Ronald N. Hines, PhD - Publications
DOCTORAL DISSERTATION:
Hines, R.N. The interaction of 1,1-disubstituted hydrazines with drug metabolizing enzymes; Presented to the Faculty of Biochemistry, University of Texas Southwestern Medical School, Dallas, Texas, August 1980.
ORIGINAL PAPERS:
1. Hines, R.N. and Wenner, C.E. The role of Pi in glycolytic inhibition of calcium ion uptake in ELD ascites tumor cells. Biochim. Biophys. Acta. 465:391-399, 1977.
2. Hines, R.N. and Prough, R.A. The characterization of an inhibitory complex formed with cytochrome P-450 and a metabolite of 1,1-disubstituted hydrazines. J. Pharmacol. Exp. Ther. 214:80-86, 1980.
3. Prough, R.A., Freeman, P. and Hines, R.N. The N-oxidation of hydrazine derivatives by the purified liver microsomal FAD-containing monooxygenase. J. Biol. Chem. 256:4178-4184, 1981.
4. Bresnick, E., Levy, J., Hines, R.N., Levin, W. and Thomas, P. The molecular cloning of cytochrome P450c information. Arch. Biochem. Biophys. 212:501-507, 1981.
5. Wiebkin, P., Sieg, M.S., Nelson, R.E., Hines, R.N. and Prough, R.A. Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (Line P815). Biochem. Pharmacol. 31:2921-2928, 1982.
6. Omiecinski, C.J., Bresnick, E., Hines, R.N., Foldes, R.L. and Levy, J.B. Molecular induction by phenobarbital of a rat hepatic form of cytochrome P450: Expression of a four kilobase messenger RNA. Arch. Biochem. Biophys. 227:478-493, 1983.
7. Raha, C., Hines, R.N. and Bresnick, E. Demonstration of microsomal oxygenation of the benzo ring of 6-nitrobenzo(a)pyrene by thin layer chromatography. J. Chromatog. 229:231-239, 1984.
8. Hines, R.N., Levy, J.B., Conrad, R.D., Iversen, P.L., Shen, M.L. Renli, A.M. and Bresnick, E. Gene Structure and nucleotide sequence for rat cytochrome P450c. Arch. Biochem. Biophys. 237:465-476, 1985.
9. Foldes, R.L., Hines, R.N., Ho, K.L., Shen, M.L., Nagel, K.B. and Bresnick, E. 3-Methylcholanthrene-induced expression of a cytochrome P450 gene. Arch. Biochem. Biophys. 239:137-146, 1985.
10. Houser, W.H., Hines, R.N. and Bresnick, E. Implication of the 4S polycyclic aromatic hydrocarbon binding protein in the transregulation of rat cytochrome P450c expression. Biochemistry 24:7839-7845, 1985.
11. Mathis, J.M., Prough, R.A., Hines, R.N., Bresnick, E. and Simpson, E.R. Regulation of cytochrome P450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Arch. Biochem. Biophys. 246:439-448, 1986.
12. Koser, P.L., Faletto, M.B., Bansal, S.K., Caballes, L., Bresnick, E., Hines, R.N. and Gurtoo, H.L. Aflatoxin B1-4-hydroxylase is associated with cytochrome P3-450 in C57BL/6 mouse liver. Biochem. Biophys. Res. Commun. 142:872-878, 1987.
13. Iversen, P.L., Heiger, W.J., Bresnick, E. and Hines, R.N. Structural details of the human cytochrome P-450c gene. Arch. Biochem. Biophys. 256:397-401, 1987.
14. Iversen, P.L., Mata, J.E. and Hines, R.N. Rapid isolation of RNA and DNA from cultured cells or whole tissues with a benchtop ultracentrifuge. BioTechniques 6:521-524, 1987.
15. Houser, W.H., Cunningham, C.K., Hines, R.N., Schaeffer, W.I. and Bresnick, E. Interaction of the 4S polycyclic aromatic hydrocarbon binding protein with the cytochrome P450c gene. Arch. Biochem. Biophys. 259:215-223, 1987.
16. Pasanen, M., Stacey, S., Lykkesfeldt, A., Briand, P., Hines, R.N. and Autrup, H. Induction of cytochrome P450IA1 gene expression in human breast tumour cell lines. Chem. Biol. Interact. 66:223-232, 1988.
17. Hines, R.N., Mathis, J.M. and Jacob, C. Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 9:1509-1605, 1988.
18. Tiesman, J., Meyer, A., Hines, R.N., and Rizzino, A. Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells. In Vitro Cell. Develop. 24:1209-1216, 1988.
