Cardiovascular Center

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Elizabeth Rogers Jacobs, MD
Professor and Associate Dean of Research, MCW,
Associate Chief of Staff, Research and Development, Zablocki, VA

Phone: (414) 384-2000 x41430

Research and Professional Experience

1977-1980 Internship and Residency, University of Kansas School of Medicine, Internal Medicine
1980-1982 Fellowship, Univ. of Arkansas Health Science Center, Pulmonary and Critical Care Medicine
1982-1984 Assistant Professor, University of Oklahoma Health Science Center, Medicine
1984-1987 Assistant Professor and Director of Research, Rush-Presbyterian-St. Luke’s Medical Center
1984-1989 Electrophysiologic Research and Training, Rush-Presbyterian-St. Luke’s Medical Center
1987-1989 Co-Director, Patch Clamp Center, Rush-Presbyterian-St. Luke’s Medical Center
1989 1999 Associate Professor of Medicine and Physiology, Medical College of Wisconsin
1999-present Professor of Medicine and Physiology
2000-present Associate Director, Cardiovascular Research Center, Medical College Wisconsin
2001-present Division Director, Pulmonary and Critical Care Medicine
2004-present Co-director Translational Research Center, Medical College of Wisconsin

Selected Awards And Other Professional Activities

Grant review committee for Chicago Heart Association (1985-1989)
Co-Chairman, Program Committee for Chicago Lung Association sponsored Markfield Conference, October, 1989; Chair 1998-present
Medical Student Honors Thesis Committee MCW member, 1994 to present
Chair, Faculty Development Committee, Department of Medicine, MCW, 1998-2002.
Member Rank and Tenure Committee Medical College of Wisconsin, 2002-present.
Ad hoc reviewer, SBIR and SBTIR scientific review group, March 2000, Feb 2001, October, 2003.
Member Research Committee, Northern Affiliate American Heart Association, 2000- present.
Consulting Editor, American Journal Physiology: Heart, 2000-2005
Member Research Committee, Wisconsin Lung Association, 2001-present.
Member Respiratory and Integrative Biology and Translational Research NIH Study section, 2004 to present.

Research Projects

  • Lipid Modulators of Pulmonary Vascular Tone.
    Studies role of cyp450s in mediating VEGF and NO induced changes in pulmonary vascular tone.
  • Mechanisms of High Flow Induced Vasculopathy.
  • The aims of this proposal are to examine the cellular and ionic mechanisms which underlie flow induced vasculopathy localized to the left lower lobe of the lung in juvenile pigs.
  • Molecular and Cellular Mechanisms Regulating Pressure-Dependent Autoregulation of Microvascular Blood Flow. 

 Selected Recent Publications

  •  Jacobs ER, Daling Zhu, Stephanie Gruenloh, Bernardo Lopez, Meetha Medhora. VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P450 hydroxylase. In press, American Journal of Physiology: Lung cellular and Molecular Physiology, 2006, 291:L36-L77.
  • Yuenmu Chen, Meetha Medhora, John R. Falck, Kirkwood A. Pritchard Jr., Elizabeth R. Jacobs. Mechanisms of activation of eNOS by 20-hydroxyeicosatetraenoic acid and VEGF in bovine pulmonary artery endothelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 2006, 291:L378-L385 .

  • Anuradha Dhanasekaran, Rula Al-Saghir, Bernardo Lopez, Ying Gao, David D Gutterman, Elizabeth R. Jacobs and Meetha Medhora: Protective Effects of Epoxyeicosatrienoic acids (EETs) on Human Endothelial Cells from the Pulmonary and Coronary Vasculature. American Journal of Physiology: Heart Circ. Physiol., 2006, 291:H517-H531.

  • Dunn LK, Gruenloh SK, Dunn BE, Reddy DS, Falck JR, Jacobs ER and Medhora M:Chick chorioallantoic membrane as an in vivo model to study vasoreactivity: characterization of development-dependent hyperemia induced by epoxyeicosatrienoic acids (EETs). Anatomical Records A Discov Mol Cell Evol Biol. 285(2):771-80, 2005.

  • Medhora M, Daniels J, Mundey K, Fisslthaler B, Busse R, Jacobs ER and Harder DR: Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells. American Journal of Physiology - Heart & Circ. Physiol. 2003, 284:H215-H224.

Publications as listed in PubMed

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