Professor John Klein joined the Division of Biostatistics in the summer of 1993 coming from the Ohio State University where he was Professor of Statistics and Preventive Medicine. He was formerly the Statistical Director of The Ohio State University Comprehensive Cancer Center. He is an elected member of the International Statistical Institute and a Fellow of the American Statistical Association. Dr. John Klein has authored over 160 papers, many on statistical methods. His text Survival Analysis: Statistical Methods for Censored and Truncated Data, 2nd Edition with Professor Moeschberger is a standard textbook on survival analysis. His research is in the areas of survival analysis, competing risks, and multistate modeling.
Dr. Klein's other research interest include probabilistic models for cancer and the metastatic process, graphical association models for longitudinal data and techniques for the design and analysis of clinical trials. These techniques have been applied, for example, to transplant data, to data from the Framingham Heart Study and to data from the Danish Breast Cancer Cooperative Group. His research is funded by grants from the National Cancer Institute. Professor Klein is the statistical director of the Center for International Blood and Bone Marrow Transplant Research. He is a statistical advisor to the National Marrow Donor Program. He is a co-investigator on projects with the Department of Emergency Medicine, Orthopedics, the Center for human Genetics, and the School of Engineering at Marquette University.
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Arora, M., Klein, J.P., Weisdorf, D.J., Hassebroek, A., Flowers, M.E., Cutler, C.S., Urbano-Ispizua, A., Antin, J.H., Bolwell, B.J., Boyiadzis, M., Cahn, J.Y., Cairo, M.S., Isola, L., Jacobsohn, D.A., Jagasia, M., Klumpp, T.R., Lee, S.J., Petersdorf, E.W., Santarone, S., Gale, R.P., Schouten, H.C., Spellman, S., Wingard, J.R., Horowitz, M.M., Pavletic, S.Z. (2011). Chronic GVHD risk score: A center for international blood and marrow transplant research analysis. Blood, 117(24), 6714-6720. PMC3123030
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Ballen, K.K., Klein, J.P., Pedersen, T.L., Bhatla, D., Duerst, R., Kurtzberg, J., Lazarus, H.M., Lemaistre, C.F., McCarthy, P., Mehta, P., Palmer, J., Setterholm, M., Wingard, J.R., Joffee, S., Parsons, S.K., Switzer, G.E., Lee, S.J., Rizzo, J., Majhail, N. S. (2011). Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 2011 Nov 4. [Epub ahead of print]
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Eapen, M., Klein, J.P., Sanz, G.F., Spellman, S., Ruggeri, A., Anasetti, C., Brown, M., Champlin, R.E., Garcia-Lopez, J., Hattersely, G., Koegler, G., Laughlin, M.J., Michel, G., Nabhan, S.K., Smith, F.O., Horowitz, M.M., Gluckman, E., Rocha, V., for the Eurocord-European Group for Blood and Marrow Transplantation, Netcord, and the Center for International Blood and Marrow Transplant Research. (2011). Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukaemia and myelodysplastic syndrome: a retrospective analysis. The Lancet Oncology, 2011 Dec; 12(13), 1214-1221. PMC3245836
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Gorelick, M. H., McLellan, S. L., Wagner, D., & Klein, J. (2011). Water use and acute diarrhoeal illness in children in a united states metropolitan area. Epidemiology and Infection, 2011 Feb; 139(2), 295-301.
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Grossberg, S. E., Oger, J., Grossberg, L. D., Gehchan, A., & Klein, J. P. (2011). Frequency and magnitude of interferon beta neutralizing antibodies in the evaluation of interferon beta immunogenicity in patients with multiple sclerosis. Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research, 2011 Mar; 31(3), 337-344 [Epub ahead of print]
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Jacobsohn, D.A., Arora, M., Klein, J.P., Hassebroek, A., Flowers, M.E., Cutler, C.S., Urbano-Ispizua, A., Bolwell, B.J., Antin, J.H., Boyiadzis, M., Cahn, J.Y., Cairo, M.S., Herzig, R.H., Isola, L.M., Klumpp, T.R., Lee, S.J., Petersdorf, E.W., Santarone, S., Gale, R.P., Schouten, H.C., Spellman, S.R., Weisdorf, D.J., Wingard,J.R., Horowitz,M.M., Pavletic, S. Z. (2011). Risk factors associated with increased nonrelapse mortality and with poor overall survival in children with chronic graft-versus-host disease. Blood, 2011 Oct 20; 118(16), 4472-4479. PMC3204914
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Klein, J.P. & Tunes da Silva, G. (2011) Cutpoint selection for discretizing a continuous covariate for generalized estimating equations. Computational Statistics & Data Analysis, 2011 Jan; 55(1), 226-235, 2011.
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Logan, B. R., Zhang, M. J., & Klein, J.P. (2011). Marginal models for clustered time-to-event data with competing risks using pseudovalues. Biometrics, 67(1), 1-7. PMC2902638
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Majhail, N. S., Bajorunaite, R., Lazarus, H.M., Wang, Z., Klein, J.P., Zhang, M.J., & Rizzo, J.D. (2011). High probability of long-term survival in 2-year survivors of autologous hematopoietic cell transplantation for AML in first or second CR. Bone Marrow Transplantation, 2011 Mar; 46(3), 385-392. PMC2978251
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Marino, S.R., Lin, S., Maiers, M., Haagenson, M., Spellman, S., Klein, J.P., Binkowski, T.A., Lee, S.J., van Besien, K. (2011). Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. Bone Marrow Transplantation, 47(2), 217-226. PMC3128239
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Moulder, J.E., Fish, B.L., Cohen, E.P., & Klein, J.P. (2011). Re: Davis et al., Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Experimental Hematology, 39(5), 521-2; author reply 522-4. [Epub ahead of print]
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von Drygalski, A., Andris, D.A., Nuttleman, P.R., Jackson, S., Klein, J., & Wallace, J.R. (2011). Anemia after bariatric surgery cannot be explained by iron deficiency alone: results of a large cohort study. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery, 2011 Mar-Apr; 7(2), 151-156.
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Woolfrey, A., Klein, J.P., Haagenson, M., Spellman, S., Petersdorf, E., Oudshoorn, M., Gajewski, J., Hale, G.A., Horan, J., Battiwalla, M., Marino, S.R., Setterholm, M., Ringden, O., Hurley, C., Flomenberg, N., Anasetti, C., Fernandez-Vina, M., Lee, S. J. (2011). HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation, 17(6), 885-892. PMC3071866