David G. Binion, MD Publication
MANUSCRIPTS
1. Binion DG, Theriot KR, Shidham S, Lundeen S, Hatoum O, Lim HJ, Otterson MF. “Clinical Factors Contributing to Rapid Reoperation for Crohn's Disease Patients Undergoing Resection and/or Strictureplasty.” J Gastrointest Surg. 17; 2007 [Epub ahead of print]
2. Ananthakrishnan AN, McGinley EL, Binion DG. “Excess hospitalization burden associated with Clostridium difficile in patients with Inflammatory Bowel Disease.” Gut. [Epub ahead of print] 2007.
3. Kugathasan S Md, Sauberman L, Smith L, Kou D, Itoh J, Binion D, Levine A, Blumberg R, Fiocchi C. “Mucosal t-cell immunoregulation varies in early and late Crohn's disease.” Gut. [Epub ahead of print] 2007.
4. Ananthakrishnan AN, Attila T, Otterson MF, Lipchik RJ, Massey BT, Komorowski RA, Binion DG. “Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease.” J Clin Gastroenterol. 41:682-8, 2007.
5. SJ Lundeen, MF Otterson, DG Binion, ET Carman, WJ Peppard: Clostridium difficile Enteritis: An Early Postoperative Complication in Inflammatory Bowel Disease. J Gastrointest Surg; 11(2): 138-42, 2007.
6. M Issa, A Vijayapal, MB Graham, DB Beaulieu, MF Otterson, S Lundeen, S Skaros, LR Weber, RA Komorowski, JF Knox, J Emmons, JS Bajaj, DG Binion: Impact of Clostridium difficile on inflammatory bowel disease. Clin Gastroenterol Hepatol; 5(3): 345-51, 2007
7. S Horowitz, DG Binion, V Nelson, Y Kanaa, P Javadi, Z Lazarova, C Andrekopoulos, B Kalyanaraman, MF Otterson, P Rafiee: Increased Arginase Activity And Endothelial Dysfunction In Human Inflammatory Bowel Disease. Am J Physiol Gastrointest Liver Physiol; Jan 11, 2007.
8. OA Hatoum, J Heidemann, DG Binion: The intestinal microvasculature as a therapeutic target in inflammatory bowel disease. Ann N Y Acad Sci; 1072: 78-97, 2006.
9. J Heidemann, DG Binion, W Domschke, T Kucharzik: Antiangiogenic therapy in human gastrointestinal malignancies. Gut; 55(10): 1497-511, 2006.
10. P Rafiee, ME Theriot, VM Nelson, J Heidemann, Y Kanaa, SA Horowitz, A Rogaczewski, CP Johnson, I Ali, R Shaker, DG Binion: Human Esophageal Microvascular Endothelial Cells (HEMEC) Respond to Acidic pH Stress by PI3K/Akt and p38 MAPK Regulated Induction of Hsp70 and Hsp27. Am J Physiol Cell Physiol; 291(5):C931-45, 2006.
11. RK Cross, DG Binion: Narcotic use in patients with Crohn’s disease: reply from Drs. Cros and Binion. Am J Gastroenterol. 101(6): 1397-8, 2006.
12. V Tonkovic-Capin, SS Galbraith, RS Rogers, 3rd, DG Binion, KB Yancey: Cutaneous Crohn's disease mimicking Melkersson-Rosenthal syndrome: treatment with methotrexate. J Eur Acad Dermatol Venereol. 20(4): 449-52, 2006.
13. MK Wendt, PA Johanesen, N Kang-Decker, DG Binion, V Shah, MB Dwinell: Cutaneous Crohn's disease mimicking Melkersson-Rosenthal syndrome: treatment with methotrexate. J Eur Acad Dermatol Venereol. 20(4): 449-52, 2006.
14. DG Binion, S Kugathasan, MB Dwinell: Molecular stratification of Crohn's disease by chemokine receptors: fractalkine receptor polymorphisms define a fibrostenosing ileal subgroup. Am J Gastroenterol, 101(1): 107-9, 2006.
15. J Heidemann, C Maaser, A Lugering, TW Spahn, KP Zimmer, H Herbst, P Rafiee, W Domschke, CF Krieglstein, DG Binion, TF Kucharzik: Expression of vascular cell adhesion molecule-1 (CD 106) in normal and neoplastic human esophageal squamous epithelium. Int J Oncol., 28(1):77-85, 2006.
