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Selected Publications 

Candice S. Klug


Rice, A.J., Alvarez, F.J.D, Schultz, K.M., KLUG, C.S., Davidson, A.L., Pinkett, H.W.  (2013) EPR Spectroscopy of MolB2C2-A Reveals Mechanism of Transport for a Bacterial Type II Molybdate Importer. J. Biol. Chem. 288, 21228-21235.     **JBC Paper of the Week

Schultz, K.M., Feix, J.B., Klug, C.S.  (2013) Disruption of LptA oligomerization and affinity of the LptA-LptC interaction. Protein Sci. 22, 1639-1645.

Dellisanti, C.D., Ghosh, B., Hanson, S.M., Raspanti, J.M., Grant, V.A., Diarra, G.M., Schuh, A.M., Satyshur, K., Klug, C.S., Czajkowski, C. (2013) Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. PLoS Biol. 11, e1001714.


Merten, J.A., Schultz, K.M., Klug, C.S.  (2012)  Concentration-dependent oligomerization and oligomeric arrangement of LptA.  Protein Sci. 21, 211-218.

Francis, D.J., Hubbell, W.L., Klug, C.S.   Probing Protein Secondary Structure using EPR:  Investigating a Dynamic Region of Visual Arrestin. Appl. Magn. Reson.  43, 405-419.


Schultz (Westfahl), K.W., Merten, J.A., KLUG, C.S.  (2011)Effects of the L511P and D512G mutations on the E. coli ABC transporter MsbA.  Biochemistry 50, 2594-2602

Schultz (Westfahl), K.W., Merten, J.A., KLUG, C.S.  (2011)  Characterization of the E506Q and H537A dysfunctional mutants in the ABC transporter MsbA.  Biochemistry 50: 3599-3608

Vishnivetskiy, S.A., Gimenez, L.E., Francis, D.J., Hanson, S.M., Hubbell, W.L., KLUG, C.S., Gurevich, V.V. (2011)  Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins. J. Biol. Chem. 286, 24288-24299.


Impellitteri NA, Merten JA, Bretscher LE, Klug CS. Identification of a functionally important loop in Salmonella typhimurium ArnT. Biochemistry 49:29-35 (2010).

Vishnivetskiy SA, Francis D, Van Eps N, Kim M, Hanson SM, KLUG CS, Hubbell WL, Gurevich VV. The role of arrestin alpha-helix I in receptor binding. J. Mol. Biol. 395:42-54 (2010).


Bretscher LE, Buchaklian AH, Klug CS. Spin-labeled lipid A. Anal. Biochem. 382:129-131 (2008).

Ferrante A, Anderson MW, Klug CS, Gorski J. HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available. PLoS ONE 3:e3277 (2008).

Hanson SM, Dawson ES, Francis DJ, Van Eps N, Klug CS, Hubbell WL, Meiler J, Gurevich VV. A model for the solution structure of the rod arrestin tetramer. Structure 16:924-934 (2008).

Klug CS, Feix JB. Methods and applications of site-directed spin labeling EPR spectroscopy. Methods Cell Biol. 84:617-658 (2008).

Orelle C, Ayvaz T, Everly RM, Klug CS, Davidson AL. Both maltose-binding protein and ATP are required for nucleotide-binding domain closure in the intact maltose ABC transporter. Proc. Natl. Acad. Sci. USA 105:12837-12842 (2008).

Westfahl KM, Merten JA, Buchaklian AB, Klug CS. Functionally important ATP binding and hydrolysis sites in E. coli MsbA. Biochemistry 47:13878-13886 (2009).


Hanson SM, Van Eps N, Francis DJ, Altenbach C, Vishnivetskiy SA, Klug CS, Hubbell WL, Gurevich VV. Structure and function of the visual arrestin oligomer. EMBO J. 26:1726-1736 (2007).

Hanson SM, Cleghorn WM, Francis DJ, Vishnivetskiy SA, Raman D, Song X, Nair KS, Slepak VZ, Klug CS, Gurevich VV. Arrestin mobilizes signaling proteins to the cytoskeleton and redirects their activity. J. Mol. Biol. 368:375-387 (2007).


Buchaklian AH, Klug CS. Characterization of the LSGGQ and H motifs from the Escherichia coli lipid A transporter MsbA. Biochemistry 45:12539-12546 (2006).

Wu N, Hanson SM, Francis DJ, Vishnivetskiy SA, Thibonnier M, Klug CS, Shoham M, Gurevich VV. Arrestin binding to calmodulin: A direct interaction between two ubiquitous signaling proteins. J. Mol. Biol. 364:955-963 (2006).

Bretscher LE, Morrell MT, Funk AF, KLUG CS. Purification and characterization of the L-Ara4N transferase protein ArnT from Salmonella typhimurium. Protein Express. Purif. 46:33-39 (2006).

Hanson SM, Francis DF, Vishnivetskiy SA, KLUG CS, Gurevich VV. Visual arrestin binding to microtubules involves a distinct conformational change. J. Biol. Chem. 281:9765-9772 (2006).

Hanson SM, Francis DF, Vishnivetskiy SA, Kolobova EA, Hubbell WL, KLUG CS, Gurevich VV. Differential interaction of spin labeled arrestin with inactive and active phosphorhodopsin. Proc. Natl. Acad. Sci. USA. 103:4900-4905 (2006).


Subczynski WK, Felix CC, Klug CS, Hyde JS. Concentration by centrifugation for gas exchange EPR oximetry measurements with loop-gap resonators. J. Magn. Reson. 176:244-248 (2005).

Buchaklian AH, Klug CS. Characterization of the walker A motif of MsbA using site-directed spin labeling EPR spectroscopy. Biochemistry 44:5503-5509 (2005).

Klug CS, Camenisch TG, Hubbell WL, Hyde JS. Multiquantum EPR spectroscopy of spin labeled arrestin K267C at 35GHz. Biophys. J. 88:3641-3647 (2005).


Austermuhle MI, Hall JA, Klug CS, Davidson AL. Maltose binding protein is open in the catalytic transition state for ATP hydrolysis during maltose transport. J. Biol. Chem. 279:28243-28250 (2004).

Buchaklian AH, Funk AL, Klug CS. The resting state conformation of the MsbA homodimer as studied by site-directed spin labeling. Biochemistry 43:8600-8606 (2004).


Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palezewski K. Calcium-sensitive regions of GCAPI as observed by chemical modifications, fluorescence, and EPR spectroscopies. J. Biol. Chem. 276:43361-43373 (2001).
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