Biophysics

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Magnetic Resonance Biophysics

Biophysics 03230: Nuclear Magnetic Resonance (3 semester hours; Dr. Shi-Jiang Li)

This course is designed as an introduction to nuclear magnetic resonance spectroscopy (MRS). Emphasis will be placed on modern MRS techniques and their application to structural determinations of biomolecules. Imaging-guided in vivo spectroscopy and its applications to biomedicine will also be introduced.

Biophysics 03238: Magnetic Resonance Imaging (3 semester hours; Dr. Andrzej Jesmanowicz)

<Syllabus>

This course focuses on the physics of modern MRI. It will take a classical approach to spin physics and will focus on pulse sequences, k-space analysis, and hardware. An understanding of calculus is required. Biophysics 03240: Fourier Transforms is required prior to taking this course.

Biophysics 03239: Functional MRI Contrast Mechanisms and Applications (3 semester hours;  L. Tugan Muftuler, PhD ) (Prerequisite: Biophysics 03238)

The use of MRI to evaluate tissue function will be described. The course will be dedicated to discussing fMRI methods that use both endogenous contrast (labeled water, deoxygenated blood) and exogenous (injectable) MR contrast agents to image tissue function. The theory and physiology necessary for understanding MR contrast mechanisms, together with the practical knowledge necessary for performing MR experiments, will be discussed. Demonstrations of fMRI experiments will be included.

Biophysics 03240: Fourier Transforms (3 semester hours)

This course provides basic knowledge for students who will continue to study EPR or NMR. Material will cover the theory of Fourier transforms, digital transforms, NMR images, reconstruction, pulse spectroscopy methods, and electrical signal processing. An understanding of calculus and tensor vectors is recommended.

 


Molecular Biophysics

Biophysics 03222: Biophysical Techniques in Biochemistry (3 semester hours; Dr. Candice Klug)

This course will introduce the basic theory and practical applications of an array of biophysical techniques commonly used in biochemical research. Optical and magnetic spectroscopies, x-ray crystallography, and kinetics techniques are just a sampling of the topics covered in this comprehensive course.

Biophysics 03223: Electron Spin Resonance (3 semester hours; Dr. Brian Bennett)

The aim of the course is to introduce the theory and practical applications of modern EPR spectroscopy. Basic EPR theory, biological free-radical spectroscopy, relaxation and motional phenomena, spin labeling, and transition-metal EPR are among the topics covered.

Biophysics 03251: Free Radicals in Biology (3 semester hours; Dr. Neil Hogg)

Topics to be discussed include the nature of free radicals; radical initiation, propagation, and termination; free-radical reactions of biological interest; and the role of free radicals in physiological and pathological processes.

 


Common Courses

Biophysics 03295: Readings and Research (1 to 9 credits)

Biophysics 03298: Biophysics Journal Club (1 semester hour; rotating faculty)

Selected papers in theory, practice, and application of EPR and NMR spectroscopy will be read and discussed in separate sessions.

Biophysics 03300: Seminar (1 semester hour)

Weekly invited seminar speakers present their research on molecular biophysics or MRI topics.

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