16. OA Hatoum, DG Binion, SA Phillips, C O’Loughlin, RA Komorowski, DD Gutterman, MF Otterson: Radiation induced small bowel “web” formation is associated with acquired microvascular dysfunction. Gut., 54(12):1797-800, 2005.
17. RK Cross, KT Wilson, DG Binion: Narcotic use in patients with Crohn’s Disease. Am J Gastroenterol., 100(10):2225-9, 2005.
18. OA Hatoum, DG Binion, DD Gutterman: Paradox of simultaneous intestinal ischaemia and hyperaemia in inflammatory bowel disease. Eur J Clin Invest., 35(10):599-609, 2005.
19. OA Hatoum, KM Gauthier, DG Binion, H Miura, G Telford, MF Otterson, WB Campbell, DD Gutterman: Novel Mechanism of Vasodilation in Inflammatory Bowel Disease. Arterioscler Thromb Vasc Biol., 25(11):2355-61, 2005.
20. OA Hatoum, DG Binion, SA Phillips, C O’loughlin, RA Komorowski, DD Gutterman, MF Otterson: Radiation induced small bowel “web” formation is associated with acquired microvascular dysfunction. Gut, 15(42): 1797-800, 2005.
21. ML Seymour, DG Binion, SJ Compton, MD Hollenberg, WK Macnaughton: Expression of proteinase-activated receptor 2 on human primary gastrointestinal myofibroblasts and stimulation of prostaglandin synthesis. Can J Physiol Pharmacol., 83(7):605-16, 2005.
22. R Cross, KT Wilson, DG Binion: Polypharmacy and Crohn's disease. Aliment Pharmacol Ther, 21(10):1211-6, 2005.
23. JS Bajaj, K Saeian, RR Varma, J Franco, JF Knox, J Podoll, J Emmons, M Levy, DG Binion: Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: A tertiary referral center experience. Am J Gastroenterol, 100(5):1121-5, 2005.
24. U Mahadevan, S Kane, WJ Sandborn, RD Cohen, K Hanson, JP Terdiman, DB Binion: Intentional infliximab use during pregnancy for induction or maintenance of remission in Crohn's disese. Aliment Pharmacol Ther, 21(6):733-8, 2005.
25. OA Hatoum, DG Binion: The Vasculature and Inflammatory Bowel Dsiease: Contribution to Pathogenesis and Clinical Pathology. Inflamm Bowel Dis, 3:304-313, 2005.
26. T Attila, RS Hellman, AZ Krasnow, CL Hofmann, K Saeian, KS Dua, DG Binion, R Shaker: Feasibility and safety of endoscopic evaluation of gastric emptying. Endoscopy, 37(3):240-3, 2005.
27. OA Hatoum, KS Spinelli, M Abu-Hajir, T Attila, J Franco, MF Otterson, GL Telford, DG Binion: Mesenteric venous thrombosis in inflammatory bowel disease. J Clin Gastroenterol, 39(1):27-31, 2005.
28. H Ogawa, DG Binion: Effect of enteric flora on inflammatory and angiogenic mechanisms in human intestinal microvascular endothelial cells. Front Biosci, 10:94-8, 2005.
29. H Ogawa, DG Binion, J Heidemann, M Theriot, PJ Fisher, NA Johnson, MF Otterson: Mechanisms of MAdCAM-1 gene expression in human intestinal microvascular endothelial cells. AM J Physiol. Cell Physiol, 288(2):C272-81, 2005.
30. OA Hatoum, DG Binion, MF Otterson, M Hiroto, TL Telford: Role of hydrogen peroxide in ACh-induced dilation of human submucosal intestinal microvessels. Am J Physiol Heart Circ Physiol, 288(1):H48-54, 2005.
31. JM Smith, PA Johanesen, MK Wendt, DG Binion, MB Dwinell, CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cells migration and promotion of intestinal barrier integrity. Am J Physiol Gastrointest Liver Physiol, 288(2):G316-26, 2005.
