GANDY / DOMEN LAB
Selected Publications.
Domen J., Christensen J., Wahedi, M., Danenberg E., Gille D., Smith-Berdan, S., Fong, T. and Brown, J.. Ex vivo Expanded Cryopreserved Allogeneic Myeloid Progenitors Protect Against Lethal Invasive Aspergillosis In Neutropenic Mice. Submitted, 2007.
Whole Bone Marrow injection improves function in Congenital Cardiomyopathy in mice. Rofaiel, G., Giangiacomo, D., Nichols, M., Mao, L., Weng, J. Urashima, T., Domen, J. and Gandy, K.L. Submitted 2007.
Nigro J.J., Choi S., Gradiano J., Gandy K.L., Guerrero-Tiro L.M., Cleveland D.C. Modified Superior Repair for Supracardiac Total Anomolous Pulmonary Venous Connection in the Adult. Ann Thorac Surg. 84:312-313(2007).
Gandy KL, Hanley FL. Management of systemic venous anomalies in the pediatric cardiovascular surgery patient. Pediatric Cardiac Surgery Annual 9(1):63-74, 2006.
Domen, J., Wagers, A. and Weissman, I.L.: Hematopoietic Stem Cells, in: Stem Cells: Scientific Progress and Future Research Directions at http://stemcells.nih.gov/info/scireport/2006report.htm 2006.
Gandy KL, Burtelow M, Reddy VM, Silverman N. Myofibroblastic tumor of the heart: a very rare intracardiac tumor. J Thorac Cardiovasc Surg 130(3):888-9, 2005.
Chen BJ, Cui X, Sempowski GD, Domen J, Chao NJ.: Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 103:4344-4352, 2004.
Gandy KL, Rebeiz AG, Wang A, Jaggers JJ. Left main coronary artery-to-pulmonary artery fistula with severe aneurysmal dilatation. Ann Thorac Surg. 77(3):1081-3, 2004.
Domen, J. and Weissman I.L. HSC and other hematopoietic cells show broad resistance to chemotherapeutic agents in vivo when overexpressing BCL-2. Exp. Hematol. 31:631-639, 2003.
Reya, T., Duncan, A.W., Ailles, L., Domen, J., Scherer, D., Willert, K., Hintz, L., Nusse, R. and Weissman, I.L. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature, 429:409-414, 2003.
Gandy, K.L. Use of Hematopoietic Stem Cells to Establish Tolerance for Solid Organ Transplantation. in Clinical Bone Marrow and Stem Cell Transplantation. Ed. Kerry Atkinson. Cambridge University Press, 2003.
Mebius, R.E., Miyamoto, T., Christensen. J., Domen, J., Cupedo, T., Weissman, I.L. and Akashi, K. The fetal liver counterpart of adult common lymphoid progenitors gives rise to all lymphoid lineages, CD45+CD4+CD3- cells, as well as macrophages. J Immunol 166:6593-6601, 2001.
Gandy, KL. Tolerance Induction for Solid Organ Grafts with Donor-Derived Hematopoietic Reconstitution. Immunologic Research, 22/2-3: 147-164, 2000.
Domen, J. and Weissman, I.L. Hematopoietic stem cells need two signals to prevent apoptosis; BCL-2 can provide one of these, Kitl/c-Kit signaling the other. J Exp Med, 192:1707-1718, 2000.
Domen J., Cheshier S.H., and Weissman, I.L.. The role of apoptosis in the regulation of hematopoietic stem cells; overexpression of BCL-2 increases both their number and repopulation potential. J Exp Med, 191:253-263, 2000.
Gandy K.L., Domen, J., Aguila L. and Weissman I.L.: CD8+TCR+ and CD8+TCR- cells in whole bone marrow facilitate the engraftment of HSC across allogeneic barriers. Immunity, 11:579-590, 1999.
De Vivo I., Cui X., Domen J., Cleary M. L.: Growth stimulation of primary B cell precursors by the anti-phosphatase Sbf1. Proc Natl Acad Sci U S A 95:9471-9476, 1998.
Domen J., Gandy K. L., Weissman I. L.: Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation. Blood 91:2272-2282, 1998.
Gandy KL, Weissman IL. Tolerance of heart grafts produced in mice simultaneously reconstituted with purified allogeneic hematopoietic stem cells. Transplantation, 65:295-304, 1998.
Yuh DD, Gandy KL, Reitz BA, Hoyt G, Robbins RC. Perinatal Induction of Immunotolerance to cardiac and pulmonary allografts. J Thorac Cardiovasc Surg. 114 (1): 64-75, 1997.
Yuh DD, Gandy KL, Morris RE, Hoyt G, Guttierrez J, Robbins RC. Leflunomide Prolongs Lung Allo and Xenograft Survival. J Heart Lung Transplant, 14:1136-1144, 1995.
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