Cardiovascular Center

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Cardiovascular Center Affiliated Faculty

 


Tom P. Aufderheide, MD
Professor of Emergency Medicine
Emergency Medicine

Phone: (414) 805-6717

• Dr. Tom Aufderheide is a Professor of Emergency Medicine with Tenure and Associate Chair of Research Affairs and Director of the NIH-funded Resuscitation Research Center in the Department of Emergency Medicine at the Medical College of Wisconsin. He is a nationally and internationally recognized researcher in the field of emergency cardiac care ...

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Ellis Avner, MD
Professor
Medicine/Pediatric Nephrology
Director, Children’s Research Institute

Phone: (414) 955-2573

Research Interests

• Basic Cellular and Molecular Pathophysiology of Polycystic Kidney Disease and it’s Complications, which include Hypertension, Heart Failure, and Stroke
• Goal is to identify the Basic Cellular Abnormalities of the Polycystic Endothelial and Epithelial Cell, and Target such Abnormalities with Specific Pharmacological Inhibitors, with the Ultimate Goal of Preventing Disease Progression and the Development of Complications

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John E. Baker, PhD, FAHA
Professor of Surgery (Cardiothoracic), Pharmacology & Toxicology
Professor of Biochemistry
Investigator, Children's Research Institute

Phone: (414) 456-8706

Research Interests

• Basic research on cardiovascular development and causes of cardiovascular diseases
• Translational Research to improve clinical outcomes following cardiac surgery
• Protection of the child’s cardiovascular system against injury from radiation

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Martin Bienengraeber, PhD
Assistant Professor
Anesthesiology, Pharmacology and Toxicology

Phone: (414) 456-5690

Research Interests

• One of my research interests revolves around the role of mitochondria as triggers and effectors in protection of the heart from ischemia and stress. We use physiological, pharmacological and molecular techniques as well as proteomics to demonstrate quantifiable alterations in mitochondrial bioenergetics and protein expression during or after exposure to volatile anesthetics.

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Zeljko J. Bosnjak, PhD
Professor
Anesthesiology  

Phone: (414) 456-5687

Research Interests

• Cellular Mechanisms of Anesthetic Action/Cellular Signal Transduction Pathways Responsible for Anesthetic-Induced Cardioprotection and the Modulation of ATP Sensitive Potassium Current in Cardiac Myocytes by Ischemia and Volatile Anesthetics / Genetic Basis for Differences in Anesthetic Response and Neuropathy and Calcium Signaling

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Ulrich Broeckel, MD
Chief and Associate Professor
Pediatrics/Genomic Pediatrics

Phone: (414) 955-2369

Research Interests

• The Broeckel lab focuses on the identification and functional evaluation of genes involved in cardiovascular diseases. We have an ongoing research project focused on left ventricular hypertrophy, myocardial infarction and coronary artery disease, end-stage renal disease, and hypertension.

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Amadou K.S. Camara, PhD
Associate Professor
Anesthesiology

Phone: (414) 456-5624

Research Interests

• Dr. Camara's recent research interests focus on the role of mitochondria (respiration, inner membrane potential, redox potential, reactive oxygen species) in cardiac preservation during hypothermic and normothermic ischemia and reperfusion in isolated cardiac cells.

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William B. Campbell, PhD
Professor and Chairman
Pharmacology/Cardiovascular Pharmacology

Phone: (414) 456-8267

Research Interests

• Research in our laboratory involves the isolation and identification of new metabolites of arachidonic acid and other endothelial mediators of vascular function.

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Michael P. Cinquegrani, MD, FACC, FSCAI
Interim Chief of Cardiovascular Medicine
Professor of Cardiovascular Medicine
Department of Medicine

Phone: (414) 456-6737

• Dr. Cinquegrani has been a member of the faculty since completing his Cardiology Fellowship in 1985 at the University of Rochester Medical Center. His principal clinical activities relate to interventional and invasive cardiology and the evaluation and treatment of patients with heart failure. Dr. Cinquegrani also has held a number of administrative positions including Interim Chief of Cardiology, Director of Cardiac Catheterization, and Director of Cardiology Fellowship Training.

