John P Klein, PhD
Professor and Director
Division of Biostatistics
Institute for Health & Society
Education: PhD Statistics-University of Missouri-Columbia, 1980
Professor John Klein joined the Division of Biostatistics in the summer of 1993 coming from the Ohio State University where he was Professor of Statistics and Preventive Medicine. He was formerly the Statistical Director of The Ohio State University Comprehensive Cancer Center. He is an elected member of the International Statistical Institute and a Fellow of the American Statistical Association. Dr. John Klein has authored over 160 papers, many on statistical methods. His text Survival Analysis: Statistical Methods for Censored and Truncated Data, 2nd Edition with Professor Moeschberger is a standard textbook on survival analysis. His research is in the areas of survival analysis, competing risks, and multistate modeling.
Dr. Klein's other research interest include probabilistic models for cancer and the metastatic process, graphical association models for longitudinal data and techniques for the design and analysis of clinical trials. These techniques have been applied, for example, to transplant data, to data from the Framingham Heart Study and to data from the Danish Breast Cancer Cooperative Group. His research is funded by grants from the National Cancer Institute. Professor Klein is the statistical director of the Center for International Blood and Bone Marrow Transplant Research. He is a statistical advisor to the National Marrow Donor Program. He is a co-investigator on projects with the Department of Emergency Medicine, Orthopedics, the Center for human Genetics, and the School of Engineering at Marquette University.
Web Appendix for Wong and Klein 2011 “Semiparametric Estimation for the Additive Inverse Gaussian Frailty Model”(PDF)
Probabilistic Models for Cancer and the Metastatic Process
Graphical Association Models for Longitudinal Data
Techniques for the Design and Analysis of Clinical Trials
Martin EF, Huang J, Xiang Q, Klein JP, Bajaj J, Saeian K. Recipient survival and graft survival are not diminished by simultaneous liver-kidney transplantation: an analysis of the united network for organ sharing database. Liver Transplantation. 2012 Aug;18(8):914-29. doi: 10.1002/lt.23440. PMC3405201
Pearce KF, Lee SJ, Haagenson M, Petersdorf EW, Norden J, Collin MP, Klein JP, Spellman SR, Lowerson SA, Davies S, Dickinson AM. Analysis of non-HLA genomic risk factors in HLA-matched unrelated donor hematopoietic cell transplantation for chronic myeloid leukemia. Haematologica. 2012 Jul;97(7):1014-9. Epub 2012 Jan 22. PMC3396672
Arora M, Klein JP, Weisdorf DJ, Hassebroek A, Flowers ME, Cutler CS, Urbano-Ispizua A, Antin JH, Bolwell BJ, Boyiadzis M, Cahn JY, Cairo MS, Isola L, Jacobsohn DA, Jagasia M, Klumpp TR, Lee SJ, Petersdorf EW, Santarone S, Gale RP, Schouten HC, Spellman S, Wingard JR, Horowitz MM, Pavletic SZ. Chronic GVHD risk score: A center for international blood and marrow transplant research analysis. Blood. 2011 Jun 16;117(24):6714-20. Epub 2011 Apr 14. PMC3123030
Ballen KK, Klein JP, Pedersen TL, Bhatla D, Duerst R, Kurtzberg J, Lazarus HM, LeMaistre CF, McCarthy P, Mehta P, Palmer J, Setterholm M, Wingard JR, Joffe S, Parsons SK, Switzer GE, Lee SJ, Rizzo JD, Majhail NS. Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2012 Jun;18(6):903-12. Epub 2011 Nov 4.
Eapen M, Klein JP, Sanz GF, Spellman S, Ruggeri A, Anasetti C, Brown M, Champlin RE, Garcia-Lopez J, Hattersely G, Koegler G, Laughlin MJ, Michel G, Nabhan SK, Smith FO, Horowitz MM, Gluckman E, Rocha V; Eurocord-European Group for Blood and Marrow Transplantation; Netcord; Center for International Blood and Marrow Transplant Research. Effect of donor-recipient HLA matching at HLA A, B, C, and DRB1 on outcomes after umbilical-cord blood transplantation for leukemia and myelodysplastic syndrome: a retrospective analysis. The Lancet Oncology. 2011 Dec;12(13):1214-21. Epub 2011 Oct 6. PMC3245836
Gorelick MH, McLellan SL, Wagner D, Klein J. Water use and acute diarrhoeal illness in children in a united states metropolitan area. Epidemiology and Infection. 2011 Feb;139(2):295-301. Epub 2010 Apr 30.
