Balaraman Kalyanaraman, PhD
Chairman and Professor of Department of Biophysics
Director of Free Radical Research Center
Department of Biophysics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
Phone: 414 456-4000
Fax: 414 456-6512
Email: balarama@mcw.edu
Recent Publications
Education:
I received my B.S. in Chemistry from the University of Madras, Madras, India, and M.S. from the Indian Institute of Technology, Bombay, India. In 1978, I received my PhD in Chemistry from the University of Alabama, Tuscaloosa, AL, USA, and postdoctoral training at the National Institutes of Environmental Sciences in Research Triangle Park, NC, USA. In 1981, I joined the Biophysics Section of the Department of Radiology at the Medical College of Wisconsin, Milwaukee, USA. In 1984, I became an Assistant Professor in the Department of Radiology. Currently, I am Professor and Chairman of the Department of Biophysics at MCW. My research interests are centered on the application of ESR in free radical biology and understanding the role of free radicals in signal transduction and apoptosis. Specific research areas are outlined below. I serve as an Associate Editor for Free Radicals in Biology and Medicine, Free Radical Research, and Biochemical Journal.
Research Team:
Associate Professors, Postdocs and Research Associates:
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Joy Joseph, PhD
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Hao Zhang, PhD
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Jacek Zielonka, PhD
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Marcos Lopez, PhD
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Nir Weizman, PhD
Laboratory Technician:
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Chris Andrekopoulos, BS
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Guangying Xu, MS
Research Interests:
Chemistry and Biophysics
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Detection of free radicals by EPR spin-trapping, fluorescence, optical stopped-flow, and HPLC techniques
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Syntheses of mitochondrially-targeted spin traps, spin labels, and ROS-specific fluorescence probes
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EPR/ENDOR/NMR studies of active site geometry of redox-active enzymes (e.g. superoxide dismutase)
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Nitration of tyrosine- and tryptophan-containing peptides and protein (e.g. synucleins) in biological membranes
Mechanism of Signal Transduction/Cell Signaling
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Nitric oxide and cyclic nucleotide-dependent cell signaling and proteasomal activation
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Oxidant-induced iron signaling and apoptosis
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Redox proteomics
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Chemotherapeutic drug toxicity and prevention (e.g. doxorubicin); mechanism of apoptosis in tumor cells and normal cells
Mechanism of Diseases
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Role of mitochondria-derived oxidants in chemically-induced Parkinsonism (e.g. MPTP, rotenone) in cell culture and animal models; Mechanism of protein aggregation, proteosomal dysfunction, and apoptotic neuronal cell death
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Oxidative stress and apoptosis induced by amyotrophic lateral sclerosis (Lou Gehrig's disease)/SOD1 mutants in cell culture and animal models; Therapeutic intervention of disease progression in G93A-transgenic animal model
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