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Philip S. Clifford, PhD
Professor of Anesthesiology and Physiology
Associate Dean for Postdoctoral Education
Anesthesia Research 151
Zablocki Veterans Affairs Medical Center

Phone: (414) 384-2000 ext. 41584

Research Interests

• Dr. Clifford's research interests include autonomic control of cardiovascular and respiratory function and clinical monitoring of cardiorespiratory function.

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Eric P. Cohen, MD
Professor of Medicine/Department of Medicine
Nephrology Division
Zablocki VA Hospital

Phone: (414) 384-2000, x 42825

Research Interests

• My research is centered around radiation nephropathy, experimental and clinical. This occurs in humans after radiation-based bone marrow transplant and internal radionuclide therapies. It is also a risk of accidental or terrorist radiation exposure. Mitigation of that injury and its mechanism are being tested.

Selected recent publications:

  • Cohen EP, Fish BL, Irving AA, Rajapurkar MM, Shah SV, Moulder JE. Radiation Nephropathy is not mitigated by antagonists of oxidative stress. Radiat. Res, 2009, 172:260-4.

  • Lenarczyk M, Cohen EP, Fish BL, Irving AA, Sharma M, Driscoll CD, Moulder JE. Chronic oxidative stress as a mechanism for radiation nephropathy. Radiat. Res, 2009, 171: 164-172.

  • Sieber F, Muir SA, Cohen EP, North PE, Fish BL, Irving AA, Mäder M, Moulder JE. High-Dose Selenium for the Mitigation of Radiation Injury: A Pilot Study in a Rat Model. Radiat Res, 2008, 171: 368-373.

  • Cohen EP, Irving AA, Drobyski WR, Klein JP, Passweg J, Talano JM, Juckett MB, Moulder JE. Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Radiat Oncol Biol Phys, 2008, 70: 1546-1551.

  • Cohen EP, Fish BL, Sharma M, Li XA. Moulder JE. Role of the angiotensin II type 2 receptor in radiation nephropathy Translational Research 2007, 150: 106-115.

  • Sharma M, McCarthy ET, Sharma R, Fish BL, Savin VJ, Cohen EP, Moulder JE. Arachidonic Acid metabolites mediate the radiation – induced increase in glomerular albumin permeability. Exp Biol Med, 2006, 231 (1): 99-106.

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John A. Corbett, PhD
Chairman and Professor
Biochemistry

Phone: (414) 955-8768

Research Interests

•Our laboratory is focused on determining the factors that influence the function and survival of pancreatic beta cells in the context of both type 1 and type 2 diabetes mellitus. We currently have three ongoing research programs.

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Magdalena (Chrzanowska-)Wodnicka, PhD, FAHA 
Associate Investigator 
Blood Research Institute 

 Phone: (414) 937-3890 

Research Interests

• My laboratory studies the function of small G proteins in the cardiovascular system. We use transgenic mouse and zebrafish models for in vivo studies and a variety of biochemical, molecular and microscopy approaches to interrogate signaling by small GTPases in vascular cells ex vivo

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Ranjan K. Dash, PhD
Assistant Professor
Departments of Physiology, Biotechnology and Bioengineering

Phone: (414) 955-4497

Research Interests

• Mathematical modeling and computer simulations of complex physiological systems
• Computational algorithms for data analysis and parameter estimation (optimization)
• Microcirculatory oxygen and carbon dioxide transport and exchange
• Multi-scale modeling of coupled blood-tissue solute transport and cellular energy metabolism in cardiac and skeletal muscles
• Analysis of large-scale biochemical systems: regulation of cellular energy metabolism and mitochondrial oxygen consumption in cardiac and skeletal muscles
• Mitochondrial handling of cations (Ca2+, Na+, K+, H+, Mg2+) and ROS (O2, H2O2).

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Stephen Duncan, A D. Phil. Marcus Professor in
Human & Molecular Genetics
Professor-Cell Biology, Neurobiology and Anatomy

Phone: (414) 955-8602

Research Area: Molecular mechanisms underlying mammalian development

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Ashraf El-Meanawy, PhD, MD
Assistant Professor
Medicine, Nephrology  

Phone: (414) 407-0104

Research Interests

• My laboratory is studying the genetic factors contributing to the development of a vulnerable kidney. We are focused on understanding the genes and pathways responsible for reduction in the number of the filtration units "the Nephron" at birth. Subjects borne with such reduced nephron number are at risk for developing hypertension and chronic kidney disease later in life.