32. MF Otterson, SJ Lundeen, KS Spinelli, GS Sudakoff, GL Telford, OA Hatoum, K Saeian, H Yun, DG Binion: Radiographic under estimation of small bowel stricturing Crohn’s disease: A comparison with surgical findings. Surgery, 136(4):8564-60, 2004.
33. P Rafiee, J Heidemann, H Ogawa, NA Johnson, PJ Fisher, MS Li, MF Otterson, CP Johnson, DG Binion: Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human microvascular endothelial cells by altered intracellular signaling. Cell Commun Signal, 2;2(1):3; 2004.
34. C Maaser, J Heidemann, C Von Eiff, A Lugering, TW Saphn, DG Binion, W Domschke, N Lugering, T Kucharzik: Human intestinal microvascular endothelial cells express toll-like receptor 5: a binding partner for bacterial flagellin. J Immunol, 172(8): 5056-62, 2004.
35. J Heidemann, H Ogawa, P Rafiee, N Lugering, C Maaser, W Domschke, DG Binion, MB Dwinell: Mucosal Angiogenesis Regulation by CXCR4 and its Ligand CXCL12 Expressed by Human Intestinal Microvascular Endothelial Cells. Am J Physiol Gastrointest Liver Physiol, 286(6):G1059-68, 2004.
36. J Heidemann, H Ogawa, MF Otterson, VB Shidham, DG Binion: Antiangiogenic Treatment of mesenteric desmoid tumors with toremifene and interferon alfa-2b: report of two cases. Dis Colon Rectum, 47(1):118-22; 2004.
37. GS Tay, DG Binion, D Eastwood, MF Otterson: Multivariate analysis suggests improved peri-operative outcome in Crohn's disease patients receiving immunomodulator therapy following segmental resections and/or stricureplasty. Surgery, 134(4):565-72; 2003.
38. H Ogawa, P Rafiee, PJ Fisher, NA Johnson, MF Otterson, DG Binion: Sodium butyrate inhibits angiogenesis of human intestinal microvascular endothelial cells through COX-2 inhibition. FEBS Lett, 6; 554(1-2): 88-94; 2003.
39. S Kugathasan, RH Judd, RG Hoffmann, J Heikenen, G Telega, F Khan, S Weisdorf-Schindele, W Son Pablo, Jr, J Perrault, R Park, M Yaffe, C Brown, MT Rivera-Bennett, I Halabi, A Martinez, E Blank, SL Werlin, CD Rudolph, DG Binion; Wisconsin Pediatric Inflammatory Bowel Disease Alliance: Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr, 143(4): 525-31; 2003.
40. OA Hatoum, H Miura, DG Binion: The vascular contribution in the pathogensis of inflammatory bowel disease. Am J Physiol Heart Circ, 285(5): H1791-6; 2003
41. H Ogawa, P Rafiee, PJ Fisher, NA Johnson, MF Otterson, DG Binion: Butyrate modulates gene and protein expression in human intestinal endotheal cells. Biochem Biophys Res Commun, 309(3):512-9; 2003.
42. P Rafiee, H Ogawa, J Heidemann, MS Li, M Aslam, TH Lamirand, PJ Fisher, SJ Graewin, MB Dwinell, CP Johnson, R Shaker, DG Binion: Isolation and characterization of human esophageal microvascular endothelial cells: Mechanisms of inflammatory activation. Am J Physiol Gastrointest Liver Physio, 285(6): G1277-92; 2003.
43. S Kugathasan, A Miranda, J Nocton, BA Brolet, C Raasch, DG Binion: Dermatological manifestations of Crohn's disease in children: Response to infliximab therapy. J Ped Gastroenterol Nutr; 37(2):150-4, 2003.
44. OA Hatoum, DG Binion, MF Otterson, D Gutterman. Acquired Microvascular dysfunction in human inflammatory bowel disease: Loss of nitric oxide mediated vasodilation. Gastroenterology, 125(1):58-69; 2003.
45. DN Prajapati, JF Knox, J Emmons, K Saeian, ME Csuka, DG Binion: Leflunomide treatment of Crohn's disease patients intolerant to standard immunomodulator therapy. J Clin Gastroenterol, 37(2):125-8; 2003.
46. DT Book, JP McNamar, TL Smith, RJ Toohill, K Saeian, DG Binion: Chronic Sinonasal Disease in Patients with Inflammatory Bowel Disease. Am J Rhinol, 17(2): 87-90, 2003.