19. Mathis, J.M., Houser, W.H., Bresnick, E., Cidlowski, J.A., Hines, R.N., Prough, R.A. and Simpson, E.R. Glucocorticoid regulation of the rat cytochrome P-450c (P450IA1) gene: Receptor binding within intron I. Arch. Biochem. Biophys. 269:93-105, 1989.
20. McLemore, T.L., Adelberg, S., Czerwinski, M., Hubbard, W.C., Yu, S.J., Wood, T., Hines, R.N. and Boyd, M.R. Altered regulation of the Cytochrome P450IA1 gene: Novel inducer-independent gene expression in pulmonary carcinoma cell lines. J. Natl. Cancer Inst. 81:1787-1794, 1989.
21. McLemore, T.L., Adelberg, S., Liu, M.C., McMann, N.A., Yu, S.J., Hubbard, W.C., Czerwinski, M., Wood, T.G., Storeng, R., Lubet, R.A., Eggleston, J.C., Boyd, M.R., and Hines, R.N. CYP1A1 expression in lung cancer patients: Evidence for cigarette smoke-induced expression in normal lung and altered gene regulation in primary pulmonary carcinomas. J. Natl. Cancer Inst. 82:1333-1339, 1990.
22. Pasannen, M., Haaparanta, T., Sundin, M., Sivonen, P., Vahakangas, K., Raunio, H., Hines, R., Gustafsson, J.A. and Pelkonen, O. Immunochemical and molecular biological studies on human placental cigarette smoke-inducible cytochrome P450-dependent monooxygenase activities. Toxicology 62:175-187, 1990.
23. Thomsen, J.S., Nissen, L., Stacey, S.N., Hines, R.N. and Autrup, H. Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors. Eur. J. Biochem. 197:577-581, 1991.
24. Hines, R.N., O'Connor, K.C., Vella, G. and Warren, W. Large scale purification of plasmid DNA by anion-exchange high performance liquid chromatography. BioTechniques 12:430-434, 1992.
25. Boucher, P.D. Ruch, R.J. and Hines, R.N. Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. J. Biol. Chem. 268:17384-17391, 1993.
26. States, J.C., Quan, T., Hines, R.N., Novak, R.F., and Runge-Morris, M. Expression of human cytochrome P4501A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. Carcinogenesis 14:1643-1649, 1993.
27. Piechocki, M.P. and Hines, R.N. Oligonucleotide design and optimized protocol for site-directed mutagenesis. BioTechniques 16:702-707, 1994.
28. Thomsen, J.S., Wang, X., Hines, R.N. and Safe, S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis 15:933-938, 1994.
29. Shehin-Johnson, S.E., Williams, D.E. Larsen-Su, S., Stresser, D. and Hines, R.N. Tissue-specific expression of flavin-containing monooxygenase (FMO) forms 1 and 2 in the rabbit. J. Pharmacol. Expt'l. Ther. 272:1293-1299, 1995.
30. Peters, L.D., Livingstone, D.R., Shehin, S., Hines, R.N., and Schlenk, D. Characterization of hepatic flavin monooxygenase from the turbot (Scophthalmus maximus L.). Xenobiotica 25:121-131, 1995.
31. Boucher, P.D. and Hines, R.N. In vitro binding and functional studies comparing the human CYP1A1 negative regulatory element with orthologous sequences from the rodent genes. Carcinogenesis 16:383-392, 1995.
32. Lee, M.-Y., Smiley, S., Kadkhodayan, S., Hines, R.N., and Williams, D.E. Developmental regulation of flavin-containing monooxygenase (FMO) isoforms 1 and 2 in pregnant rabbit. Chem. Biol. Interact. 96:75-85, 1995.
33. Schlenk,D., Peters,L., Shehin-Johnson,S., Hines,R.N. and Livingstone,D.R. Differential expression and activity of flavin-containing monooxygenases in euryhaline and stenohaline flatfishes indicates potential osmoregulatory role. Comp. Biochem. Physiol. [C], 112C: 179-186, 1995.
34. Shehin-Johnson, S.E., Palmer, K. and Hines, R.N. Identification of tissue-specific DNaseI hypersensitive sites on the rabbit flavin-containing monooxygenase form 2 gene. Drug Metab. Disp. 24:891-898, 1996.
35. Luo, Z. and Hines, R.N. Identification of multiple promoters on the rabbit flavin-containing monooxygenase form 1 (FMO1) gene and observation of tissue-specific DNaseI hypersensitive sites. Arch. Biochem. Biophys. 336:251-160, 1996.