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Debebe Gebremedhin, BPharm, PhD
Associate Professor
Physiology

Phone: (414) 955-7515

Research Interests

• The mission of our laboratory is to understand mechanisms regulating physiology of the cerebral circulation in health and in disease conditions. Our research interests involve functional identification and characterization of different ion channel types and second messenger systems in vascular smooth muscle cells, endothelial cells, neurons and in brain astrocytes.

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Andrew S. Greene, PhD
Professor and Director
Biotechnology and Bioengineering Center
Department of Physiology

Phone: (414) 955-8671

Research Interests: Cardiovascular Physiology, Proteomics, Systems Biology

• In a broad sense, our laboratory is attempting to understand fundamental principles of cardiovascular regulation and disease. Our research is highly collaborative and spans the areas of molecular and cellular biology, genetics, proteomics, technology development and microcirculatory experiments.

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Garrett  J. Gross, PhD
Professor
Pharmacology/Pharmacology and Toxicology

Phone: (414) 955-8627

Research Interests

• Role of sarcolemmal versus mitochondrial ATP-regulated potassium channels (KATP channels) in myocardial ischemia-reperfusion injury.

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Rebekah Gundry, PhD
Assistant Professor
Biochemistry

Phone: (414) 955-2825

Dr. Gundry welcomes MCW graduate students interested in studying in the areas of stem cell biology and mass spectrometry. Potential postdoctoral research fellows are also encouraged to communicate their interests. Collaborations with researchers in the areas of cardiac development, pluripotent stem cell biology, and secreted and plasma membrane protein biology are especially welcomed.

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Anne Hoch, DO
Associate Professor
Orthopaedic Surgery Rehabilitation

Phone: (414) 805-7461

Research Interests

• Consequences of Athletic Amenorrhea in High School and College Girls • Prevalence of Disordered Eating, Amenorrhea, Osteoporosis and Early Cardiovascular Disease among High School Girls – “Female Athlete Tetrad”

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Quinn H. Hogan, MD
Professor
Anesthesiology

Phone: (414) 456-5727

Research Interests

• Cerebral Blood Flow Regulation, Microcirculation, Oxygen Transport, Functional Hyperemia, and Effect of Anesthetic Agents
• Causes of Pain

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Howard Jacob, PhD
Professor, Physiology and Human and Molecular Genetics
Director, Human and Molecular Genetics Center
Warren Knowles Chair in Genetics
Vice Chairman for Research, Childrens' Hospital of Wisconsin

Phone: (414) 955-4887

Research Interests

• The laboratory specializes in building and implementing genomic "tools" in the whole animal. Our goal is to link genomic tools to physiology for discovering the genetic basis of disease, including end stage renal disease (rat and human), hypertension (rat), insulin dependent diabetes mellitus (rat), syndrome-X (rat), left ventricular hypertrophy, myocardial infarction (rat and human) and various cardiac malformations (human).

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Balaraman Kalyanaraman, PhD
Chair and Professor
Biophysics

Phone: (414) 456-4000

Research Interests

• Promotes and Stimulates Free Radical Research at MCW and Helps Researchers Engaged in Free Radical Research acquire NIH and other Extramural Funding
• Unique Because it is Closely Associated with an EPR Research Resource (only physical technique that can detect unambiguously free radicals in biological systems) and an MRI Facility
• Promotes Translational Research in Free Radical-mediated Diseases at MCW and Neighboring Institutes and Develops Therapeutic Interventions in Free Radical Based Disease Processes • Improves the Understanding of the Mechanism of Action of Antioxidants (i.e., agents that scavenge or inhibit free radical formation) in Human Disease

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Judy R. Kersten, MD
Professor
Cardiovascular Pharmacology

Phone: (414) 456-5802

Research Interests

• Diabetes and hyperglycemia are clear contributors to adverse outcome in patients at risk for myocardial ischemia, but the mechanisms responsible for this observation are poorly understood. Ischemic preconditioning is a powerful endogenous mechanism protecting the myocardium against infarction. Our work indicates that diabetes or hyperglycemia prevents reductions of myocardial infarct size by ischemic preconditioning.

