2011

Khan SA, Nanduri J, Yuan G, Kinsman B, Kumar GK, Joseph J, KALYANARAMAN B, Prabhakar NR. NADPH oxidase 2 mediates intermittent hypoxia-induced mitochondrial complex I inhibition: Relevance to blood pressure changes in rats. Antioxid. Redox Signal. 14:533-542 (2011).

Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, KALYANARAMAN B, Frei B. Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem. Res. Toxicol. 24:30-34 (2011).

2010

Bartesaghi S, Wenzel J, Trujillo M, López M, Joseph J, KALYANARAMAN B, Radi R. Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. Chem. Res. Toxicol. 23:821-835 (2010).

Chacko BK, Reily C, Srivastava A, Johnson MS, Ye Y, Ulasova E, Agarwal A, Zinn KR, Murphy MP, KALYANARAMAN B, Darley-Usmar V. Prevention of diabetic nephropathy in Ins2(+/)⁻(AkitaJ) mice by the mitochondria-targeted therapy MitoQ. Biochem. J. 432:9-19 (2010).

Chandran K, McCracken J, Peterson FC, Antholine WE, Volkman BF, KALYANARAMAN B. Oxidation of histidine residues in copper-zinc superoxide dismutase by bicarbonate-stimulated peroxidase and thiol oxidase activities: Pulse EPR and NMR studies. Biochemistry 49:10616-10622 (2010).

Cheng Q, Antholine WE, Myers JM, KALYANARAMAN B, Arnér ES, Myers CR. The selenium-independent inherent pro-oxidant NADPH oxidase activity of mammalian thioredoxin reductase and its selenium-dependent direct peroxidase activities. J. Biol. Chem. 285:21708-21723 (2010).

Dasgupta J, Kar S, Liu R, Joseph J, KALYANARAMAN B, Remington SJ, Chen C, Melendez JA. Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase. J. Cell. Physiol. 225:52-62 (2010).

Diers AR, Higdon AN, Ricart KC, Johnson MS, Agarwal A, KALYANARAMAN B, Landar A, Darley-Usmar VM. Mitochondrial targeting of the electrophilic lipid 15-deoxy-Delta12,14-prostaglandin J2 increases apoptotic efficacy via redox cell signalling mechanisms. Biochem. J. 426:31-41 (2010).

Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, KALYANARAMAN B. Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free Radic. Biol. Med. 49:1674-1684 (2010).

Rao VA, Klein SR, Bonar SJ, Zielonka J, Mizuno N, Dickey JS, Keller PW, Joseph J, KALYANARAMAN B, Shacter E. The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J. Biol. Chem. 285:34447-34459 (2010).

Subramanian S, Kalyanaraman B, Migrino RQ. Mitochondrially targeted antioxidants for the treatment of cardiovascular diseases. Recent Pat. Cardiovasc. Drug Discov. 5:54-65 (2010).

Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc. Natl. Acad. Sci. USA 107:8788-8793 (2010).

Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, KALYANARAMAN B, Frei B. Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. Chem Res Toxicol. 2011 Jan 14;24(1):30-4. Epub 2010 Nov 3.

Zhu BZ, Zhu JG, Mao L, KALYANARAMAN B, Shan GQ. Detoxifying carcinogenic polyhalogenated quinones by hydroxamic acids via an unusual double Lossen rearrangement mechanism. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20686-90. Epub 2010 Nov 12.

Zielonka J, Sikora A, Joseph J, Kalyanaraman B. Peroxynitrite is the major species formed from different flux ratios of co-generated nitric oxide and superoxide: Direct reaction with boronate-based fluorescent probe. J. Biol. Chem. 285:14210-14216 (2010). 

2009

Chandran K, Aggarwal D, Migrino RZ, Joseph J, McAllister D, Konorev EA, Antholine WE, Zielonka J, Srinivasan S, Avadhani NG, KALYANARAMAN B. Doxorubicin inactivates myocardial cytochrome c oxidase in rats: Cardioprotection by mito-Q. Biophys. J. 96:1388-1398 (2009).