36. Rasheed, A., Hines, R.N. and McCarver-May, D.G. Variation in induction of human placental CYP2E1: Possible role in susceptibility to fetal alcohol syndrome. Toxicol. Appl. Pharmacol. 144:396-400, 1997.
37. McCarver, D.G., Byun, R., Hines, R.N., Hichme, M., Wegenek, W. A genetic polymorphism in the regulatory sequences of human CYP2E1: Association with increased chlorzoxazone hydroxylation in the presence of obesity and ethanol intake. Toxicol. Appl. Pharmacol. 152:276-281, 1998.
38. Larsen-Su, S., Krueger, S.K., Yueh, M.-F., Lee, M.-Y., Shehin, S.E., Hines, R.N. and Williams, D.E. Flavin-containing monooxygenase isoform 2: Developmental expression in fetal and neonatal rabbit lung. J. Biochem. Mol. Toxicol. 13:187-193, 1999.
39. Linder, M.W., Falkner, K.C., Srinivasan, G., Hines, R.N., and Prough, R.A. Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the aryl hydrocarbon receptor. Drug Metab. Revs. 31:247-271, 1999.
40. Liu, L., Fan, Q.I., El-Zaru, M.R., Vanderpool, K., Hines, R.N. and Marsh, J.D. Regulation of DHP receptor expression by elements in the 5' flanking sequence. Am. J. Physiol. 278: H1153-H1162, 2000.
41. Liu, L., O'Hara, D.S., Poornima, I., Cala, S.E., Hines, R.N. and Marsh, J.D. Developmental regulation of dihydropyridine receptor expression in heart. Mol. Cell. Biochem. 205:101-109, 2000.
42. Ledirac, N., Delescluse, C., Lesca, P., Piechocki, M.P., Hines, R.N., de Sousa, G., Pralavorio, M., and Rahmani, R. Diflubenzuron, a benzoyl urea insecticide, is a potent inhibitor of TCDD-induced CYP1A1 expression in HepG2 cells. Toxicol. Appl. Pharmacol. 164:273-279, 2000.
43. Hines, R.N., Cresteil, T., Luo, Z., McNally, K., Ding, X., Prough, R.A., Fitzpatrick, J.L., Ripp, S.L., Falkner, K.C., Ge, N.-L., Levine, A., and Elferink, C.J. Molecular regulation of genes encoding xenobiotic metabolizing enzymes: Mechanisms involving endogenous factors. Drug Metab. Disp., submitted.
CHAPTERS AND REVIEWS
1. Hines, R.N. and Prough, R.A. Evidence for inhibitory complexes formed with cytochrome P450 and a metabolite of 1,1-disubstituted hydrazines, in: Microsomes, Drug Oxidations and Chemical Carcinogenesis (Coon, M.J., Conney, A.H., Estabrook, R.W., Gelboin, H.V., Gillette, J.R. and O'Brien, P.J., eds.) Vol. II, pp 1215-1218, Academic Press, New York, NY, 1979.
2. Prough, R.A., Capdevila, J., Hines, R.N., Wiebkin, P. and McKillop, D. Analysis of the further metabolites of several carcinogenic and toxic compounds, in: Chromatographic Science Series, Biological/Biomedical Applications of Liquid Chromatography (Hawk, G.L., ed.) Vol. 18, pp 95-109, Marcel Dekker, Inc., New York, NY, 1980.
3. Wiebkin, P., Hines, R.N., Nelson, R.E. and Prough, R.A. Inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (Line P815), in: Advances in Experimental Medicine and Biology: Biological Reactive Intermediates II/Chemical Mechanisms and Biological Effects (Snyder, R., Parke, D.V., Kocsis, J.J., Jellow, D.J., Gibson, C.G. and Witmer, C.M., eds.) Vol. 136, part B, pp 1067-1075, Plenum Press, New York, NY, 1980.
4. Hines, R.N., Bresnick, E., Omiecinski, C. and Levy, J. Molecular Biology of Cytochrome P450, in: Extrahepatic Drug Metabolism and Chemical Carcinogenesis (Rydstrom, J., Montelius, J. and Bengtsson, M., eds.) pp 419-422, Elsevier Science Publishers, B.V., Amsterdam, 1983.
5. Hines, R.N., Foldes, R.L., Levy, J.B., Omiecinski, C.J., Ho, K?L., Shen, M?L. and Bresnick, E. Regulation of cytochrome P450 expression, in: Banbury Report #16: Genetic Variability in Responses to Chemical Exposure (Omenn, G. and Gelboin, H.V., eds.) pp. 37?49, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1984.