47. H Ogawa, P Rafiee, J Heidemann, PJ Fisher, NA Johnson, MF Otterson, B Kalyanaraman, KA Pritchard Jr., DG Binion: Mechanisms of Endotoxin Tolerance in Human Intestinal Microvascular Endothelial Cells. J Immunol, 170(12):5956-5964; 2003.
48. J Heidemann, KS Spinelli, MF Otterson, DG Binion: Case Report: Magnetic Resonance Imaging in the diagnosis of epidural abscess complicating perirectal fistulizing Crohn's disease. Inflamm Bowel Dis, 9(2):122-4; 2003.
49. DN Prajapati, K Saeian, DG Binion, DM Staff, JP Kim, BT Massey, WJ Hogan: Volume and yield of screening colonoscopy at a tertiary medical center following change in medicare reimbursement. Am J Gastroenterol, 98(1):194-9, 2002.
50. J Heidemann, H Ogawa, MB Dwinell, P Rafiee, C Maaser, HR Gockel, MF Otterson, DM Ota, N Lügering, W Domschke, DG Binion: Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. J Biol Chem, 7: 278; 8508-15, 2003.
51. DN Prajapati, JP Kim, KS Spinelli, G Sudakoff, ET Stewart, RA Komorowski, GL Telford, DG Binion: Case Report: “Popcorn” Dystrophic Ileal Calcification in a Patient with Crohn's Disease. Inflamm Bowel Dis, 9(1):25-27, 2003.
52. JP Maloney, TA Ryan, KJ Brasel, DG Binion, DR Johnson, AC Halbower, EH Frankel, M Nyffeler, M Moss: Food dye use in enteral feedings: a review and a call for a moratorium. Nutr Clin Pract. 2002 Jun;17(3):169-81.
53. Y Chai, DG Binion, R Macklis, G Ghisolm III: Smooth muscle cell proliferation induced by oxidized LDL-borne lysophosphatidylcholine: evidence for FGF-2 release from cells not extracellular matrix. Vascul Pharmacol, 38:229-37, 2002.
54. K Saesian, D Staff, J Knox, DG Binion, W Townsend, K Due, R Shaker: Unsedated transnasal EGD (T-EGD): A new technique for accurately detecting and grading esophageal varices in cirrhotic patient. Am J Gastroenterol, 97:2246-2249, 2002.
55. P Rafiee, CP Johnson, MS Li, H Ogawa, J Heidemann, PJ Fisher, TH Lamirand, MF Otterson, KT Wilson, DG Binion: Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS: Paradoxical pro-inflammatory effect on the microvascular endothelium. J Biol Chem, 277:35605-35615, 2002.
56. S Kugathasan, M Levy, K Saeian, S Vasilopoulos, JP Kim, DN Prajapatie, J Emmons, A Martinez, K Kelly, DG Binion: Infliximab re-treatment in Crohn's disease adults and children: Risk factors for the development of delayed severe systemic reaction. Am J Gastroenterol, 97: 1408-1414, 2002.
57. DN Prajapati, JR Newcomer, J Emmons, M Abu-Hajir, DG Binion: Successful Treatment of an Acute Flare of Crohn's Colitis During Pregnancy with Unfractionated Heparin. Inflamm Bowel Dis, 8: 192-195, 2002.
58. K Ina, K Kusugami, M Shimada, T Tsuzuki, Y Nishio, DG Binion, A Imada, T Ando: Suppressive Effects of Cyclosporine A on Neutrophils and T cells may be related to therapeutic benefits in patients with steroid-resistant ulcerative colitis. Inflamm Bowel Dis, 8: 1-9, 2002.
59. DG Binion, R Alemzadeh: Growth of an IBD controversy: Growth hormone and high protein diet in adult Crohn’s disease patients. Inflamm Bowel Dis, 7: 176-8, 2001.
60. S Vasilopoulos, K Saiean, J Emmons, WL Berger, M Abu-Hajir, B Seetharam, DG Binion: Terminal ileal resection is associated with elevated plasma homocysteine in Crohn’s disease. J Clin Gastroenterol, 33: 132-136, 2001.
