Cardiovascular Center & Associated Laboratories
Research Areas of Focus:
1) Stroke (cerebrovascular disease)
2) Heart Attack (ischemic heart disease)
3) Tumor Control (tumor angiogenesis)
4) Heart Failure (congestive heart failure)
5) High Blood Pressure (hypertension)
6) Prevention (which supports non-surgical treatments for cardiovascular disease)
Faculty Name - Research Interests - Focus Areas
John A. Auchampach, PhD
Associate Professor
Pharmacology & Toxicology
jauchamp@mcw.edu
456-5643 • Molecular Cardiovascular Pharmacology 1) Heart Attack
Ellis Avner, MD
Professor
Medicine/Pediatric Nephrology
Director, Children’s Research Institute
eavner@mail.mcw.edu
456-5744 • Basic Cellular and Molecular Pathophysiology of Polycystic Kidney Disease and it’s Complications, which include Hypertension, Heart Failure, and Stroke • Goal is to identify the Basic Cellular Abnormalities of the Polycystic Endothelial and Epithelial Cell, and Target such Abnormalities with Specific Pharmacological Inhibitors, with the Ultimate Goal of Preventing Disease Progression and the Development of Complications 1) High Blood Pressure 2) Heart Failure 3) Stroke 4) Prevention
Zeljko J. Bosnjak, PhD
Professor
Anesthesiology
zbosnjak@mcw.edu
456-5687 • Cellular Mechanisms of Anesthetic Action/Cellular Signal Transduction Pathways Responsible for Anesthetic-Induced Cardioprotection and the Modulation of ATP Sensitive Potassium Current in Cardiac Myocytes by Ischemia and Volatile Anesthetics / Genetic Basis for Differences in Anesthetic Response and Neuropathy and Calcium Signaling 1) Heart Attack
Owen W. Griffith, PhD
Professor
Biochemistry
griffith@mcw.edu
456-8778 • Pharmacological Regulation of Nitric Oxide Synthases • Dr. Griffith is also a Founder and Board Member of ArgiNOx Pharmaceuticals, Inc., a New Biopharmaceutical Company currently Carrying Out a Phase 2 Clinical Trial of ANO-1020, for Treatment of Cardiogenic Shock Following Acute Myocardial Infarction 1) Heart Attack 2) Heart Failure
David D. Gutterman, MD
Senior Associate Dean Research
Vice Chairman, Cardiovascular Medicine
dgutt@mcw.edu
456-8495 • Vascular Biology with a Focus on Human Coronary Vascular Function • Effect of Disease on Arteriolar Dilation Ability Integrating the Role of Oxygen Radicals & Other Reactive Species in Modulating Dilation Both at the Endothelial & Smooth Muscle Levels • Major Interest in the Mechanisms of Dilation Especially as They Relate to Endothelial Derived Hyperpolarization Factors 1) Heart Attack
David R. Harder, PhD
Professor
Physiology
Director, CVC
dharder@mcw.edu
456-5611 • Cellular Mechanisms Controlling Cerebral Blood Flow • Endothelial Dependent Mechanisms in Vascular Smooth Muscle • Tumor Angiogenesis in the Brain 1) Stroke 2) Tumor Control 3) High Blood Pressure 4) Prevention
Anne Hoch, DO
Associate Professor
Orthopaedic Surgery Rehabilitation
azeni@mcw.edu
805-7461 • Consequences of Athletic Amenorrhea in High School and College Girls • Prevalence of Disordered Eating, Amenorrhea, Osteoporosis and Early Cardiovascular Disease among High School Girls – “Female Athlete Tetrad” 1) Heart Attack 2) Prevention
Quinn H. Hogan, MD
Professor
Anesthesiology
qhogan@mcw.edu
456-5727 • Cerebral Blood Flow Regulation, Microcirculation, Oxygen Transport, Functional Hyperemia, and Effect of Anesthetic Agents • Causes of Pain 1) Stroke
Anthony G. Hudetz, PhD
Professor
Anesthesiology
ahudetz@mcw.edu
456-5622
• Cerebral Blood Flow Regulation, Microcirculation, Oxygen Transport, Functional Hyperemia, and Effect of Anesthetic Agents 1) Stroke
Elizabeth R. Jacobs, MD
Professor and Chief
Pulmonary and Critical Care Medicine
ejacobs@mail.mcw.edu
456-7040 • Longstanding (~15 Year) Interest in Endogenous Factors which Control Pulmonary Vascular Tone • Correlation of Expression and Functional Role of Cytochrome P450 Metabolites in Pulmonary Arteries, and Investigations of Signaling Mechanisms through which these Products Change the Tension of Pulmonary Arteries • Developed a Porcine Model of Surgical Anastomosis of the Left Lower Lobe Pulmonary Artery to the Aorta to Create a Localized High Flow Pressure State • Role of Cytochrome P450 metabolites in promoting pulmonary angiogenesis. 1) Heart Failure 2) High Blood Pressure
Girija Ganesh Konduri, MD
Associate Professor
Pediatrics
Chief of Neonatology
gkonduri@mcw.edu
266-6452 • Mechanisms of Transition in Fetal Pulmonary Circulation and Persistent Pulmonary Hypertension (PPH) 1) High Blood Pressure
Ellen T. McCarthy, MD
Assistant Professor
Medicine/Nephrology
emccarth@mail.mcw.edu
456-6730 • Proteinuria, an early Indicator and of Chronic Cardiovascular Diseases such as Diabetes, Hypertension and Heart Failure • Mechanisms and Pathophysiology of Proteinuria and in its Treatment
• Mechanisms Underlying the Pathophysiology of Glomerular Capillary and Renal Vasculature during Chronic Cardiovascular Diseases and in Renal Transplant Patients 1) Prevention 2) High Blood Pressure
