Medical Scientist Training Program

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Annual Visiting Alumnus

 

Matt Anderson, MD, PhD
 

Matt is currently an Assistant Professor of Pathology and the Assistant Director of the Histocompatibility, Immunogenetics, and Disease Profiling Laboratory in the Department of Pathology, at the Stanford University School of Medicine.

Matt was our featured guest speaker at our MSTP Graduation dinner held at the University Club in downtown Milwaukee.  Having graduated six years prior, the graduating students knew him and that added a special connection to the evening.  Matt gave an excellent talk that intertwined a bit of his life while in the program while giving his perspective on where the physician-scientist's role in the US may be headed in the next ten years. His talk was heartfelt and insightful.

Matt's research interests include the use of high-throughput sequencing technologies for clinical diagnostics and biomarker discovery, focused on transplantation and immunology.  While on campus, Matt also gave a seminar entitled “Next-Generation Sequencing for Clinical HLA Genotyping."  When describing his work, he stated: "Human leukocyte antigens (HLA) are proteins that are the key molecular determinants of the adaptive immune response, and also control the host immune response to bone marrow and solid-organ transplants. Clinically, the success of a transplant critically depends on a high degree of similarity between the HLA molecules of the donor and recipient. However, HLA genes are the most polymorphic genes in the human genome, complicating our efforts to genotype patients using current DNA sequencing technology. Newer high-throughput sequencing technologies offer the potential to improve the accuracy of HLA genotyping by virtue of clonal template amplification and sequencing. In the future, we plan to use high-throughput sequencing technologies to analyze other genes important for the immune response to transplants, characterize transplant-related viruses, and monitor patients for rejection."

Of his time here, Matt said: "It was great to come back to MCW and reconnect with so many friends from the MSTP. I am happy to see that the Program is growing and thriving, and that is a real testament to the hard work and dedication of the MSTP leadership and the quality of the trainees."

 

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