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Theodore Kotchen, MD
Professor of Medicine, Associate Dean for Clinical Research
Department of Medicine
Division of Endocrinology, Metabolism, and Clinical Nutrition

Phone: (414) 805-8696

Research Interests

• Dr. Kotchen's research interests focus primarily on hypertension, and he is author or co-author of over 200 peer reviewed publications. Most deal with mechanisms of blood pressure control, hypertension treatment strategies, and genes of hypertension.
 

Selected Recent Publications 

  • Kotchen TA, Kotchen JM, Grim CE, Krishnaswami S, Kidambi S. Aldosterone and alterations of hypertension-related vascular function in African Americans. Amer J Hypertension, 2009, 22:319-324.

  • Martin MR, Lindquist T, Kotchen TA. Why are peer review outcomes less favorable for clinical science than for basic science grant applications? Amer J Med 121:637-641.

  • Kotchen T, Grim CE, Kotchen JM, Krishnaswami S, Yang H, Hoffmann RG, McGinely EL. Altered relationship of blood pressure to adiposity in hypertension. Amer J Hypertension, 2008, 21:284-289.

  • Kidambi S, Kotchen JM, Grim CE, Raff H, Mao J, Singh RJ, Kotchen TA. Association of adrenal steroids with hypertension and the metabolic syndrome in blacks. Hypertension, 2007, 49(part 2):704-711.

  • Kotchen TA, Lindquist T, Sostek A, Hoffmann R, Malik K, Stanfield B. Outcomes of National Institutes of Health Peer Review of Clinical Grant Applications. J Invest Med, 2006, 54:13-19.

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Wai-Meng Kwok, PhD
Professor of Anesthesiology and Pharmacology & Toxicology
Department of Anesthesiology

Phone: (414) 456-5683

Research Interests

•The overall focus of Dr. Kwok’s laboratory is the investigation of ion channel modulation in the heart. There are two major areas of research currently underway. The first major area of investigation is on identifying a volatile anesthetic interaction site on a cardiac potassium channel, IKs, and characterizing the molecular determinants that modulate anesthetic action on this channel.

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Mingyu Liang, PhD
Associate Professor
Department of Physiology

Phone: (414) 955-8539

Research Interests

• My laboratory's research interest is on understanding and integrating multiple aspects and components of physiology. Our current work is focused on studying renal, cardiovascular, and endocrine physiology and pathophysiology associated with hypertension and diabetes.

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Julian H. Lombard, PhD
Professor
Department of Physiology

Phone: (414) 955-8530

Research Interests

• Current research in this laboratory utilizes television microscopy, optical Doppler velocity measurements, oxygen microelectrodes, electrophysiological techniques and molecular biology to investigate the mechanisms by which changes in oxygen availability regulate active tone in microvessels and small resistance arteries.

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John Lough, PhD
Professor
Cell Biology, Neurobiology & Anatomy

Phone: (414) 955-8459

Research Area: Cell and molecular biology of cardiac stem cell differentiation

• Our research is focused on adult cardiac regeneration, using principles learned from previous investigation of heart development in the embryo. We are using two independent albeit complementary approaches to address this problem.

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David L. Mattson, PhD
Professor
Physiology

Phone: (414) 955-8571

Research Interests

• Studies in the Mattson laboratory examine the normal and pathophysiological regulation of renal function and arterial blood pressure. A particular emphasis is placed on the paracrine, autocrine, and hormonal regulation of renal tubular and vascular function.

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Ravi P. Misra, PhD
Professor
Biochemistry

Phone: (414) 955-8433

Research Interests

• One of the overall objectives of our research is to elucidate underlying molecular mechanisms involved in cardiac function and heart formation. Congenital cardiovascular anomalies are the most common form of human birth defect with a recorded instance of 1 per 200 live births per year in North America. There is therefore considerable interest in understanding the molecular and genetic bases of these diseases.