6. Bresnick, E., Foldes, R.L. and Hines, R.N. Induction of cytochrome P450 by xenobiotics. Pharmacol. Revs. 36:43S-51S, 1984.
7. Iversen, P.L., Hines, R.N. and Bresnick, E. The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P450; The past is prologue. BioEssays 4:15-19, 1986.
8. Autrup, H., Thomsen, J.S., Stacey, S. and Hines, R.N. Induction of cytochrome P450IA1 in human breast cancer cell lines, in: Cytochrome P-450-Biochemistry and Biophysics (Schuster, I., ed.) pp. ,Taylor and Francis, London, United Kingdom, 1989.
9. Pasanen, M., Stenback, F., Taskinen, T., Raunio, H., Sivonen, P., Hines, R., and Pelkonen, O. Human placental 7-ethoxyresorufin O-deethylase activity: Inhibition studies and immunological and molecular biological detection of P450IA1, in: Cytochrome P450 Biochemistry and Biophysics (Schuster, I., ed.) pp. 532-535, Taylor and Francis, London, United Kingdom, 1989.
10. Rizzino, A., Tiesman, J., Hines, R. and Kelly, D. Developmental regulation of the KS-FGF oncogene by embryonal carcinoma cells and early mouse embryos, in: Early Embryo Development and Paracrine Relationships (Heyner, S. and Wiley, L, eds.) pp. 53-66, Alan R. Liss, Inc., New York, 1990.
11. Hines, R.N., Piechocki, M.P. and Boucher, P.D. Molecular Mechanisms Controlling CYP1A Gene Expression, in: Frontiers in Biotransformation (Ruckpaul, K. and Rein, H., eds.) Vol. 9, pp. 85-110, 1994.
12. Hines, R.N., Cashman, J.R., Philpot, R.M., Williams, D.E. and Ziegler, D.M. The mammalian flavin-containing monooxygenases: Molecular characterization and regulation of expression. Toxicol. Appl. Pharmacol. 125:1-6, 1994.
13. Lawton, M., Cashman, J., Cresteil, T., Dolphin, C., Elfarra, A., Hines, R.N., Hodgson, E., Kimura, T., Ozols, J., Phillips, I., Philpot, R., Poulsen, L., Rettie, A., Williams, D. and Ziegler, D. A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Arch. Biochem. Biophys. 308:254-257, 1994.
14. Hines, R.N., Ansari, S.A. and Smolinski, S.M. Reporter genes to study regulatory mechanisms, in: Molecular Biology of the Toxic Response (Puga, A. and Wallace, K.B. , eds.) pp. 205-216, Taylor and Francis, Washington, D.C., 1998.
PATENTS:
1. States, J.C., Hines, R.N. and Novak, R.F. A Human Cell Culture System for Evaluating Cytotoxicity and Genotoxicity of Chemical Which May require Metabolic Activation, Patent No. 5,180,666, Issued 01/19/93.
ABSTRACTS
1. Resch, R., Hines, R.N., Hackney, J. and Wenner, C.E. Calcium interactions in intact ELD ascites tumor cells. Biophys.J. 6:111a, 1976.
2. Hines, R.N., Resch, R. and Wenner, C.E. The influence of inorganic phosphate on calcium uptake by ELD ascites tumor cells. Proc. 67th Annual Meeting Am. Assoc. Cancer Res. 17: 210, 1976.
3. Hines, R.N. and Prough, R.A. Characterization of a spectral complex formed with cytochrome P450 and a metabolite of 1,1 disubstituted hydrazines. Federation Proceedings 38:2272, 1979.
4. Prough, R.A. and Hines, R.N. The N oxidation of hydrazine derivatives by the purified microsomal mixed function amine oxidase. Fourth International Symposium on Microsomes and Drug Oxidations P238, 1979.
5. Hines, R.N. and Prough, R.A. Microsomal metabolism of 1,1-disubstituted hydrazines characterization of a spectral complex with cytochrome P450. XIth International Congress of Biochemistry R86, 1979.
6. Hines, R.N. and Prough, R.A. Evidence for a spectral complex formed with cytochrome P450 and a metabolite of 1,1-disubstituted hydrazines. Fourth International Symposium on Microsomes and Drug Oxidations, 1979.
7. Wiebkin, P., Hines, R.N. Nelson, R.E. and Prough, R.A. The inhibition of metabolism-mediated cytotoxicity by 1,1-disubstituted hydrazines in P815 mouse mastocytoma cells. Second International Symposium on Biological Reactive Intermediates: Chemical Mechanisms and Biological Effects, 1980.