Galati D, Srinivasan S, Raza H, Prabu SK, Hardy M, Chandran K, Lopez M, KALYANARAMAN B, Avadhani NG. Role of nuclear-encoded subunit Vb in the assembly and stability of cytochrome c oxidase complex: Implications in mitochondrial dysfunction and ROS production. Biochem. J. 420:439-449 (2009).

Larson M, Larson M, Li Z, Larson M, Li Z, Hall CL, Jensen E, McAllister DM, KALYANARAMAN B, Zhao M. Physiological fluctuation of (99m)Tc-sestamibi uptake in normal mammary glands: A systematic investigation in female rats. Acta Radiol. 50:975-978 (2009).

Li Z, Lopez M, Hardy M, McAllister DM, KALYANARAMAN B, Zhao M. A (99m)Tc-labeled triphenylphosphonium derivative for the early detection of breast tumors. Cancer Biother. Radiopharm. 24:579-587 (2009).

Sikora A, Zielonka J, Lopez M, Joseph J, KALYANARAMAN B. Direct oxidation of boronates by peroxynitrite: Mechanism and implications in fluorescence imaging of peroxynitrite. Free Radic. Biol. Med. 47:1401-1407 (2009).

Zhang H, Andrekopoulos C, Xu Y, Joseph J, Hogg N, Feix J, KALYANARAMAN B. Decreased S-nitrosation of peptide thiols in the membrane interior. Free Radic. Biol. Med. 47:962-968 (2009).

Zhang H, Zielonka J, Sikora A, Joseph J, Xu Y, KALYANARAMAN B. The effect of neighboring methionine residue on tyrosine nitration and oxidation in peptides treated with MPO, H2O2, and NO2(-) or peroxynitrite and bicarbonate: Role of intramolecular electron transfer mechanism? Arch. Biochem. Biophys. 484:134-145 (2009).

Zhu BZ, Shan GQ, Huang CH, KALYANARAMAN B, Mao L, Du YG. Metal-independent decomposition of hydroperoxides by halogenated quinones: Detection and identification of a quinone ketoxy radical. Proc. Natl. Acad. Sci. USA 106:11466-11471(2009).

Zielonka J, Hardy M, KALYANARAMAN B. HPLC study of oxidation products of hydroethidine in chemical and biological systems: Ramifications in superoxide measurements. Free Radic. Biol. Med. 46:329-338 (2009).

2008

Bartesaghi S, Peluffo G, Zhang H, Joseph J, KALYANARAMAN B, Radi R. Tyrosine nitration, dimerization, and hydroxylation by peroxynitrite in membranes as studied by the hydrophobic probe N-t-BOX-l-tyrosine tert-butyl ester. Methods Enzymol. 441:217-236 (2008).

Janssen-Heininger YM, Mossman BT, Heintz NH, Forman HJ, KALYANARAMAN B, Finkel T, Stamler JS, Rhee SG, van der Vliet A. Redox-based regulation of signal transduction: Principles, pitfalls, and promises. Free Radic. Biol. Med. 45:1-17 (2008).

Konorev EA, Vanamala S, KALYANARAMAN B. Differences in doxorubicin-inducted apoptotic signaling in adult and immature cardiomyocytes. Free Radic. Biol. Med. 45:1723-1728 (2008).

Matsunaga T, Kamiya T, Sumi D, Kumagai Y, Kalyanaraman B. L-Xylulose reductase in involved in 9,10-phenanthrenequinone-induced apoptosis in human T lymphoma cells. Free Radic. Biol. Med. 44:1191-1202 (2008).

Bartesaghi S, Ferrer-Sueta G, Peluffo G, Valez V, Zhang H, KALYANARAMAN B, Radi R. Protein tyrosine nitration in hydrophilic and hydrophobic environments. Amino Acids 32:501-515 (2007).

Borthiry GR, Antholine WE, KALYANARAMAN B, Myers JM, Myers CR. Reduction of hexavalent chromium by human cytochrome b(5): Generation of hydroxyl radical and superoxide. Free Radic. Biol. Med. 42:738-755; discussion 735-737 (2007).

Hardy M, Chalier F, Ouari O, Finet JP, Rockenbauer A, KALYANARAMAN B, Tordo P. Mito-DEPMPO synthesized from a novel NH2-reactive DEPMPO spin trap: A new and improved trap for the detection of superoxide. Chem. Commun. (Camb.) 10:1083-1085 (2007).

