Research:

Dr. Sorokin's research is focused on mechanisms of initiation and progression of proliferative glomerulonephritis.  He is interested in the role of protein-protein interactions in endothelin-induced intracellular signaling pathways responsible for vasoconstrictor, hypertrophic and mitogenic actions of endothelins in kidney cells as well as the role of apoptosis in kidney diseases.  He examines the hypothesis that cyclooxygenase 2, which generate prostaglandins from arachidonic acid, protects GMC from apoptosis via up-regulation of genes, inhibit activation of pro-apoptotic Bcl-2 family proteins, control activity of nitric oxide synthases and regulate efflux of xenobiotics.