8. Prough, R.A., Hines, R.N., Coomes, M.W., Cummings, S.W., Moloney, S.J. and Wiebkin, P.W. Multiple models of hydrazines as toxic agents. Federation Proceedings 40:3437, 1981.
9. Hines, R.N., Levy, J and Bresnick, E. Characterization of a genetic clone containing information for cytochrome P-450c. Federation Proceedings 41:2425, 1982.
10. Hines, R.N., Bresnick, E., Omiecinski, C.J., Levy, J., Levin, W. and Thomas, P. Molecular Biology of Cytochrome P-450. First International Symposium on Extrahepatic Carcinogenesis and Drug Metabolism, 1983.
11. Foldes, R.L., Hines, R.N., Levy, J.B. and Bresnick, E. Nuclear regulatory mechanisms involved in 3-methylcholanthrene (3-MC) inducible cytochrome P450 expression. Proceedings 75th Annual Meeting Amer. Assoc. Cancer Res. 25:40, 1984.
12. Hines, R.N., Houser, W.H., Iversen, P.L., Foldes, R., Heiger, W., Conrad, R.D. and Bresnick, E. Regulation of Expression of Rat and Human Cytochrome P450c. UCLA Symposium on Biochemical and Molecular Epidemiology of Cancer, 1985.
13. Iversen, P.L., Heiger, W.J., Bresnick, E. and Hines, R.N. Isolation and fine structure of the human cytochrome P450c gene. Federation Proceedings 44:6061, 1985.
14. Hines, R.N., Heiger, W.J., Foldes, R.L., Iversen, P.L., Conrad, R.D. and Bresnick, E. Regulation of Cytochrome P450c Expression in Rat and Human. Proceedings 76th Annual Meeting Amer. Assoc. Cancer Res. 26:17, 1985.
15. Houser, W.H., Hines, R.N. and Bresnick, E. Interaction of the 4S polycyclic aromatic hydrocarbon (PAH) binding protein with rat liver DNA. Proceedings 76th Annual Meeting Amer. Assoc. Cancer Res. 26:20, 1985.
16. Wilson, W.C., White, H., Hines, R.N. and Bresnick, E. Molecular cloning of microsomal epoxide hydrolase (EH) and acetylaminofluorene induction of mRNAEH. Federation Proceedings 45:2826, 1986.
17. Hines, R., Iversen, P., Bresnick, E. and Heiger, W. Studies on the structure and expression of human cytochrome P450c. Federation Proceedings 46:1254, 1987.
18. Hines, R.N., Heidrick, M., Mata, J. and Yu, Y., Tissue specific expression of rat cytochrome P450 II E1. Advances in the Biology and Chemistry of N-Nitroso and Related Compounds, 1988.
19. McLemore, T., Adelberg, S., Letterst, C., Coudert, B., Hubbard, W., Czerwinski, M., Wood, T. Hines, R., Liu, M., Eggleston, J. and Boyd, M. Relationship between 4-ipomeanol metabolism and P450IA1 gene expression in human lung and pulmonary carcinoma tissue. American Federation for Clinical Research, 1988.
20. McLemore, T., Adelberg, S., Coudert, B., Liu, M., Hubbard, W., Czerwinski, M., Wood, T., Hines, R., Eggleston, J. and Boyd, M. P450IA1 gene expression in normal lung and tumor tissue from lung cancer patients. American Federation for Clinical Research, 1988.
21. McLemore, T., Coudert, B., Adelberg, S., Czerwinski, M., Hines, R., Plopper, C., Wood, T., Boyd, M. 4-Ipomeanol metabolism and P450IA1 gene expression in human lung cancer cell lines. Proceedings 79th Annual Meeting Amer.Assoc. Cancer Res., 1988.
22. Hines, R.N. and Jacob, C. Identification of cis-regulatory elements on the human cytochrome P450IA1 gene. Proceedings 79th Annual Meeting Amer. Assoc. Cancer Res., 1988.
23. Autrup, H., Thomsen, J., Hines, R. and Stacey, S. Induction of cytochrome P450IA1 in human breast cancer cell lines. Eur.J.Cancer Clin.Oncol., 1989.
24. Hines, R.N., Minehart, E., Pasanen, M. and Autrup, H. Regulation of human cytochrome P450IA1 gene expression. Proceedings 80th Annual Meeting Amer. Assoc. Cancer Res. 30:37, 1989.
