Cardiovascular Center

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The Benjamin Lab Members


Ivor Benjamin, MD, FAHA, FACC
Principal Investigator

ibenjamin@mcw.edu

Katie Mitzelfelt
Graduate Student

I have a broad interest in the area of stem cells and regenerative medicine. My project in the Benjamin Lab is modeling myofibrillar myopathy induced by a mutation in a small molecular weight heat shock protein, αB-crystallin, using differentiation of patient-specific iPSCs to both cardiomyocytes as well as multi-nucleated myotubes in culture.

kmitzelfelt@mcw.edu


Qiang Dai, PhD
Research Associate II

Our laboratory has longstanding interests in the role that stress response (HSF/HSP) pathways play in the development, progression, and, ultimately, the prevention of acquired and inheritable cardiac diseases.  My studies of genetically engineered mouse models and somatic cell cultures are exploring the mechanisms underlying the effects of genetic, metabolic (e.g., redox), and other perturbations in ischemic cardioprotection and
heart failure. 

 

qdai@mcw.edu

 


Shuping Lai, PhD
Research Associate II

My research project aims on modeling cardiac diseases in a culture dish by utilizing patient specimens. We are creating cardiomyocytes from human induced pluripotent stem cells, differentiate them into cardiomyocytes and use them as a means to mimic the disease in a dish. My major interests are drug-screenings and biochemical assays to exhibit different susceptibilities of cardiac cells to cardiac drugs, to predict adverse drug responses more accurately and to find best suitable drugs for cardiac diseases.

slai@mcw.edu

        

Michael Riedel, PhD
Research Scientist II

My current scientific research project focuses on human induced pluripotent stem cells and their differentiation into cardiomyocytes. I am responsible for the production and maintenance of human iPS cells that are generated from somatic cells and tissues of patients and their differentiation into cardiomyocytes. We are currently in the process of using these cardiomyocytes to develop a state-of-the-art approach to mimic atrial fibrillation and other diseases in a cell/tissue culture model. Our work will hopefully lead to a fuller understanding of how diseases affect the cells in the heart and how they progress over time.

mriedel@mcw.edu

 

Mohammed Aldakkak, MD
Research Scientist I

My ongoing research focuses on the role of mitochondria in cardiac injury during ischemia and reperfusion, with a special emphasis on ion homeostasis, proteins of the electron transport chain, and free radical generation using the ex-vivo heart and mitochondrial models. By joining the Benjamin lab, I aim to use my experience in mitochondrial bioenergetics as a foundation to further expand my understanding of the complex regulation of cellular redox balance using, among other tools, redox-sensitive dyes in new models such as transgenic mice and patient-derived stem cells. This will hopefully help to develop new strategies for targeting specific organelles that are involved in cardiovascular dysfunction

maldakka@mcw.edu

 

 

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