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Michael Mitchell, MD
Associate Professor
Surgery/Division of Cardiothoracic Surgery
Specialization: Congenital Heart Disease

Phone: (414) 266-2491

Research Interests

•The genetic and molecular etiology of congenital heart disease. We are interested in identifying genetic risk factors for congenital heart disease. We believe the ability to identify these genetic risk factors will allow us to investigate the relationship between genetic deficits and molecular pathways and clinical variability, in order to make early and accurate diagnosis. The long-term goal for this research is to improve intervention strategies and long-term outcomes for our patients.

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Diane H. Munzenmaier, PhD
Assistant Professor
Department of Physiology

Phone: (414) 955-8557

Specialization: Genomics of Cardiovascular Disease

• A major interest of our laboratory has been the role of the renin-angiotensin system in vascular growth and remodeling through two major angiotensin II receptors with opposing roles. Recent evidence from our laboratory has suggested that blockade of the AT1 receptor results in an increase in cerebral microvessel density and protection from stroke.

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Debra K. Newman, PhD
Assistant Professor
Department of Pharmacology & Toxicology and Microbiology
Investigator- Blood Research Institute
BloodCenter of Wisconsin

Phone: (414) 937-3820

Research Interests

• We study the structure and function of Platelet Endothelial Cell Adhesion Molecule (PECAM)-1, also designated CD31. PECAM-1 is a 130 kDa member of the immunoglobulin (Ig) gene superfamily that is expressed on the surfaces of cells found within the vasculature, including the endothelial cells that line blood vessels and the leukocytes (monocytes, neutrophils and certain T-cell subsets) and platelets that circulate within them.

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Paula North, MD
Professor and Chief
Pathology

Phone: (414) 266-6288

Research interests

 • Vasculogenesis and hemangioma.

 • Cell/molecular biology of vascular anomalies (developmental/acquired)

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Keith T. Oldham, MD
Professor and Chief
Pediatric Surgery

Phone: (414) 266-6550

Research Interests

• Acute Lung Injury, Shock, Sepsis, Pulmonary Injury, Cardiovascular Disease, Sickle Cell Disease, Impaired Vasodilation
• Experimental Therapeutic Treatment (D-4F) of Vascular Disease as it Relates to Heart disease and stroke

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Shailendra Patel, MD, PhD
Professor of Medicine, Department of Medicine
Division of Endocrinology, Metabolism, and Clinical Nutrition
Director of Clinical, Research and Educational efforts for the Division 

Phone: (414) 456-5645

Research Interests

Genetics, Physiology and Pathophysiology of Cholesterol Disorders, Embryonic Development

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Sandra Pfister, PhD
Associate Professor
Cardiovascular Pharmacology

Phone: (414) 456-8285

Research Interests

• Atherosclerosis is a multi-factorial disease involving a number of different cell types and mechanisms. Of particular interest is the evidence that the synthesis of thromboxane, the predominant metabolite of arachidonic acid in platelets, increases in atherosclerosis and blockade of thromboxane receptors attenuates atherosclerotic plaque formation in mice and rabbits. The current therapeutic strategy of low dose aspirin to protect against cardiovascular disease provides further evidence that thromboxane is an important component of the vascular responses in atherosclerosis since this regimen is designed to selectively inhibit platelet thromboxane production. Despite this, the exact role of thromboxane in the development and progression of atherosclerosis is not well understood.

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Kirkwood A. Pritchard, PhD
Professor and Vice Chair, Research
Pediatric Surgery

Phone: (414) 955-5615

• Acute Lung Injury, Shock, Sepsis, Pulmonary Injury, Cardiovascular Disease, Sickle Cell Disease, Impaired Vasodilation
• Experimental Therapeutic Treatment (D-4F) of Vascular Disease as it Relates to Heart disease and stroke

Research Interests

• Endothelial and cardiac cell biology, nitric oxide, molecular mechanisms of free radical generation, adenoviral gene transfer technology

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Ramani Ramchandran, PhD
Associate Professor
Pediatrics/Genetics

Phone: (414) 955-2387

Research Interests

•Axon guidance

•Hemangiomas of infancy

•Vascular biology

•Zebrafish

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Kevin Regner, MD, PhD
Assistant Professor
Medicine Nephrology

Phone: (414) 805-9050

Research Interests

• My laboratory is interested in studying the effects of ischemic acute kidney injury (AKI). We are collaborating with other KDC investigators on the following projects: 1) Evaluation of the protective effect of synthetic 20-HETE analogues in ischemic kidney injury. The long term goal of this research is to develop new therapies to prevent or treat AKI based on an understanding of the genetic, physiologic, and molecular mechanisms that underlie the effects of 20-HETE in ischemic kidney injury. 2) Evaluation of the long term effects of acute renal ischemia by utilizing genetic models of diabetes and hypertension that recapitulate the physiologic milieu in humans that increases susceptibility to AKI.