Grossberg SE, Oger J, Grossberg LD, Gehchan A, Klein JP. Frequency and magnitude of interferon beta neutralizing antibodies in the evaluation of interferon beta immunogenicity in patients with multiple sclerosis. Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research. 2011 Jan 12. [Epub ahead of print]
Jacobsohn DA, Arora M, Klein JP, Hassebroek A, Flowers ME, Cutler CS, Urbano-Ispizua A, Bolwell BJ, Antin JH, Boyiadzis M, Cahn JY, Cairo MS, Herzig RH, Isola LM, Klumpp TR, Lee SJ, Petersdorf EW, Santarone S, Gale RP, Schouten HC, Spellman SR, Weisdorf DJ, Wingard JR, Horowitz MM, Pavletic SZ. Risk factors associated with increased nonrelapse mortality and with poor overall survival in children with chronic graft-versus-host disease. Blood. 2011 Oct 20; 118(16): 4472-4479. Epub 2011 Aug 20. PMC3204914
Tunes da Silva G, Klein JP. Cutpoint selection for discretizing a continuous covariate for generalized estimating equations. Computational Statistics & Data Analysis. 2011 Jan 1; 55(1): 226-235. PMC3359021
Logan, BR, Zhang MJ, & Klein JP. Marginal models for clustered time-to-event data with competing risks using pseudovalues. Biometrics, 67(1), 1-7. PMC2902638
Majhail NS, Bajorunaite R, Lazarus HM, Wang Z, Klein JP, Zhang MJ, Rizzo JD. High probability of long-term survival in 2-year survivors of autologous hematopoietic cell transplantation for AML in first or second CR. Bone Marrow Transplantation. 2011 Mar;46(3):385-92. Epub 2010 May 17. PMC2978251
Marino SR, Lin S, Maiers M, Haagenson M, Spellman S, Klein JP, Binkowski TA, Lee SJ, van Besien K. Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. Bone Marrow Transplantation. 2012 Feb;47(2):217-26. doi: 10.1038/bmt.2011.56. Epub 2011 Mar 28. PMC3128239
Moulder JE, Fish BL, Cohen EP, & Klein JP. Re: Davis et al., Timing of captopril administration determines radiation protection or radiation sensitization in a murine model of total body irradiation. Experimental Hematology. 2011 May;39(5):521-2; author reply 522-4. Epub 2011 Feb 16.
von Drygalski, A, Andris DA, Nuttleman PR, Jackson S, Klein J, & Wallace JR. Anemia after bariatric surgery cannot be explained by iron deficiency alone: results of a large cohort study. Surgery for Obesity and Related Diseases: Official Journal of the American Society for Bariatric Surgery. 2011 Mar-Apr; 7(2), 151-156.
Woolfrey A, Klein JP, Haagenson M, Spellman S, Petersdorf E, Oudshoorn M, Gajewski J, Hale GA, Horan J, Battiwalla M, Marino SR, Setterholm M, Ringden O, Hurley C, Flomenberg N, Anasetti C, Fernandez-Vina M, Lee SJ. HLA-C antigen mismatch is associated with worse outcome in unrelated donor peripheral blood stem cell transplantation. Biology of Blood and Marrow Transplantation: Journal of the American Society for Blood and Marrow Transplantation. 2011 Jun;17(6):885-92. Epub 2010 Sep 24. PMC3071866
Barker CA, Hong S, Klein JP, Shaw P, Bredeson C, Angelina A, Rowlings P, Cahn JY, Kharfan-Dabaja M, Aljurf M, Szer J, Wood WA, Ahmed I, Gomez Almaguer D, Atsuta Y, Sanz M, Hale G, Litzow M, Pasquini MC and on behalf of the CIBMTR International Studies Committee. Radiotherapeutic techniques in allogeneic hematopoietic cell transplant. 2012 BMT Tandem Meetings, San Diego, CA, February 1-5, 2012.
Boyiadzis M, Klein JP, Arora M, Weisdorf DJ, Hassebroek A, Lee SJ, Flowers ME, Cutler CS, Urbano-Ispizua A, Antin JH, Bolwell BJ, Cahn JY, Cairo MS, Gale RP, Herzig RH, Isola LM, Jacobsohn DA, Jagasia MH, Klumpp TR, Petersdorf EW, Wingard JR, Horowitz MM, Pavletic SZ. Impact of chronic GVHD on late relapse, treatment related mortality and survival after allogeneic hematopoietic cell transplantation for hematological malignancies. 2012 BMT Tandem Meetings, San Diego, CA, February 1-5, 2012.
Brazauskas R, Klein J, Le-Rademacher J. Simulating clustered competing risks data. 2012 ENAR Spring Meeting, Washington, DC, April 1-4, 2012.
Hong S, Barker C, Klein JP, Shaw P, Bredeson C, Angelina A, Rowlings P, Cahn JY, Dabaja KM, Aljurf M, Szer J, Wood WA, Ahmed I, Gomez-Almaguer D, Atsuta Y, Pasquini MC. Trends in utilization of total body irradiation prior to hematopoietic cell transplantation worldwide. 2012 BMT Tandem Meetings, San Diego, CA, February 1-5, 2012.
Tomblyn M, Trifilio S, Chen M, Klein J, Boeckh M, Gea-Banacloche J, Szabolcs P, Bennett C, on behalf of the CIBMTR Infection and Immune Reconstitution Working Committee. Risk factors and outcomes in patients with atypical mold infection following allogeneic hematopoietic cell transplantation: A CIBMTR analysis from the infection and immune reconstitution working committee. 2012 BMT Tandem Meetings, San Diego, CA, February 1-5, 2012.
Eapen M, Klein J, Sanz G, Ruggeri A, Spellman S, Annasetti C, Garcia J, Koegler G, Laughlin M, Michel G, Nabhan S, Smith F, Horowitz M, Gluckman E, Rocha V, on behalf of Eurocord-European Group for Blood and Marrow Transplantation, Netcord and the Center for International Blood and Marrow Transplant Research. Effect of donor-recipient HLA-matching at the HLA-C locus on outcomes after unrelated cord blood transplant for leukemia. EBMT 2011, Paris, France, April 2011.
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