25. McLemore, T., Storeng, R., Adelberg, S., Czerwinski, M., Yu, S., Nhamburo, P., Gonzalez, F., Hines, R. and Boyd, M. Expression of different cytochrome P450 genes in human lung cancer cell lines. Proceedings 80th Annual Meeting Amer. Assoc. Cancer Res. 30:41, 1989.
26. Autrup, H. Thomas, J.S., Nissen, L. and Hines, R.N. Regulation of cytochrome P450IA1 in human breast cancer cells. Proceedings 81st Annual Meeting Amer. Assoc. Cancer Res. 31:162, 1990.
27. McLemore, T., Adelberg, S., Lin, W., Yu, S., Czerwinski, M., Hines, R. and Gonzalez, F. Altered regulation of different cytochrome P450 genes in pulmonary carcinomas. Clinical Res. 38:311A, 1990.
28. Hines, R.N., Liu, M., Adelberg, S. and McLemore, T. Regulation of human CYP1A1 expression. Proceedings of the VIIIth International Symposium on Microsomes and Drug Oxidations p. 67, 1990.
29. Nissen, L., Thomsen, J.S., Hines, R.N. and Autrup, H. Regulation of the CYP1A1 gene in human breast carcinoma cell lines. Proceedings of the VIIIth International Symposium on Microsomes and Drug Oxidations p. 85, 1990.
30. Hines, R.N. and Ruch, R.J. Characterization of the negative regulatory element of human CYP1A1. The Toxicologist 11:642, 1991.
31. Lee, M.Y., Stresser, D.M., Hines, R.N. and Williams, D.E. Induction of flavin-containing monooxygenase (FMO) in rabbit lung during gestation. The Toxicologist 11:866, 1991.
32. Hines, R.N. and Ruch, R.J. Human CYP1A1 negative regulation by an upstream silencer element. FASEB J. 5:A1164, 1991.
33. Ruch, R.J. and Hines, R.N. Regulation of human CYP1A1 by an upstream silencer element. Proceedings of the 82nd Annual Meeting Amer. Assoc. Cancer Res. 32:294, 1991.
34. Williams, D.E., Lee, M.-Y., and Hines, R.N. Developmental regulation of pulmonary flavin-containing monooxygenase (FMO) during gestation in pregnant rabbits and in fetal and neonatal rabbits. Proceedings of the 15th International Congress of Biochemistry, 1991.
35. Boucher, P.D., Ruch, R.J. and Hines, R.N. Characterization of the human CYP1A1 negative regulatory element. The Toxicologist 12:913, 1992.
36. Williams, D.E., Lee, M.-Y., Hines, R.N. and Stresser, D.M. Developmental regulation of flavin-containing monooxygenase (FMO) in lung of fetal and neonatal rabbits. The Toxicologist 12:1270, 1992.
37. Ruch, R.J., Boucher, P.D., Hines, R.N. Specific nuclear protein binding to a tri-partite negative regulatory element on the human CYP1A1 gene. Proceedings of the 83rd Annual Meeting Amer. Assoc. Cancer Res. 33:2171, 1992.
38. States, J.C., Hines, R.N., Novak, R.F. and Runge-Morris, M. Controlled expression of cytochrome P4501A1 in human cells transformed with an inducible expression construct. Proceedings of the 83rd Annual Meeting Amer. Assoc. Cancer Res. 33:179, 1992.
39. Sheehin, S.E., Stresser, D., Williams, D.E. and Hines, R.N. Tissue- and sex-dependent expression of the microsomal flavin-containing monooxygenase in rabbit. The Toxicologist 13:388, 1993.
40. Boucher, P.D., Ruch, R.J. and Hines, R.N. Characterization of the tri-partite negative regulatory element on the human CYP1A1 gene. The Toxicologist 13:432, 1993.
41. Thomsen, J.S., Wang, X., Hines, R.N. and Safe, S. Introduction of a functional human estrogen receptor restores the function of the Ah receptor in the human breast carcinoma cell line MDA-MB-231. The Toxicologist 13:34, 1993.
42. Hines, R.N., Shehin, S.E., Lee, M.-Y. and Williams, D.E. Tissue- and developmental-specific expression of flavin-containing monooxygenase in the rabbit. The Toxicologist 13:6, 1993.
43. Hines, R., Boucher, P. and Piechocki, M. Characterization of a negative regulatory element on the human CYP1A1 gene. FASEB J. 7:1167, 1993.
44. Thomsen, J.S., Wang, X., Hines, R.N. and Safe, S.H. Introduction of a functional estrogen receptor restores the function of the Ah receptor in the human breast carcinoma cell line, MDA-MB-231. J.Cell Biol S17A:130, 1993.