61. UG Strauch, RC Mueller, M Cernadas, J Higgins, DG Binion, CM Parker: Integrin aE (CD103) b7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-Cadherin independent interaction. J Immunol, 166: 3506-3514, 2001.
62. TC Puchner, S Kugathasan, KJ Kelly, DG Binion: Successful desensitization and therapeutic use of Infliximab in adult and pediatric Crohn’s disease patients with prior anaphylactic reaction. Inflamm Bowel Dis, 7: 34-7, 2001.
63. YC Chai, DG Binion, GM Chisolm: Relationship of molecular structure to the mechanism of lysophospholipid induced smooth muscle cell proliferation. Am J Physiol Heart Circ Physiol, 279: H1830-1838, 2000.
64. S Kugathasan, S Werlin, A Martinez, MT Rivera, J Heikenen, DG Binion, “Prolonged duration of response to Infliximab in early pediatric Crohn’s disease.” Am J Gastroenterol, 95: 3189-3194, 2000.
65. DG Binion, P Rafiee, S Fu, KS Ramanujam, MT Rivera, PJ Fisher, CP Johnson, GL Telford, MT Otterson, KT Wilson: Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radic Biol Med, 29: 881-888, 2000.
66. K Ina, J Itoh, K Fukushima, K Kusugami, T Yamaguchi, K Kyokane, A Imada, DG Binion, A Musso, GA West, GM Dobrea, TS McCormick, EG Lapetina, AD Levine, CA Ottaway, A Musso, C Fiocchi: Resistance of Crohn’s disease T cells to multiple apoptotic signals is associated with a bcl-2/Bax mucosal imbalance. J Immunol, 163: 1081-1090, 1999.
67. MS Jaciewicz, DWK Acheson, DG Binion, GA West, LL Lincicome, C Fiocchi, GT Keusch: Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. Infect Immun, 67: 1439-1444, 1999.
68. S Kugathasan, J Willis, BB Dahms, MA O’Riordan, V Hupertz, DG Binion, JT Boyle, C Fiocchi: Intrinsic hyperreactivity of mucosal T-cells to interleukin-2 in pediatric Crohn’s disease. J Pediatr, 133: 675-81, 1998.
69. DG Binion, GA West, EE Volk, JA Drazba, NP Ziats, RE Petras, C Fiocchi: Acquired increased in leukocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet, 352: 1742-46, 1998.
70. DG Binion, S Fu, KS Ramanujam, YC Chai, JA Drazba, NP Ziats, S Erzurum, KT Wilson: iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am J Physiol, 275: G592-G603, 1998.
71. DG Binion, GA West, K Ina, NP Ziats, SE Emancipator, C Fiocchi: Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology, 112: 1895-1907, 1997.
72. RM Soetikno, W Tantibhedhyangkul, DG Binion, Rouse RV: Ménétrier’s disease: Report of a transient case associated with chylous ascites. Am J Gastroenterol, 92: 1364-1367, 1997.
73. DG Binion, C Fiocchi: Current concepts of inflammatory bowel disease pathogenesis. Resident Staff Physician, 40: 11-16, 1994.
74. PG Quinn, DG Binion, P Connors: Inflammatory bowel disease endoscopy. Med Clin N Am, 78: 1331-1352, 1994.
75. C Fiocchi, DG Binion, JA Katz: Cytokine production in the human gastrointestinal tract during inflammation. Curr Opin Gastroenterol, 10: 639-644, 1994.
ABSTRACTS
1. A Ananthakrishnan, E McGinley, DG Binion: Excess hospitalization burden due to Clostridium difficile in patients with Inflammatory Bowel disease. Gastroenterology; 132: A20, 2007.
2. A Naik, LR Weber, JF Knox, J Emmons, S Skaros, M Issa, DG Binion: Longterm methotrexate maintenance immunodulator therapy in ulcerative colitis. Gastroenterology; 132: A185, 2007.
3. A Ananthakrishnan, LR Weber, JF Knox, S Skaros, J Emmons, M Issa, S Lundeen, MF Otterson, DG Binion: Permanent work disability in Crohn's disease. Gastroenterology; 132: A512, 2007.
