Biophysics

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B. Douglas Ward

Senior Biostatistician, Department of Biophysics

Department of Biophysics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
Phone: 414-955-4039
Fax: 414-955-6512
ward@mcw.edu

PubMed


Education

University of Wisconsin-Milwaukee B.S. 1989 Mathematics
University of Wisconsin-Milwaukee M.S. 1990 Mathematics

Honors

1989, Summa Cum Laude, University of Wisconsin-Milwaukee
1992-1993, Graduate School Fellowship, University of Wisconsin-Milwaukee
1993-1994, Graduate School Dissertation Fellowship, University of Wisconsin-Milwaukee
1994, Rufus P. Arndt Fellowship for Work in Applied Mathematics

Research

B.D. Ward was originally trained as an electrical engineer and was employed for seven years as an aeronautical engineer responsible for the development and evaluation of missile-guidance logic. Later he pursued graduate training in mathematics and statistics, receiving an MS in mathematics from the University of Wisconsin-Milwaukee.

In 1996, B.D. Ward joined the Biophysics Research Institute of the Medical College of Wisconsin. His responsibilities in Biophysics MRI research (specifically, fMRI research) have included AFNI software development for image processing, signal processing, statistical analysis, and display of fMRI data; documentation and maintenance of AFNI software; and statistical consulting for the fMRI research community.

In the area of image processing, Mr. Ward has developed software for automatic segmentation of the intracranial region (3dIntracranial), image intensity uniformization (3dUniformize), and automatic segmentation of subcortical structures (3dSegment).

Mr. Ward has done extensive work in the area of software development for fMRI signal detection and analysis, which includes the widely used program 3dDeconvolve for multiple regression and deconvolution analysis of fMRI data. For nonlinear regression analysis, he wrote the program 3dNLfim, which has been particularly useful for modeling of the pharmacokinetic fMRI signal. Additionally, he wrote the program 3dWavelet for wavelet analysis of fMRI time-series data. He developed each of these fMRI time-series analysis programs in two separate versions: a noninteractive batch-processing version and an interactive version for graphical display of the fitted waveforms and statistical results.

He has also developed several programs for group statistical analysis of fMRI data (i.e., combining data from multiple subjects, either as a single group or for across-group comparisons) on a voxel-by-voxel basis. For classical statistical analysis applications (which assume normality of the data), he wrote programs 3dANOVA, 3dANOVA2, and 3dANOVA3 for one-, two-, and three-factor analysis of variance, including tests for fixed and random effects, interactions, and contrasts in factor level means. He also wrote the program 3dRegAna for multiple linear regression analysis across fMRI datasets.

For nonparametric statistical analysis of group fMRI data, Mr. Ward developed the programs 3dMannWhitney (Wilcoxon rank-sum test of two groups), 3dWilcoxon (Wilcoxon signed-rank test for paired fMRI data), 3dKruskalWallis (Kruskal-Wallis test for comparing multiple treatments), and 3dFriedman (comparison of blocked multiple treatments).

To help the user determine the appropriate statistical threshold level for fMRI datasets, Mr. Ward wrote AlphaSim, which calculates the tradeoff between the individual voxel probability threshold and minimum cluster size threshold to achieve the desired overall statistical significance level. He also wrote program 3dFDR, which implements the false discovery rate method as an alternative thresholding criterion, and 3dStatClust for agglomerative hierarchical clustering of multiple parameters.

Mr. Ward's current research activities and interests include Kalman filtering for analysis of non-stationary fMRI time series, real-time fMRI data analysis for clinical applications (such as real-time mapping of the visual field), mathematical modeling of pharmacokinetic fMRI data, automatic image segmentation, and numerical calculation of the MR signal due to magnetic field perturbations arising from inhomogeneities in magnetic susceptibility at the vascular level.

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