45. Ansari, S.A., Piechocki, M.P., Julkarni, J., Boucher, P.D., and Hines, R.N. Analysis of the human CYP1A1 negative regulatory element and its specific nuclear binding protein. The Toxicologist 14:141, 1994.
46. Boucher, P.D., Piechocki, M.P. and Hines, R.N. Analysis of human CYP1A1 NRE mutants in both in vitro and ex vivo systems. Proceedings of the 85th Annual Meeting Amer. Assoc. Cancer Res. 35:557, 1994.
47. Falkner, K.C., Linder, M.W., Hines, R.N. and Prough, R.A. Glucocorticoid responsive elements of the rat cytochrome P4501A1 and glutathione S-transferase Ya subunit genes. FASEB J. 8:1254, 1994.
48. Shehin-Johnson, S.E., Williams, D.E., Su, S., Stresser, D., Luo, Z. and Hines, R.N. Characterization of rabbit flavin-containing monooxygenase gene expression and isolation. FASEB J. 8:1423, 1994.
49. Hines, R.N., Boucher, P.D., Piechocki, M.P., Kulkarni, J. and Ansari, S.A. Negative regulation of human CYP1A1 gene expression. FASEB J. 8:1254, 1994.
50. Williams, D.E., Krueger, S., Yueh, M.-F., Su, S., Smiley, S., Kadkhodayan, S., Shehin-Johnson, S. and Hines, R.N. Flavin-containing monooxygenase (FMO) form 2 and serum levels of progesterone and cortisol during pregnancy in the rabbit. FASEB J. 8:1421, 1994.
51. Wang, W., Thomsen, J., Hines, R. and Safe, S. Regulation of CYP1A1 gene expression in the estrogen receptor negative Hs578T human breast cancer cell line. The Toxicologist 15:238 (Abstr. 1272), 1995.
52. Luo, Z. and Hines, R.N. Molecular cloning and characterization of the rabbit FMO1 gene. The Toxicologist 15:53 (Abstr. 283), 1995.
53. Hines, R.N. Xenobiotic metabolizing enzymes: Species differences in gene structure and regulation. The Toxicologist 15:174 (Abstr. 926), 1995.
54. Shehin-Johnson, S.E., Kollar, W.M., and Hines, R.N. Characterization of mammalian flavin-containing monooxygenase form 2 gene expression and gene structure. Proceedings of the 86th Annual Meeting Amer. Assoc. Cancer Res. 36:531 (Abstr. 3160), 1995.
55. Piechocki, M.P., Boucher, P.D. and Hines, R.N. Characterization of the human CYP1A1 repressor and negative regulatory element. Proceedings of the 86th Annual Meeting Amer. Assoc. Cancer Res. 36:531 (Abstr. 3161), 1995.
56. Wang, W., Thomsen, J., Moore, M., Wang, X., Hines, R. and Safe, S. Induction of CYP1A1 in estrogen receptor negative human breast cancer cells. Proceedings of the VII International Congress of Toxicology (Abstr. 25-PD-8), 1995.
57. Hines, R.N., Piechocki, M.P. and Boucher, P.D. Characterization of the human CYP1A1 repressor and negative regulatory element. Proceedings of the VII International Congress of Toxicology (Abstr. 25-PD-13), 1995.
58. Shehin-Johnson, S.E. and Hines, R.N. Analysis of the 5' Flanking Regions of the rabbit flavin-containing monooxygenase form 2 (FMO2) gene. The Toxicologist 30:329 (Abstr. 1690), 1996.
59. Luo, Z. and Hines, R. Molecular cloning and characterization of the rabbit flavin-containing monooxygenase isoform 1 gene. Proceedings of the 87th Annual Meeting Amer. Assoc. Cancer Res. 37:519 (Abstr. No. 3551), 1996.
60. Piechocki, M.P. Boucher, P.D. and Hines, R.N. Functional characterization of the human CYP1A1 negative regulatory element. Proceedings of the 87th Annual Meeting Amer. Assoc. Cancer Res. 37:526 (Abstr. No. 3601), 1996.
61. Rasheed, A., Hines, R.N., McCarver-May, D.G. Variation in induction of placental cytochrome P4502E1: Possible role in susceptibility to fetal alcohol syndrome. Pediatr. Res. 39:83A, 1996.
62. Hines, R.N., Shehin-Johnson, S.E., and Luo, Z. Regulation of Rabbit FMO1 and FMO2 Gene Expression. Proceedings of the 7th North American Meeting of the International Society for the Study of Xenobiotics 10:4 (Abstr. No. 4), 1996.
