Research
A strong research program is a major focus of the Department of Dermatology at the Medical College of Wisconsin. The department has programs in clinical, translational, and basic research. Fellowships are offered in immunodermatology, clinical research, autoimmune diseases affecting the skin, and pediatric dermatology. Trainees in the research laboratories learn a wide variety of molecular biology and cell biology techniques that are applied to the study of skin disorders. Pediatric dermatology fellows participate in clinical projects related to cutaneous disorders of children.
Clinical Research
Clinical research projects include the origin and significance of midline congenital defects in children as well as research into the origin and classification of vascular malformation and hemangiomas in infants and children. Departmental resources and industry partners support a series of studies regarding new therapeutic agents for adults and children with various skin diseases.
Recent Clinical Research Publications from Faculty Members
Chiu YE, Drolet BA, Duffy KJ, Holland KE. A case of ankyloblepharon, ectodermal dysplasia, and cleft lip/palate syndrome with ectrodactyly: Are the p63 syndromes distinct after all? Pediatric
Dermatology (in press).
Garzon MC, Drolet BA, Baselga E, Chamlin SL, Haggstrom AN, Horii K, Lucky AW, Mancini AJ, Metry DW, Newell B., et al. Comparison of infantile hemangiomas in preterm and term infants: A prospective study. Archives of Dermatology, 2008; 144:1231-1232.
Duffy KJ, Littrell J, Locke A, Sherman SL, Olivier M. A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay. Nucleic Acids Res, 2008; 36(22): e145.
Hwang ST, Janik JE, Jaffe ES, Wilson WH. Mycosis Fungoides and Sézary Syndrome. Lancet, 2008; 371:945-57.
Olasz EB, Yancey KB. Bullous pemphigoid and related subepidermal autoimmune blistering diseases. Curr Dir Autoimmun, 2008; 10:141-66. Review.
Chamlin SL, Haggstrom AN, Drolet BA, Baselga E, Frieden IJ, Garzon MC, Horii KA, Lucky AW, Metry DW, Newell B., et al. Multicenter prospective study of ulcerated hemangiomas. Journal of Pediatrics, 2007; 684-689, 689 e681.
Cowen EW, Liu CW, Steinberg SM, Kang SW, Vonderheid EC, Kwak HS, Booher S, Petricoin EF, Liotta LA, Whiteley G, Hwang ST. Differentiation of tumor-phase mycosis fungoides, psoriasis vulgaris, and normal controls in a pilot study using serum proteomic analysis. Brit. J. Dermatol, 2007; 157: 946-53.
Neuburg M: Transplant associated skin cancer – the role of reducing immunosuppression. Journal of the National Comprehensive Cancer Network, 2007; 5(5):541-9.
Rhee JS, Matthews BA, Neuburg M, Logan BR, Burzynski M, Nattinger AB: Validation of a quality-of-life instrument for patients with nonmelanoma skin cancer. Archives of Facial Plastic Surgery, 2006; 8(5):314-8.
Jaber SH, Cowen EW, Haworth LR, Booher SL, Berman DM, Rosenberg SA, Hwang ST. Skin reactions in a subset of stage IV melanoma patients treated with anti-CTLA-4 monoclonal antibody as a single agent. Arch. Dermatolol, 2006; 142: 166-72. (Cover Image)
Fleming MG, Steger C, Zhang J, Gao J, Cognetta AB, Pollak I, Dyer C. Techniques for a structural analysis of dermatoscopic imagery. Computerized Medical Imaging and Graphics, 1998; 22:375-389.
Maronn ML, Corden T, Drolet BA. Pneumocystis carinii pneumonia in infant treated with oral steroids for hemangioma. Arch Dermatol, 2007; 143(9):1224-1225. No abstract available.
Basic Science Research
The basic science focus of the department concerns autoimmunity, molecular biology and cell biology. Departmental faculty members hold active grants from the Dermatology Foundation, the National Institutes of Health, and the Department of Veterans Affairs.
Recent Basic Research Publications from Faculty Members
Lazarova Z, Salato VK, Lanschuetzer CM, Janson M, Fairley JA, Yancey KB. IgG anti-laminin 332 autoantibodies are present in a subset of patients with mucous membrane, but not bullous pemphigoid. J Am Acad Dermatol, 2008; 58:951-958.
Huang V, Lonsdorf AS, Fang L, Kakinuma T, Lee VC, Cha E, Zhang H, Nagao K, Zaleska M, Olszewski WL, Hwang ST. Cutting Edge: Rapid accumulation of epidermal CCL27 in skin-draining lymph nodes following topical application of a contact sensitizer recruits CCR10-expressing T cells. J. Immunol, 2008; 180: 6462-6.
Olasz EB, Roh J, Yee CL, Arita K, Akiyama M, Shimizu H, Vogel JC, Yancey KB: Human Bullous Pemphigoid Antigen 2 Transgenic Skin Elicits Specific IgG in Wild-Type Mice. J Invest Dermatol, 2007; 127(12):2807-17.
Petersen MC, Lazar J, Jacob HJ, Wakatsuki T. Tissue engineering: a new frontier in physiological genomics. Physiol Genomics, 2007; 32(1): 28-32. Epub 2007 Oct 23. Review
Publications