Jack Kleinman, M.D. Professor of Medicine Nephrology
Education: Columbia University, NY, B.A. New York University School of Medicine, M.D.
Link to Nephrology NIH BIOSKETCH
|The Kleinman-Wesson Lab|
Our laboratories conduct studies on the physical, chemical and physiologic mechanisms of crystal nucleation, growth, and aggregation of crystals and attachment of crystals to cell surfaces that cause disease in humans, with primary focus on factors that cause renal stone disease. Current projects related to stone formation include: 1) Studies on the interaction of macromolecules with the surface of crystals that form to define the potential influence of functional groups to arrest the processes of crystal aggregation and attachment to cell surfaces, 2) Studies to define the molecules on cells that are responsible for the attachment of crystals to renal cells. 3) Studies on the use of artificial homopolymers to inhibit calcium oxalate and other crystal retention and stone formation in animal models of stone disease, and 4) Studies on urinary proteins in families of calcium oxalate stone formers to test for heritability of phenotypes related to stone formation. Finally, we are conducting studies on the determinants of vascular calcification in animal models of chronic kidney disease.