Cell Biology, Neurobiology & Anatomy

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Michael Flinn

Graduate Student
Department of Cell Biology, Neurobiology & Anatomy

 

BS, Northern Illinois University, 2009
MS, Northern Illinois University 2011

Faculty Advisor: Brian A. Link, PhD

Mailing Address:
Department of Cell Biology, Neurobiology & Anatomy
8701 Watertown Plank Road
Milwaukee, WI 53226-3548
USA

Phone: (414) 955-8509
FAX: (414) 955-6517
Email: mflinn@mcw.edu

 

 

 

 


Research Area:  Upstream regulatory elements of the Hippo signaling pathway


I graduated from Northern Illinois University in 2009 with a B.S. in Biological Sciences. Shortly after, I enrolled into the master’s program at NIU, conducting research in the Bujarski Lab. I attained an M.S. in Biological Sciences in 2011. The background of my research pertained to the translational differences regarding the p3a movement protein of the Brome Mosaic Virus, focusing on translation using either genomic or subgenomic templates.

After attaining my M.S., I enrolled into MCW’s interdisciplinary doctoral program, joining the Link lab after my first year of coursework. The Link lab is interested eye development and disease, using zebrafish as a model system. The Hippo signaling pathway, discovered originally in Drosophila, is a key pathway involved in organogenesis. Although a portion of the pathway, known as the “core kinase cassette,” has been thoroughly characterized, the upstream regulatory elements of the cassette are not fully understood. The basis of my project revolves around generating knockouts of genes implicated in the Hippo as upstream regulators, via transcription activator-like effector nuclease (TALEN) mutagenesis, in order to ascertain how the pathway is linked to retinogenesis.

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