63. Luo, Z. and Hines, R.N. Identification and characterization of the rabbit flavin-containing monooxygeanse 1 gene. The Toxicologist 36:121 (Abstr. No. 620), 1997.
64. Piechocki, M.P. and Hines, R.N. Characrterization of the human CYP1A1 negative regulatory element. The Toxicologist 36:92 (Abstr. No. 472), 1997.
65. Rasheed A., Hines R.N., McCarver D.G. Variation in human placental CYP2E1: potential risk factor for growth retardation associated with intrauterine alcohol exposure. Alcohol Clin. Exp. Res. 21:53A, 1997.
66. Ledirac, N., Delescluse, C., de Sousa, G., Pralavorio, M., Hines, R. Lesca, P. and Rahmani, R. Suppression of CYP1A1 induction by diflubenzuron in human hepatic and epidermal cell lines. Proceedings of the 5th CFN Symposium: Effects of Toxicants on Gene Expression and Intracellular Signalling, in press.
67. Liu, L., El-Zaru, M., Hines, R.N. and Marsh, J.D. Cloning and analysis of the 5' untranslated region of the L-type calcium channel a1C subunit. J. Mol. Cell. Cardiol. 29: A156, 1997.
68. Liu, L., Cala, S.E., Hines, R.N. and Marsh, J.D. The DHP receptor protein in rat heart is expressed as the non-truncated full length form. J. Mol. Cell. Cardiol. 29: A157; 1997.
69. Luo, Z. and Hines, R.N. Identification and characterization of MED-1-like elements in the rabbit FMO1 gene promoter. Toxicol. Sci. 42(1S): 360 (Abstr. No. 1775), 1998.
70. Hines, R.N., Luo, Z., Whetstine, J., Yueh, M.-F., McCarver, D.G., and Williams, D.E. Regulation of the flavin-containing monooxygenase (FMOs): Tissue- and species-specificity. Exp. Toxic/.. Pathol. 50 (2): 108, 1998.
71. Hines, R.N., Smolinski, S.M. and Piechocki, M.P. The human CYP1A1 negative regulatory element is able to modulate Ah receptor mediated transcriptional activity. Toxicol. Lett. Supplement 1/95: 97 (Abstr. No. P2A21), 1998.
72. McCarver, D.G., Hines, R.N., Byun, R. and Hichme, M. CYP2E1 mutation associated with increased chlorzoxazone (CZ) metabolic ability. Toxicol. Lett. Supplement 1/95: 98 (Abstr. No. P2A22), 1998.
73. Luo, Z. and Hines, R.N. Molecular mechanisms for the tissue-specific expression of the rabbit flavin-containing monooxygenase 1 (FMO1) gene. Toxicolog. Sci. 48:165 (Abstr. No. 775), 1999.
74. Whetstine, J.R., Mercer, N.A., McCarver, D.G., Williams, D.E., Park, C.-S., Cha, Y.-N., and Hines, R.N. Flavin-containing monooxygenase 2: Polymorphism characterization and determination of allelic frequency in African Americans, Caucasians, and Asians. Toxicolog. Sci. 48:165 (Abstr. No. 774), 1999.
75. Smolinski, S.M., Garrett, C.M., Piechocki, M.P. and Hines, R.N. Competitive binding of positive- and negative-acting transcription factors to the human CYP1A1 negative regulatory element. Toxicolog. Sci. 48:164 (Abstr. No. 771), 1999.
76. Yueh, M.-F., Hines, R.N., Krueger, S.K. and Williams, D.E. Identification of a human lung FMO2 variant. Toxicolog. Sci. 48:227 (Abstr. No. 1067), 1999.
77. Hines, R.N., Luo, Z., and McNally, K. Molecular mechanisms controlling flavin-containing monooxygenase tissue-specific expression. FASEB J. 14: A1305 (Abstr. No. C3), 2000.
78. Luo, Z., Hopp, K.A. and Hines, R.N. Role of HNF1 and HNF4 in rabbit FMO1 gene regulation. Toxicolog. Sci., submitted.
79. Hines, R.N. and Luo, Z. Identification of tissue-selective transcription factors controlling rabbit FMO1 expression. FASEB J., submitted.
80. Koukouritaki, S.B., Yeung, C.K., Rettie, A.E., Williams, D.E. and Hines, R.N. Human flavin-containing monooxygenase 1 and 3 developmental expression. FASEB J., submitted.