Matthias Riess, MD, PhD
Assistant Professor
Anesthesiology and Physiology

Phone: (414) 456-5745

Research Interests

• Dr. Riess’ research focuses on intracellular mechanisms of cardioprotection in general and preconditioning with volatile anesthetics in particular, especially the role of mitochondrial function as a trigger and effector of cardioprotection.

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Jeanne L. Seagard, PhD
Professor of Anesthesiology and Physiology
Director, Veterans Affairs Research Laboratory
Anesthesia Research 151
Zablocki Veterans Affairs Medical Center

Phone: (414) 384-2000 ext. 41589 

Research Interests

• Research from Dr. Seagard's laboratory focuses on determining the central mechanisms involved in the neural control of blood pressure and investigating the central integration of afferent nerve activity from barosensitive receptors.

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Andrey Sorokin, PhD
Associate Professor
Medicine/Nephrology

Phone: (414) 955-4438

Research Interests

• Understanding the Details of Signaling Pathways Leading from G-protein Coupled Receptors and Tyrosine Kinases through Adaptor Proteins to Downstream Signaling Molecules
• Investigation of the Cox-2-dependent Molecular Mechanisms of Resistance of Cells to Apoptosis

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Alexander Starushchenko, PhD
Assistant Professor
Department of Physiology

Phone: (414) 955-8475

Research Interests

• We are interested in the normal and pathophysiological regulation of epithelial ion channels. A particular emphasis is placed on the epithelial Na+ channel (ENaC). The long term control of blood pressure involves Na+ homeostasis through the precise regulation of ENaC in the aldosterone-sensitive distal nephron.

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David F. Stowe, MD, PhD
Professor
Anesthesiology/Clinical

Phone: (414) 456-5722

Research Interests

• Role of Mitochondrial Bioenergetics, NADH Levels and ATP Synthesis
• Mechanisms of Injury to the Heart when its Blood Supply is Interrupted
• Mechanisms of Preservation during Cold Storage as in Heart Transplantation
• Effects of Drugs and Preservation Agents to Protect the Heart Against Ischemic Damage

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Niloofar Tabatabai,  PhD
Assistant Professor
Medicine/Endocrine

Phone: (414) 955-8452

Research Interest

• I study the molecular expression and regulation of the kidney sodium-glucose cotransporters (SGLTs).

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Aoy Tomita-Mitchell, PhD
Assistant Professor
Surgery/Cardiothoracic Pediatrics

Phone: (414) 955-4531

Research Interests

• We are interested in identifying genetic risk factors for congenital heart disease. We believe the ability to identify these genetic risk factors will allow us to investigate the relationship between genetic deficits and molecular pathways and clinical variability, in order to make early and accurate diagnosis. The long-term goal for this research is to improve intervention strategies and long-term outcomes for our patients.

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Scott Van Why, MD
Associate Professor
Pediatrics (Nephrology)

Phone: (414) 337-7140

Research Interests

• Acute renal failure remains a major medical problem that contributes to high patient morbidity and associated mortality of greater than 50%. My laboratory is exploring the genetic basis for resistance or susceptibility to develop renal failure after ischemic injury to the kidney.

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David C. Warltier, MD, PhD
Chairman and Professor
Anesthesiology

Phone: (414) 805-8703

Research Interests

• Cardiovascular Physiology & Pharmacology with Special Emphasis on Angiogenesis in the Coronary Circulation and Pharmacological Cardioprotection Against Myocardial Infarction

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George A. Wilkinson, PhD
Assistant Professor - Pediatrics
Investigator - Children's Research Institute

Phone: (414) 955-2389

Research interests

•Angiogenesis, developmental biology, mouse genetics, signal transduction.

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