Meetha M. Medhora, PhD
Associate Professor
Medicine/Pulmonary
medhoram@mcw.edu
456-5612 • Lipid-Mediated Signaling in Angiogenesis • Study of Human Endothelial Cell Morphogenesis using Recombinant Adenoviral Vectors for Gene Transfer • Pulmonary Vasoregulatory Mechanisms 1) Prevention 2) Heart Attack
Hiroto Miura, PhD
Assistant Professor
Medicine/Cardiovascular
hmiura@mcw.edu
456-5639 • Intermediate Conductance Calcium-Activated Potassium Channels in Cardiovascular Disease Endothelium-Derived Hyperpolarizing Factors (EDHF) • Sarcolemmal and Mitochondrial ATP-Sensitive Potassium Channels in the Coronary Microcirculation 1) Prevention 2) Heart Attack
Paula North, MD
Professor and Chief
Pathology
pnorth@mcw.edu 266-6288 • Cell/molecular biology of vascular anomalies (developmental/acquired)
Keith T. Oldham, MD
Professor and Chief
Pediatric Surgery
koldham@mcw.edu
266-6550 • Acute Lung Injury, Shock, Sepsis, Pulmonary Injury, Cardiovascular Disease, Sickle Cell Disease, Impaired Vasodilation • Experimental Therapeutic Treatment (D-4F) of Vascular Disease as it Relates to Heart disease and stroke 1) Heart Attack 2) Prevention 3) Stroke 4) Tumor Control
Galen M. Pieper, PhD
Professor
Transplant Surgery
gpieper@mail.mcw.edu
456-6929 • Role of Nitric Oxide (NO) Derived from Inducible NO synthase (iNOS) in Acute Cardiac Transplant Rejection • Development of Strategies to Measure and Quantitate Free-Radical Production during Alloimmune Activation and Rejection 1) Heart Failure 2) Prevention
Kirkwood A. Pritchard, PhD
Professor and Vice Chair, Research
Pediatric Surgery
kpritch@mcw.edu
456-5615 • Acute Lung Injury, Shock, Sepsis, Pulmonary Injury, Cardiovascular Disease, Sickle Cell Disease, Impaired Vasodilation • Experimental Therapeutic Treatment (D-4F) of Vascular Disease as it Relates to Heart disease and stroke 1) Heart Attack 2) Prevention 3) Stroke 4) Tumor Control
Tara L. Sander, PhD
Assistant Professor
Pediatric Surgery
sandert@mcw.edu
456-5807 • Cardiac Valve Formation and Function Mediators of Congenital Heart Disease
• Transcriptional Mechanisms that Control Endothelial Cell Signaling and Proliferation 1) Heart Failure
Virginia J. Savin, MD
Professor
Medicine/Nephrology
vsavin@mcw.edu
456-6730 • Proteinuria, a known Risk for Cardiovascular Disease • Mechanisms operative in Pathophysiology of Proteinuria and in its Treatment 1) Heart Attack 2) High Blood Pressure
Andrey Sorokin, PhD
Associate Professor
Medicine/Nephrology
sorokin@mcw.edu
456-4438 • Understanding the Details of Signaling Pathways Leading from G-protein Coupled Receptors and Tyrosine Kinases through Adaptor Proteins to Downstream Signaling Molecules
• Investigation of the Cox-2-dependent Molecular Mechanisms of Resistance of Cells to Apoptosis 1) Tumor Control 2) Prevention 3) High Blood Pressure
David F. Stowe, MD, PhD
Professor
Anesthesiology/Clinical
dfstowe@mcw.edu 456-5722
• Role of Mitochondrial Bioenergetics, NADH Levels and ATP Synthesis • Mechanisms of Injury to the Heart when its Blood Supply is Interrupted • Mechanisms of Preservation during Cold Storage as in Heart Transplantation • Effects of Drugs and Preservation Agents to Protect the Heart Against Ischemic Damage 1) Heart Attack 2) Heart Failure
David C. Warltier, MD, PhD
Chairman and Professor
Anesthesiology
dwarltier@mcw.edu
805-8703 • Cardiovascular Physiology & Pharmacology with Special Emphasis on Angiogenesis in
the Coronary Circulation and Pharmacological Cardioprotection Against Myocardial Infarction
1) Heart Attack 2) Heart Failure 3) Prevention
Carol Williams, PhD
Associate Professor
Pharmacology & Toxicology
cwilliam@mailmcw.edu
456-5640 1) Heart Attack 2) Heart Failure 3) Prevention
Xuefeng "David" Zhang, PhD
Assistant Professor
Medicine/Cardiovascular
456-5633 • Diabetes and Potassium Channel Function • Free-radical and Potassium Channel Activity • Mechanisms of Flow Mediated in Coronary Microcirculation 1) Prevention
Free Radical Research Center
Directed by:
Balaraman Kalyanaraman, PhD
Chair and Professor, Biophysics • Promotes and Stimulates Free Radical Research at MCW and Helps Researchers Engaged in Free Radical Research acquire NIH and other Extramural Funding
• Unique Because it is Closely Associated with an EPR Research Resource (only physical technique that can detect unambiguously free radicals in biological systems) and an MRI Facility • Promotes Translational Research in Free Radical-mediated Diseases at MCW and Neighboring Institutes and Develops Therapeutic Interventions in Free Radical Based Disease Processes • Improves the Understanding of the Mechanism of Action of Antioxidants (i.e., agents that scavenge or inhibit free radical formation) in Human Disease
Core Laboratories • Adenoviral Core, Directed by Meetha Medhora, PhD • Histology Core, Directed by Paula North, MD, PhD