Division of Cardiothoracic Surgery
GRANT RESEARCH
NIH-NHLBI
12/1/2001- 11/30/2005
P.I. John E. Baker, PhD
C.I. Parvaneh Rafiee, PhD
CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
This grant determines whether protein kinases contribute to cardioprotection in chronically hypoxic rabbit and human hearts.
NIH-NHLBI
9/30/2000- 8/31/2004
P.I. John E. Baker, PhD
C.I. Parvaneh Rafiee, PhD
GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
Investigates the gene(s) responsible for adaptation to intermittent hypoxia that causes susceptibility to myocardial ischemia.
NIH/NHLBI
8/1/2001-
P.I. William M. Chilian, PhD
C.I. John E. Baker, PhD
SCOR - ISCHEMIC HEART DISEASE IN BLACKS
This is a multidisciplinary approach to investigate ischemic heart disease in African Americans.
NIH
1/1/2003-
P.I. Garrett J. Gross, PhD
C.I. John E. Baker, PhD
EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
Investigates activation of opioid receptors results in acute or delayed cardioprotection that is mediated by the mitochondrial KATP channel.
ACOSOG Z0040 - Duke University
1/7/2003 - ongoing
Principal Investiator – Mario Gasparri, MD
Co-Investigator – George Haasler, MD
A PROSPECTIVE STUDY OF THE PROGNOSTIC SIGNIFICANCE OF OCCULT METASTASES IN THE PATIENT WITH RESECTABLE NON-SMALL CELL LUNG CARCINOMA
Multicenter trial sponsored by the American College of Surgery Oncology Group. It is felt that the presence of occult metastases in pleural fluid, mediastinal lymph nodes, or bone marrow at the time of non-small cell lung carcinoma resection is associated with a worse prognosis than that predicted by conventional staging methodologies. To study this, this multi-institutional study wil enroll patients with clinical Stage I, II or IIIa non- small cell lung cancer. At surgery, pleural fluid, mediastinal lymph nodes, and bone marrow are harvested to analyze them for occult micrometastases using immunohistochemistry assays. Patients are then followed for at least five years and data collected prospectively to evaluate the relationships between occult micrometastases and various parameters including prognosis, recurrence, and overall survival.
James Gralton Memorial
1/1/2000 -
P.I.: George Haasler, MD
Co-investigators include: Cardiothoracic Surgery: George Haasler, MD (PI), Mario Gasparri, MD, G. Hossein Almassi, MD; General Surgery: Henry Pitt, MD, Dennis Blom, MD; Radiation Oncology: Roger Byhardt, MD (Committee Chair), Elizabeth Gore, MD; Neoplastic Diseases: Paul Ritch, MD, Mohammed Raheem, MD, Majed Abu-Hajir, MD; Gastroenterology: Reza Shaker, MD; Pathology: Vinod Shidham, MD
MANAGEMENT OF EARLY ESOPHAGEAL CANCER
The James Gralton Memorial Fund was established by his widow, Mary Jane, after his death from esophageal cancer in late 1998. Patients with long-term esophagitis are at high risk to develop Barrett's esophagitis, which in some patients goes on to become adenocarcinoma of the esophagus. The research that this fund helps finance focuses on 3 specific points in this disease process: 1. Dysplasia and in situ carcinoma detected during surveillance of Barrett's esophagus. 2. Early stage esophageal cancer, which is limited to the site of the primary tumor. 3. Locally advanced esophageal cancer, which involves a large primary tumor that has spread to nearby lymph nodes.
AHA Northland Affiliate
7/1/2002 - 6/30/2004
P.I. Alfred Nicolosi, MD
EFFECTS OF GADOLINIUM ON CONTRACTILE FUNCTION OF THE REGIONALLY STUNNED CANINE HEART
The Principle Investigator has previously observed that intravenous administration of gadolinium enhances recovery of regionally stunned myocardium in an in vivo canine model of ischemia-reperfusion. This research is designed to better understand the mechanisms and potential clinical applications of gadolinium's effects on regionally stunned myocardium.
Thoracic Surgery Foundation
7/1/2001 - 6/30/2004
P.I. Alfred Nicolosi, MD
EFFECTS OF STRETCH ON THE MYOPATHIC HEART
The Principle Investigator has previously observed that gadolinium blocks stretch-induced contractile dysfunction in an in vitro papillary muscle model. Dilated cardiomyopathy is associated with chronic, abnormal stretch of the heart. This research tests the hypothesis that gadolinium can restore contractile function in papillary muscles from hamsters with a dilated cardiomyopathy.
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