David X. Zhang, PhD
The overall emphasis of Dr. David X. Zhang's research is to understand the cellular mechanisms by which the endothelium regulates blood vessel tone in both normal physiological conditions and disease states, such as ischemic heart disease and hypertension.
Research Technician III
I function as the manager for Dr. David Zhang’s lab, ensuring their IRB and IACUC protocols are up to date and accurate, supervising grant spending and working in tandem with the other lab members to reach our research objectives. My science experience is in molecular biology, cell culture (human, bovine endothelial cells; rat neonatal myocytes) and animal models of ischemia/reperfusion lung injury.
Yoshinori Nishijima, PhD
My current research is focused on understanding the transient receptor potential vanilloid 4 (TRPV4) channel to Angiotensin II-induced impairment of vasodilation in animals and humans.
Natalya Zinkevich, PhD
Research Scientist I
My research interests are related to vascular health and disease. Specifically, I am interested in the role of endothelial cells in mediating vasodilation. Within this broad topic, I address three questions:
a) How do the mechanisms of endothelium-dependent dilation change during aging and with the onset of coronary artery disease?
b) What is the role of cellular enzymatic sources of reactive oxygen species in this process?
c) How does the transient receptor potential vanilloid 4 (TRPV4) channel superfamily contributes to vasorelaxation?