Division of Pediatric Surgery
GRANT RESEARCH
Pediatrics
12/1/2001- 11/30/2005
P.I. John E. Baker, PhD
C.I. Parvaneh Rafiee, PhD
NIH-NHLBI CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
This grant determines whether protein kinases contribute to cardioprotection in chronically hypoxic rabbit and human hearts.
NIH-NHLBI
9/30/2000- 8/31/2004
P.I. John E. Baker, PhD
C.I. Parvaneh Rafiee, PhD
GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
Investigates the gene(s) responsible for adaptation to intermittent hypoxia that causes susceptibility to myocardial ischemia.
NIH/NHLBI
8/1/2001-
P.I. William M. Chilian, PhD
C.I. John E. Baker, PhD
SCOR - ISCHEMIC HEART DISEASE IN BLACKS
This is a multidisciplinary approach to investigate ischemic heart disease in African Americans.
NIH
1/1/2003-
P.I. Garrett J. Gross, PhD
C.I. John E. Baker, PhD
EFFECT OF DRUGS UPON MYOCARDIAL HYPOXIA
Investigates activation of opioid receptors results in acute or delayed cardioprotection that is mediated by the mitochondrial KATP channel.
HHS; HRSA; MCHB; Emergency Medical Services for Children Program
9/1/2002- 8/31/2004
P.I. Karen Guice, MD
NATIONAL TRAUMA REGISTRY FOR CHILDREN: DATA IDENTIFICATION, COLLECTION AND USE
The primary goal of this project is to plan and design a national data registry for injured children in the United States.
NIH/NHLBI
7/1/2002- 6/30/2007
P.I. David R. Harder, PhD
C.I. Kirkwood Pritchard, PhD
VASCULAR SIGNALING BY FREE RADICALS PROJECT #1
The major goals of the project are to define the actions of reactive oxygen species in the initiating or modifying signaling events that regulate cerebral blood flow.
NIH
7/1/2002- 6/30/2007
P.I. David R. Harder, PhD
C.I. Kirkwood Pritchard, PhD
VASCULAR SIGNALING BY FREE RADICALS PROJECT #2
The major goals of the project are to determine the mechanisms by which H2O2 mediates flow induced dilation, identify key enzymes that generate ROS and the intracellular signaling pathways involved.
NIH
8/1/2001-
P.I. Howard J. Jacob, PhD
C.I. John E. Baker, PhD
PHYSIOGENOMICS OF STRESSORS IN DERIVED CONSOMIC RATS
The goal of the PGA is to look, on a genomic side, at the resources and tools of the Human Genome project to major biological processes involved in cardiovascular, renal and hematologic function and dysfunction.
NIH
7/1/2002- 6/30/2007
P.I. Ganesh Konduri, MD
C.I. Kirkwood Pritchard, PhD
REGULATION OF PULMONARY CIRCULATION IN FETUS AND NEWBORN
The major goals of the project are to determine the mechanisms by which primary pulmonary hypertension in neonatal sheep impairs vasorelaxation.
NHLBI
6/1/2001- 6/1/2005
P.I. Kirkwood Pritchard, PhD
NATIVE LDL, CHOLESTEROL AND IMPAIRED VASORELAXATION
The major goals of the project are to determine the mechanisms by which radicals species are generated by vascular endothelium exposed to native LDL and cholesterol.
NIH-NHLBI
8/1/2003- 7/31/2006
P.I. Kirkwood Pritchard, PhD
C.I. Parvaneh Rafiee, PhD
C.I. Yang Shi, PhD
HSP90 MEDIATES ENOS AND VASCULAR FUNCTION
This grant is to elucidate the mechanisms by which heat shock protein 90 (Hsp90) modulates endothelial nitric oxide synthase function.
CHW
1/1/2004- 12/31/2005
P.I. Tara Sander, PhD
C.I. James Tweddell, MD
ROLE OF PPAR-GAMMA IN HEART VALVE FORMATION
The goal of this project is to investigate mechanisms that mediate heart valve formation and the pathogenesis of valvular heart disease.
Research Affairs, MCW
7/1/2004-6/30/2005
P.I. Tara Sander, PhD
C.I. Brian F. Volkman, PhD
STRUCTURE AND FUNCTION OF THE ZNF42 SCAN DOMAIN
The major goal of this project is to investigate mechanisms that mediate heart valve formation and the pathogenesis of vascular heart disease.
American Heart Assoc.
7/1/2003- 6/30/2005
P.I. Yang Shi, PhD
INCREASED RESISTANCE TO MYOCARDIAL ISCHEMIA IN THE BROWN NORWAY VS DAHL S RAT: ROLE OF NITRIC OXIDE SYNTHASE AND HSP90
This grant determines the cellular mechanisms that make hearts from BN/Mcw rats more resistant to global ischemia than hearts from SS/Mcw rats.
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