4. M Arif, LR Weber, JF Knox, S Skaros, J Emmons, M Issa, S Lundeen, MF Otterson, DG Binion: Incidence and risk factors for Thromboembolism in Inflammatory Bowel disease (IBD). Gastroenterology; 132: A513, 2007.
5. M Arif, LR Weber, JF Knox, S Skaros, M Issa, J Emmons, S Lundeen, MF Otterson, DG Binion: Patterns of proton pump inhibitor use in Inflammatory Bowel disease and concomitant risk of Clostridium difficile infection. Gastroenterology; 132: A513, 2007.
6. M Arif, LR Weber, JF Knox, S Skaros, J Emmons, M Issa, S Lundeen, MF Otterson, DG Binion: Clinical Hypertension and vascular complication in Inflammatory Bowel disease. Gastroenterology; 132: A516, 2007.
7. M Issa, LR Weber, Y Kanaa, J Emmons, S Skaros, JF Knox, MR Otterson, DG Binion: Recurrent Clostridium difficile colitis in inflammatory bowel disease patients. Gastroenterology; 132: A660, 2007.
8. M Issa, LR Weber, S Skaros, DB Beaulieu, J Emmons, JF Knox, S Lundeen, MF Otterson, DG Binion: Decreasing rates of colectomy despite high rates of hospitalization in C. difficile infected IBD patients: A tertiary referral center experience. Gastroenterology; 132: A663, 2007.
9. M Arif, LR Weber, JF Knox, S Skaros, M Issa, S Lundeen, MF Otterson, DG Binion: Prevalence and Management of Comorbid Depression in Inflammatory Bowel Disease (IBD). Gastroenterology; 132: A659, 2007.
10. M Rajagopal, LR Weber, M Issa, S Skaros, JF Knox, S Lundeen, MF Otterson, DG Binion: Distinct phenotypes of inflammatory bowel disease in U.S. minority populations: Comparison of African Americans and Asian subgroups. Gastroenterology; 132: A662, 2007.
11. MF Otteson, DG Binion, VM Nelson, W Floer, Y Kanaa, P Rafiee: Induction of Hsp32 by Curcumin rescues Human Intestinal Microvascular Endothelial Cells (HIMEC) from Irradiation Induced apoptosis. Gastroenterology; 132: A570, 2007.
12. P Rafiee, VM Nelson, Y Kanaa, MF Otterson, DG Binion: Curcumin sensitizes Human Intestinal Microvascular Endothelial Cells (HIMEC) to Ionizing Radiation by Targeting mTOR and Akt. Gastroenterology; 132: A367,2007.
13. J Jorns, MF Otterson, DG Binion, H Lim, R Komorowski: Correlation of Histology with Medical Treatment of Crohn’s Disease. Gastroenterology; 132: A877, 2007.
14. DB Beaulieu, M Abu-Hajir, M Issa, J Newcomer, RS Kuhlman, MR Otterson, J Emmons, JF Knox, DG Binion: Treatment of Hospitalized Refractory Crohn’s Colitis Flare during Pregnancy with Low Molecular Weight Heparin: Report of Two Cases. Am J Gastroenterol, 101: S465, 2006
15. S Corman, M Issa, DB Beaulieu, LR Weber, H Brandenburg, J Emmons, JF Knox, S Skaros, D Thameem, DG Binion: Escalation of Infliximab Maintenance Therapy in Crohn’s disease. Am J Gastroenterol, 101: S470, 2006.
16. M Issa, LR Weber, H Brandenburg, J Emmons, S Skaros, JF Knox, DB Beaulieu, DG Binion: Rifaximin and treatment of recurrent Clostridium difficile infection in patients with Inflammatory Bowel disease. Am J Gastroenterol, 101: S469, 2006.
17. M Issa, DB Beaulieu, SV Shidham, LR Weber, DG Binion: Normal acute phase response markers are identified in 13% of hospitalized ulcerative colitis patients admitted with severe flare. Am J Gastroenterol, 101: S461, 2006.
18. DB Beaulieu, LR Weber, M Issa, JR Newcomer, RS Kuhlmann, MF Otterson, J Emmons, JF Knox, DG Binion: Budesonide induction and maintenance therapy for Crohn’s disease during pregnancy. Am J Gastroenterol, 101: S463, 2006.
