Selected Publications

2012

Sethumadhavan S, Vasquez-Vivar J, Migrino RQ, Harmann L, Jacob HJ, Lazar J.  Mitochondrial DNA variant for complex I reveals a role in diabetic cardiac remodeling. J Biol Chem. 2012;287(26):22174-82.

Drobyshevsky A, Luo K, Derrick M, Yu L, Du H, Prasad PV, Vasquez-Vivar J, Batinic-Haberle I, Tan S.  Motor deficits are triggered by reperfusion-reoxygenation injury as diagnosed by MRI and by a mechanism involving oxidants. J Neurosci. 2012;32(16):5500-9.

Wang J, Alexanian A, Ying R, Kizhakekuttu TJ, Dharmashankar K, Vasquez-Vivar J, Gutterman DD, Widlansky ME.  Acute exposure to low glucose rapidly induces endothelial dysfunction and mitochondrial oxidative stress: role for AMP kinase. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):712-20. doi: 10.1161/ATVBAHA.111.227389.

Mao M, Sudhahar V, Ansenberger-Fricano K, Fernandes DC, Tanaka LY, Fukai T, Laurindo FR, Mason RP, Vasquez-Vivar J, Minshall RD, Stadler K, Bonini MG.  Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway. Free Radic Biol Med. 2012;52(2):427-35. 

2011

2010

2009

Du J, Wei N, Xu H, Ge Y, VÁSQUEZ-VIVAR J, Guan T, Oldham KT, Pritchard KA Jr, Shi Y. Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I. Arterioscler. Thromb. Vasc. Biol. 29:2161-2168 (2009).

Hein TW, Singh U, VÁSQUEZ-VIVAR J, Devaraj S, Kuo L, Jialal I. Human C-reactive protein induces endothelial dysfunction and uncoupling of eNOS in vivo. Atherosclerosis 206:61-68 (2009).

Ji H, Tan S, Igarashi J, Li H, Derrick M, Martásek P, Roman LJ, VÁSQUEZ-VIVAR J, Poulos TL, Silverman RB. Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy. Ann. Neurol. 65:209-217 (2009).

Pieper GM, Ionova IA, Cooley BC, Migrino RQ, Khanna AK, Whitsett JW, VÁSQUEZ-VIVAR J. Sepiapterin decreases acute rejection and apoptosis in cardiac transplants independent of changes in nitric oxide and iNOS dimerization. J. Pharmacol. Exp. Ther. 329:890-899 (2009).

Rabbani ZN, Spasojevic I, Zhang X, Moeller BJ, Haberle S, VÁSQUEZ-VIVAR J, Dewhirst MW, Vujaskovic Z, Batinic-Haberle I. Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. Free Radic. Biol. Med. 47:992-1004 (2009).

VÁSQUEZ-VIVAR J. Tetrahydrobiopterin, superoxide, and vascular dysfunction. Free Radic. Biol. Med. 47:1108-1119 (2009).

VÁSQUEZ-VIVAR J, Whitsett J, Derrick M, Ji X, Yu L, Tan S.  Tetrahydrobiopterin in the prevention of hypertonia in hypoxic fetal brain. Ann. Neurol. 66:323-331 (2009).

2008

Ionova IA, VÁSQUEZ-VIVAR J, Whitsett J, Herrnreiter A, Medhora M, Cooley BC, Pieper GM. Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 295:H2178-H2187 (2008).

VÁSQUEZ-VIVAR J, Whitsett J, Ionova I, Konorev E, Zielonka J, Kalyanaraman B, Shi Y, Pieper GM. Cytokines and lipopolysaccharides induce inducible nitric oxide synthase but not enzyme activity in adult rat cardiomyocytes. Free Radic. Biol. Med. 45:994-1001 (2008).

Zielonka J, Srinivasan S, Hardy M, Ouari O, Lopez M, VÁSQUEZ-VIVAR J, Avadhani NG, Kalyanaraman B. Cytochrome c-mediated oxidation of hydroethidine and mito-hydroethidine in mitochondria: Identification of homo- and heterodimers. Free Radic. Biol. Med. 44:835-846 (2008).

Zielonka J, VÁSQUEZ-VIVAR J, Kalyanaraman B. Detection of 2-hydroxyethidium in cellular systems: A unique marker product of superoxide and hydroethidine. Nat. Protoc. 3:8-21 (2008).

2007

Hardy M, Rockenbauer A, VÁSQUEZ-VIVAR J, Felix C, Lopez M, Srinivasan S, Avadhani N, Tordo P, Kalyanaraman B. Detection, characterization, and decay kinetics of ROS and thiyl adducts of mito-DEPMPO spin trap. Chem Res Toxicol. 20:1053-1060 (2007).

Whitsett J, Picklo MJ Sr, VÁSQUEZ-VIVAR J. 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation. Arterioscler. Thromb. Vasc. Biol. 27:2340-2347 (2007).

2006

Whitsett J, Martásek P, Zhao P, Schauer DW, Hatakeyama K, Kalyanaraman B, VÁSQUEZ-VIVAR J. Endothelial cell superoxide anion radical generation is not dependent on endothelial nitric oxide synthase–serine 1179 phosphorylation and endothelial nitric oxide synthase dimer/monomer distribution. Free Radic. Biol. Med. 40:2056-2068 (2006).

2005

Pieper GM, Nilakantan V, Halligan NLN, Khanna AK, Hilton G, VÁSQUEZ-VIVAR J. Nitric oxide formation in acutely-rejecting cardiac allografts correlates with GTP cyclohydrolase I activity. Biochem. J. 391:541-547 (2005).

Porter R, Jáchymová M, Martásek P, Kalyanaraman B, VÁSQUEZ-VIVAR J. Reductive activation of Cr(VI) by nitric oxide synthase. Chem. Res. Toxicol. 18:864-843 (2005).

Zhao H, Fales HM, Sokoloski EA, Levine RL, VÁSQUEZ-VIVAR J, Kalyanaraman B. Structural characterization of the fluorescent marker product of hydroethidine and superoxide: Intracellular detection and quantitation by HPLC and limitations of fluorescent detection. Proc. Natl. Acad. Sci. USA 102:5727-5732 (2005); erratum in Proc. Natl. Acad. Sci. USA 102:9086 (2005).

2004

Kalivendi S, Hatakeyama K, Whitsett J, Konorev E, Kalyanaraman B, VÁSQUEZ-VIVAR J. Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide: A role for GFRP? Free Radic. Biol. Med. 38:481-491 (2004).

2003

VÁSQUEZ-VIVAR J, Kalyanaraman B, Martásek P. The role of tetrahydrobiopterin in superoxide generation from eNOS: Enzymology and physiological implications. Free Radic. Res. 37:121-127 (2003).

Zhao H, Kalivendi S, Zhang H, Joseph J, Nithipatikom K, VÁSQUEZ-VIVAR J, Kalyanaraman B. Superoxide reacts with hydroethidine but forms a fluorescent product that is distinctly different from ethidium: Potential implications in intracellular fluorescence detection of superoxide. Free Radic. Biol. Med. 34:1359-1368 (2003).