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Selected Publications


Yu L, Vásquez-Vivar J, Jiang R, Luo K, Derrick M, Tan S. Developmental susceptibility of neurons to transient tetrahydrobiopterin insufficiency and antenatal hypoxia-ischemia in fetal rabbits. Free Radic Biol Med. 2014 Feb;67:426-36. doi: 10.1016/j.freeradbiomed.2013.11.026. Epub 2013 Dec 4.  PMID:24316196  [PubMed - in process]


Whitsett J, Rangel Filho A, Sethumadhavan S, Celinska J, Widlansky M, Vasquez-Vivar J.  Human endothelial dihydrofolate reductase low activity limits vascular tetrahydrobiopterin recycling. Free Radic Biol Med. 2013 Oct;63:143-50. doi: 10.1016/j.freeradbiomed.2013.04.035. Epub 2013 May 23. PMID:23707606 [PubMed - indexed for MEDLINE]


Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J.  Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. J Biol Chem. 2012;287(26):22174-82.

Drobyshevsky A, Luo K, Derrick M, Yu L, Du H, Prasad PV, Vasquez-Vivar J, Batinic-Haberle I, Tan S.  Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. J Neurosci. 2012;32(16):5500-9.

Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME.  Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):712-20. doi: 10.1161/ATVBAHA.111.227389.

Mao M, Sudhahar V, Ansenberger-Fricano K, Fernandes DC, Tanaka LY, Fukai T, Laurindo FR, Mason RP, Vasquez-Vivar J, Minshall RD, Stadler K, Bonini MG.  Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic Biol Med. 2012;52(2):427-35. 


Ge ZD, Ionova IA, Vladic N, Pravdic D, Hirata N, Vásquez-Vivar J, Pratt PF Jr, Warltier DC, Pieper GM, Kersten JR.  Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia.  Cardiovasc Res. 2011 Jul 15;91(2):340-9. Epub 2011 Mar 21.

Yu L, Derrick M, Ji H, Silverman RB, Whitsett J, Vásquez-Vivar J, Tan S.  Neuronal Nitric Oxide Synthase Inhibition Prevents Cerebral Palsy following Hypoxia-Ischemia in Fetal Rabbits: Comparison between JI-8 and 7-Nitroindazole.  Dev Neurosci. 2011 Jun 10. [Epub ahead of print]


Ionova IA, Vásquez-Vivar J, Cooley BC, Khanna AK, Whitsett J, Herrnreiter A, Migrino RQ, Ge ZD, Regner KR, Channon KM, Alp NJ, Pieper GM.  Cardiac myocyte-specific overexpression of human GTP cyclohydrolase I protects against acute cardiac allograft rejection. Am J Physiol Heart Circ Physiol. 2010 Jul;299(1):H88-96. Epub 2010 Apr 23.


Du J, Wei N, Xu H, Ge Y, VÁSQUEZ-VIVAR J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y. Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. Arterioscler. Thromb. Vasc. Biol. 29:2161-2168 (2009).

Hein TW, Singh U, VÁSQUEZ-VIVAR J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis 206:61-68 (2009).

Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, VÁSQUEZ-VIVAR J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann. Neurol. 65:209-217 (2009).

Pieper GM, Ionova IA, Cooley BC, Migrino RQ, Khanna AK, Whitsett JW, VÁSQUEZ-VIVAR J. Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independent of changes in nitric oxide and iNOS dimerization. J. Pharmacol. Exp. Ther. 329:890-899 (2009).

Rabbani ZN, Spasojevic I, Zhang X, Moeller BJ, Haberle S, VÁSQUEZ-VIVAR J, Dewhirst MW, Vujaskovic Z, Batinic-Haberle I. Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic. Biol. Med. 47:992-1004 (2009).

VÁSQUEZ-VIVAR J. Tetrahydrobiopterin, superoxide, and vascular dysfunction. Free Radic. Biol. Med. 47:1108-1119 (2009).

VÁSQUEZ-VIVAR J, Whitsett J, Derrick M, Ji X, Yu L, Tan S.  Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. Ann. Neurol. 66:323-331 (2009).


Ionova IA, VÁSQUEZ-VIVAR J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 295:H2178-H2187 (2008).

VÁSQUEZ-VIVAR J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM. Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. Free Radic. Biol. Med. 45:994-1001 (2008).

Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, VÁSQUEZ-VIVAR J, Avadhani NG, Kalyanaraman B. Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers. Free Radic. Biol. Med. 44:835-846 (2008).

Zielonka J, VÁSQUEZ-VIVAR J, Kalyanaraman B. Detection of 2-hydroxyethidium in cellular systems: A unique marker product of superoxide and hydroethidine. Nat. Protoc. 3:8-21 (2008).


Hardy M, Rockenbauer A, VÁSQUEZ-VIVAR J, Felix C, Lopez M, Srinivasan S, Avadhani N, Tordo P, Kalyanaraman B. Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. Chem Res Toxicol. 20:1053-1060 (2007).

Whitsett J, Picklo MJ Sr, VÁSQUEZ-VIVAR J. 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. Arterioscler. Thromb. Vasc. Biol. 27:2340-2347 (2007).


Whitsett J, Martásek P, Zhao P, Schauer DW, Hatakeyama K, Kalyanaraman B, VÁSQUEZ-VIVAR J. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase–serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic. Biol. Med. 40:2056-2068 (2006).


Pieper GM, Nilakantan V, Halligan NLN, Khanna AK, Hilton G, VÁSQUEZ-VIVAR J. Nitric oxide formation in acutely-rejecting cardiac allografts correlates with GTP cyclohydrolase I activity. Biochem. J. 391:541-547 (2005).

Porter R, Jáchymová M, Martásek P, Kalyanaraman B, VÁSQUEZ-VIVAR J. Reductive activation of Cr(VI) by nitric oxide synthase. Chem. Res. Toxicol. 18:864-843 (2005).

Zhao H, Fales HM, Sokoloski EA, Levine RL, VÁSQUEZ-VIVAR J, Kalyanaraman B. Structural characterization of the fluorescent marker product of hydroethidine and superoxide: Intracellular detection and quantitation by HPLC and limitations of fluorescent detection. Proc. Natl. Acad. Sci. USA 102:5727-5732 (2005); erratum in Proc. Natl. Acad. Sci. USA 102:9086 (2005).


Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, VÁSQUEZ-VIVAR J. Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide: A role for GFRP? Free Radic. Biol. Med. 38:481-491 (2004).


VÁSQUEZ-VIVAR J, Kalyanaraman B, Martásek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: Enzymology and physiological implications. Free Radic. Res. 37:121-127 (2003).

Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, VÁSQUEZ-VIVAR J, Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 34:1359-1368 (2003).
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