Cell Biology, Neurobiology & Anatomy

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Edgar A. DeYoe, PhD
Professor

Department of Radiology and
Department of Cell Biology, Neurobiology and Anatomy
Associate Professor, Department of Biophysics


Mailing Address:
Department of Radiology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509

Phone: (414) 456-4920
Email: deyoe@mcw.edu

 Edgar A. DeYoe, PhD

Education:
PhD, Lehigh University, Bethlehem, PA, 1983
Postdoctoral, California Institute of Technology

Graduate Programs:
Program in Cell and Developmental Biology
Program in Neuroscience

Research Area: Functional neuroimaging (FMRI) of brain systems responsible for sensory perception, especially vision, and brain-related sensory pathology

 

The goal of our research is to understand the neurophysiological basis of normal visual perception and brain-related visual pathology. More generally, we study the visual system as a model of cerebral function through which we gain insight into the more universal mechanisms of sensory perception and its control by attention. A central puzzle of visual perception is that the lens of the eye produces only flat images of the world on the layer of photoreceptors at the back of the eye, yet the brain somehow interprets these images to yield our dynamic, colorful, 3-dimensional visual perceptions. Though much is known about the early stages of visual processing in the brain, far less is understood about advanced stages of visual processing in the cerebral cortex, especially in humans. Consequently, we are using functional magnetic resonance imaging (FMRI), to obtain high quality images of human brain activity. We use these images to identify different areas of the cerebral cortex that contribute to vision. We have been able to make brain maps of 8-10 different visual areas in the human. We expect that there are quite a few more to be discovered since other primates (e.g. macaque monkeys) have over 30. Each of these areas may be specialized to deal with different attributes of the visual world such as color, form, movement and location. However, at any one moment, we typically direct our attention just to those objects and features that interest us. FMRI lets us explore how a change in the subject's focus of attention modifies brain activity. Insights from these experiments then allow us to make predictions about visual capacities and deficits in clinical patients who have suffered damage to specific areas of the cortex. This work is funded by grants from the National Institute of Health (NIH).

 

 "There is nothing like being on the forefront of knowledge, standing at the edge and knowing that you are seeing something that no one else has ever seen before."

 

Selected Publications: 

Medler K, Ulmer J, and EA1 DeYoe: Using FMRI to distinguish visuospatial neglect from sensory loss. Neurosurgery In Revision, 2006.

Szeder V, et al.: FMRI shows additional functional visual field loss in preopperative mapping of an occipital AVM. Neurosurgery Accepted, 2006.

Lewis JW, Phinney RE, Brefczynski-Lewis JA, and EA DeYoe: Lefties get it "right" when hearing tool sounds. J Cogn Neurosci 18(8):1314-30, 2006.

Lewine JD, Doty RW and EA DeYoe: Laminar variation in threshold for detection of electrical excitation of striate cortex by macaques. J Neurophysiol 94(5):3443-50, 2005.

Bartlett JR, Doty RW, Lee BB, Lewine JD, Negrao N, Overman, WH and EA DeYoe: Psychophysics of electrical stimulation of striate cortex in macaques. J Neurophysiol 94(5):3430-42, 2005.

Lewis JW, Brefczynski JA, Phinney RE, Janik JJ and EA DeYoe: Distinct cortical pathways for processing tool versus animal sounds. J Neuroscience 25(21):5148-58, 2005.

Ulmer JL:, Hacein-Bey L, Mathews VP, Mueller WM, Prost RW, Meyer GA, Krouwer HG, Schmainda KM and EA DeYoe: Lesion-induced pseudo-dominance at functional magnetic resonance imaging: implications for preoperative assessments. Neurosurgery 55(3):569-79; discussion 580-1, 2004.

Salvan CV, Ulmer JL, Wascher T, Mathews VP, Lewis JW, Prost RW and EA DeYoe: Visual object agnosia and pure word alexia: correlation of functional magnetic resonance imaging and lesion localization. J Comput Assist Tomogr 28(1):63-7, 2004.

Lewis JW, Wightman FL, Brefczynski JA, Phinney RE, Binder JR and EA DeYoe: Human Brain Regions Involved in Recognizing Environmental Sounds. Cereb Cortex 14(9):1008-21, 2004.

Huddleston, WE & EA DeYoe: First-order and second-order spectral 'motion' mechanisms in the human auditory system. Perception 32(9):1141-9, 2003.

Saad ZS, KM Ropella, PA Bandetti and EA DeYoe: The spatial extent of the BOLD response. Neuroimage 19(1):132-44, 2003.