19. JB Williams, LR Weber, DB Beaulieu, M Issa, JF Knox, J Emmons, MF Otterson, OA Hatoum, DG Binion: Long-term infliximab maintenance infusion regimens and rates of hospitalization, surgery and disability in Crohn’s disease in patients treated beyond two years. Gastroenterology, 130: A143, 2006.
20. OA Hatoum, DG Binion, H Miura, RM Selle, SA Phillips, D Kopelman , DD Gutterman: Role of Thromboxane in Flow-mediated Vasoconstriction in Inflammatory Bowel Disease (IBD). Gastroenterology, 130: A489, 2006.
21. S Horowitz, A Rogaczewski, V Nelson, Z Lazarova, C Andrekopouios, B Kalyanaraman, MF Otterson, DG Binion, P Rafiee: Increased arginase II contributes to decreased NO synthesis in human intestinal microvascular endothelial cells and microvessels in IBD. Gastroenterology, 130: A684, 2006.
22. P Rafiee, S Horowitz, A Rogaczewski, V Nelson, B Kalyanaraman, MF Otterson, DG Binion: Increased human intestinal microvascular endothelial arginase activity mediated by RhoA pathway: Mechanisms underlying IBD endothelial dysfunction. Gastroenterology, 130: A686, 2006.
23. R Ashwathnarayan, LR Weber, M Issa, JF Knox, S Skaros, OA Hatoum, J Emmons, DG Binion: Azathioprine intolerant Crohn’s disease patients: A clinical subgroup with significantly worse disease complications, severity and disability. Gastroenterology, 130: A646, 2006.
24. M Issa, LR Weber, SV Shidham, DB Beaulieu, DG Binion: Infliximab significantly increases proportion of overweight/obese Crohn’s disease patients receiving longterm maintenance therapy. Gastroenterology, 130: A209, 2006.
25. M Issa, S Skaros, DB Beaulieu, LR Weber, AS Vijayapal, MB Graham, JF Knox, J Emmons, OA Hatoum, MF Otterson, DG Binion: Increasing impact of Clostridium difficile on Inflammatory Bowel Disease: A tertiary referral center experience. Gastroenterology, 130: A649, 2006.
26. M Issa, S Skaros, MF Otterson, S Lundeen, LR Weber, DB Beaulieu, JF Knox, DG Binion: Corticosteroid dose influences colectomy rate in hospitalized IBD pts with Clostridium difficile. Gastroenterology, 130: A656, 2006.
27. T Venkatesan, DB Beaulieu, V Ferrer, LR Weber, J Podoll, JF Knox, J Emmons, M Issa, KA King, DG Binion: Abnormal Pap smear, cervical dysplasia and immunomodulator therapy in women with Inflammatory Bowel Disease (IBD). Gastroenterology, 130: A3, 2006.
28. V Ferrer, MF Otterson, S Lundeen, LR Weber, M Issa, S Skaros, JS Bajaj, OA Hatoum, DG Binion: Elevated C-reactive protein on admission predicts colectomy in hospitalized IBD colitics with and without Clostridium difficile co-infection. Gastroenterology, 130: A210, 2006.
29. LR Weber, DB Beaulieu, J Emmons, JF Knox, MF Otterson, M Issa, S Skaros, DG Binion: Successful infliximab re-initiation in a previously allergic Crohn’s Disease patient following hematopoietic stem cell transplantation (HSCT). Gastroenterology, 130: A662, 2006.
30. P Rafiee, AL Rogaczewski, VM Nelson, I Ali, DG Binion, Reza Shaker: Transcriptional regulation of acidic pH induced interleukin-6 expression and secretion in human esophageal epithelial cells (HET-1) via MAPKs. Gastroenterology, 130: A686, 2006.
31. SJ Lundeen, MF Otterson, GLTelford, DG Binion, WJ Peppard: Clostridium difficile enteritis: An early post-operative complication in IBD patients following colectomy. Gastroenterology, 130: A890, 2006.
32. OA Hatoum, H Miura, RM Selle, BT Larsen, D Kopelman, MF Otterson, DD Gutterman, DG Binion: Beneficial effect of mesalamine on microvascular dysfunction in ulcerative colitis. Gastroenterology, 130: A698, 2006.
