mechanisms in the absence and presence of disease states such as congestive heart failure

Klug, Candice, PhD

Site-directed spin labeling EPR spectroscopy technique to study the functional dynamics of bacterial membrane and retinal proteins

Kristich, Christopher J., PhD

Signal transduction and antibiotic resistance in gram-positive bacteria

Williams, Calvin B., PhD

Regulatory T cell development and function

Kwok, Wai-Meng, PhD

Electrophysiology of inherited cardiac arrhythmias; role of ion and nucleotide transport across the outer mitochondrial membrane in cardioprotection

Williams, Carol L., PhD

Biochemical signaling pathways and cellular processes regulated by the Ras and Rho families of small GTPases

Lee, Sang Hyeong, PhD

Understand the molecular and cellular mechanisms of synaptic plasticity

Wong-Riley, Margaret, PhD

Coupling of neuronal activity and energy metabolism at the cellular and molecular levels. Critical period of neurochemical and metabolic development in brain stem respiratory neurons. Photobiomodulation of neurons functionally inactivated by toxins

Levick, Scott, PhD

Interactions between sensory nerves, mast cells, and fibroblasts in the heart and the role that these interactions play in the development of heart failure

You, Ming, PhD

Identification of candidate lung cancer susceptibility genes by capture-sequencing of targeted regions or jeans and frequent somatic mutations in lung adenocarcinomas and squamous cell carcinomas by exome sequencing

Link, Brian, PhD

Genetics and cell biology of ocular development and disease

Zahrt, Thomas C., PhD

Bacterial pathogenesis and host-cell interactions

Liu, Qing-Song, PhD

Understand the mechanism of cocaine addiction

Zhu, Jeqing, PhD

Study the mechanism of receptor transmembrane signaling using structural, biochemical, and cell biology methods. Structure-based design of small molecules for disturbing receptor function.
© 2014 Medical College of Wisconsin
Page Updated 08/06/2014