Saad ZS, KM Ropella and EA DeYoe: Estimation of FMRI response delays. Neuroimage 18:494-504, 2003.

Saad ZS, KM Ropella, RW Cox and EA DeYoe: Analysis and use of FMRI response delays. Hum Brain Map 13:74-93, 2001.

Lewis JW, MS Beauchamp and EA DeYoe: A comparison of visual and auditory motion processing in human cerebral cortex. Cereb Cortex 10:873-88, 2000.

Lewis JW, MS Beauchamp and EA DeYoe: A comparison of visual and auditory motion processing in human cerebral cortex. Cerebral Cortex 10:873-888, 2000.

Beauchamp MS, JV Haxby, AC Rosen and EA DeYoe: A functional MRI case study of acquired cerebral dyschromatopsia. Neuropsychologia 38:1170-1179, 2000.

Beauchamp MS, JV Haxby, J Jennings and EA DeYoe: An FMRI version of the Farnsworth-Munsell 100-Hue Test reveals multiple color-selective areas in human ventral occipitotemporal cortex. Cerebral Cortex 9:257-263, 1999.

Brefczynski JA and EA DeYoe: A physiological correlate of the spotlight of visual attention. Nature Neuroscience 2:370-374, 1999. [original press release]

Beauchamp MS, RW Cox and EA DeYoe: Graded effects of spatial and featural attention on human area MT and associated motion processing areas. J Neurophysiology 78:516-520, 1997.

Biswal B, EA DeYoe and JS Hyde: Reduction of physiological fluctuations in FMRI using digital filters. Magnetic Resonance in Medicine 35:107-113, 1996.

DeYoe EA, G Carman, P Bandettini, S Glickman, R Cox, D Miller and J Neitz: Mapping striate and extrastriate visual areas in human cerebral cortex. Proc National Academy of Sciences 93:2382-2386, 1996.

DeYoe EA, TC Trusk and MTT Wong-Riley: Activity correlates of cytochrome oxidase-defined compartments in granular and supragranular layers of primary visual cortex of the macaque monkey. Visual Neuroscience 12:629-639, 1995.

DeYoe EA, DJ Felleman, DC Van Essen, and McClendon: Anatomical basis of concurrent processing streams in visual area V4 and inferotemporal cortex of the macaque monkey. Nature 371:151-154, 1994.

DeYoe EA, P Bandettini, J Neitz, D Miller and P Winans: Ffunctional magnetic resonance imaging (FMRI) of the human brain. J Neuroscience Methods 54:171-187, 1994.

Olavarria JF, EA DeYoe, JJ Knierim, JM Fox and DC Van Essen: Neural responses to visual texture patterns in middle temporal area of the macaque monkey. J Neurophysiology 68:164-181, 1992.

Van Essen DC, DJ Felleman, EA DeYoe, J Olavarria and J Knierim: Modular and hierarchical organization of extrastriate visual cortex in the macaque monkey. Cold Spring Harbor Symposia on Quantitative Biology Vol. LV. Cold Spring Harbor Laboratory Press 55:679-696, 1990.

DeYoe EA, S Hockfield, H Garren and DC Van Essen: Antibody labeling of functional subdivisions in visual cortex: Cat-301 immunoreactivity in striate and extrastriate cortex of the macaque monkey. Visual Neuroscience 5:67-81, 1990.

DeYoe EA, J Lewine and RW Doty: Optimal stimuli for detection of intracortical currents applied to striate cortex of awake macaque monkeys. Proc of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 11:934-936, 1989.

DeYoe EA and DC Van Essen: Concurrent processing streams in monkey visual cortex. Trends in Neurosci 11:219-226, 1988.

DeYoe EA and DC Van Essen: Segregation of efferent connections and receptive field properties in visual area V2 of the macaque. Nature 317: 58-61, 1985.

DeYoe EA: An investigation in the awake macaque of the threshold for the detection of electrical currents applied to striate cortex: Psychophysical properties and laminar differences. Ph.D. Thesis, University of Rochester, 1983.

DeYoe EA and JR Bartlett: Rarity of luxotonic units in cortical visual areas of the cat. Exper Brain Res 39:125-132, 1980.

Altenor A and EA DeYoe: The effects of DL-p-chlorophenylalanine on learned helplessness in the rat. Behavioral Biol 20:111-115, 1977.

DeYoe EA: An investigation of a possible serotonergic modulatory input to the auditory system. Masters Thesis, Lehigh University, 1976.

DeYoe EA and HG Foster: Low cost neural spike window discriminator with digit readout. Physiol and Behavior 16:371-373, 1976.

 

 

 

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