Hardy M, Rockenbauer A, Vasquez-Vivar J, Felix C, Lopez M, Srinivasan S, Avadhani N, Tordo P, KALYANARAMAN B. Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. Chem. Res. Toxicol. 20:1053-1060 (2007).

Horowitz S, Binion DG, Nelson VM, Kanaa Y, Javadi P, Lazarova Z, Andrekopoulos C, KALYANARAMAN B, Otterson MF, Rafiee P. Increased arginase activity and endothelial dysfunction in human inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 292:G1323-G1336 (2007).

Kotamraju S, Williams CL, KALYANARAMAN B. Statin-induced breast cancer cell death: Role of inducible nitric oxide and arginase-dependent pathways. Cancer Res. 67:7386-7394 (2007).

Romero N, Peluffo G, Bartesaghi S, Zhang H, Joseph J, KALYANARAMAN B, Radi R. Incorporation of the hydrophobic probe N-t-BOC-l-tyrosine tert-butyl ester (BTBE) to red blood cell membranes to study peroxynitrite-dependent reactions. Chem. Res. Toxicol. 20:1638-1648 (2007).

Thomas S, Kotamraju S, Zielonka J, Harder DR, KALYANARAMAN B. Hydrogen peroxide induces nitric oxide and proteasome activity in endothelial cells: A bell-shaped signaling response. Free Radic. Biol. Med. 42:1049-1061 (2007).

Xu Y, KALYANARAMAN B. Synthesis and ESR studies of a novel cyclic nitrone spin trap attached to a phosphonium group - a suitable trap for mitochondria-generated ROS? Free Radic. Res. 41:1-7 (2007).

Zhu B-Z, KALYANARAMAN B, Jiang G-B. Molecular mechanism for metal-independent production of hydroxyl radicals by hydrogen peroxide and halogenated quinones. Proc. Natl. Acad. Sci. USA 104:17575-17578 (2007).

Zhu BZ, Zhao HT, KALYANARAMAN B, Liu J, Shan GQ, Du YG, Frei B. Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones. Proc. Natl. Acad. Sci. USA 104:3698-3702 (2007).

2006

Bartesaghi S, Valez V, Trujillo M, Peluffo G, Romero N, Zhang H, KALYANARAMAN B, Radi R. Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC L-tyrosine tert butyl ester (BTBE). Biochemistry 45:6813-6825 (2006).

Chi L, Ke Y, Luo C, Li B, Gozal D, KALYANARAMAN B, Liu R. Motor neuron degeneration promotes neural progenitor cell proliferation, migration, and neurogenesis in the spinal cords of ALS mice. Stem Cells 24:34-43 (2006). 

Huh J, Liepins A, Zielonka J, Andrekopoulos C, KALYANARAMAN B, Sorokin A. Cyclooxygenase 2 rescues LNCaP prostate cancer cells from sanguinarine-induced apoptosis by a mechanism involving inhibition of nitric oxide synthase activity. Cancer Res. 66:3726-3736 (2006).

Kotamraju S, Matalon S, Matsunaga T, Shang T, Hickman-Davis JM, KALYANARAMAN B. Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells. Free Radic. Biol. Med. 40:1034-1044 (2006).

Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, LeGoffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, KALYANARAMAN B, Darley-Usmar VM, Noguchi N. Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am. J. Pathol. 168:1737-1748 (2006).

Whitsett J, Martásek P, Zhao H, Schauer DW, Hatakeyama K, KALYANARAMAN B, Vásquez-Vivar J. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase-serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic. Biol. Med. 40:2056-2068 (2006).

Zielonka J, Sarna T, Roberts JE, Wishart JF, KALYANARAMAN B. Pulse radiolysis and steady-state analyses of the reaction between hydroethidine and superoxide and other oxidants. Arch. Biochem. Biophys. 456:39-47 (2006).

Zielonka J, Vasquez-Vivar J, KALYANARAMAN B. The confounding effects of light, sonication and Mn(III)TBAP on quantitation of superoxide using hydroethidine. Free Radic. Biol. Med. 41:1050-1057 (2006).