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Depressants produce central nervous system depression.  Depressants (i.e., barbiturates, benzodiazepines, glutethimide, methaqualone, and meprobamate) can cause physical and psychological dependence that can lead to respiratory depression, coma and death, especially when used simultaneously with alcohol.  Withdrawal can lead to restlessness, insomnia, convulsions and even death.  Chloral hydrate, a hypnotic depressant, and alcohol constitute the infamous date rape drug or "Mickey Finn."
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Page Updated 11/20/2013