33. MF Otterson, KR Theriot, DG Binion, D Thameem, S Shidham, OA Hatoum, S Lundeen, GL Telford, Rapid Re-Operation for Crohn's Disease. Gastroenterology, 130: A856, 2006.
34. AL Rogaczewski, PJ Fisher, ME Theriot, VM Nelson, MF Otterson, DG Binion, P Rafiee: Sensitization of Human Intestinal Microvascular Endothelial Cells (HIMEC) to Ionizing Radiation by Curcumin. Gastroenterology, 130: A683, 2006.
35. P Rafiee, M Theriot, MF Otterson, DG Binion: Role of MAPK in activation of Signal Transducers and Activators of Transcription (STATs) Proteins in VEGF stimulated Human Intestinal Microvascular Endothelial Cells (HIMEC). Gastroenterology, 130: A686, 2006.
36. I Ali, P Rafiee, V Nelson, A Rogaczewski, DG Binion, R Shaker: Acidic Media Increases the Expression of Dickkoph Homolog (Dk-1) and 4 (Dkk-4) in Esophageal Epithelia Het-1A Cells. Gastroenterology, 130: A385, 2006.
37. SB Hanauer , EV Loftus , DG Binion, GL Gordon, N Smith-Hall, L Law: Safety of delayed-release oral mesalamine 4.8 g/day (800 mg tablet) compared to 2.4 g/day (400 mg tablet) for treatment of active ulcerative colitis: analysis of combined data from two randomized controlled trials. 2005.
38. J Heidemann, C Ruther, M Kebschull, P Lebiedz, DG Binion, W Domschke, T Kucharzik, C Maaser: Microbial Antigens Stimulate Expression of Epstein-Barr virus induced-gene (EBI-)3 and other IL-12 related Molecules in Human Intestinal Microvascular Endothelial Cells (HIMEC). Gastroenterology, 128(4): A19, 2005.
39. J Heidemann, M Kebschull, P Lebiedz, K Klimmek, DG Binion, W Domschke, C Maaser, T Kucharzik: Human Intestinal Microvascular Endothelial Cells (HIMEC) Reveal Inflammatory Response Gene Expression Patterns Different from Dermal Microvascular Endothelial Cells (HMEC-1). Gastroenterology, 128(4): A212, 2005.
40. G Samuel, JF Knox, MF Otterson, DG Binion: Steroid dependent small bowel Crohn's disease: Correlation with quality of life and radiologic findings. Gastroenterology, 128(4): A328, 2005.
41. AS Vijayapal, MB Graham, BT Massey, JF Knox, J Emmons, JF Collins, OA Hatoum, MF Otterson, GL Telford, DG Binion: Increasing awareness and impact of Clostridium difficile on Inflammatory Bowel disease: A tertiary referral center experience. Gastroenterology, 128(4): A328, 2005.
42. P Rafiee, ME Theriot, MR Otterson, DG Binion: Vascular Endothelial Growth Factor (VEGF) Protects Human Intestinal Microvascular Endothelial Cells (HIMEC) Against Ionizing Radiation Induced Cell Death Via PI3K/Akt, Bcl-2 and MAPKs. Gastroenterology, 128(4): A185, 2005.
43. P Rafiee, H Ogawa, J Heidemann, ME Theriot, CP Johnson, R Shaker, DG Binion: Human Esophageal Microvascular Endothelial Cells (HEMEC) Respond to Acid Stress by p 38 MAP kinase Regulated Induction of HSP70i and HSP27. Gastroenterology, 128(4): A346, 2005.
44. P Rafiee, ME Theriot, MF Otterson, DG Binion: Vascular Endothelial Growth Factor (VEGF) Activates Signal Transducers and Activators of Transcription (STATs) Proteins in Human Intestinal Microvascular Endothelial Cells (HIMEC). Gastroenterology, 128(4): A516, 2005.
45. OA Hatoum, MF Otterson, JC Densmore, H Miura, BT Larsen, DG Binion, DD Gutterman: Acute radiation toxicity induces endothelial dysfunction in intestinal microvessels. Gastroenterology, 128(4): A655, 2005.
46. BT Larsen, PF Pratt, H Miura, DG Binion, DD Gutterman, OA Hatoum: Alterations in expression and activity of cytochrome P450 epoxygenases u-hydroxylases may play a significant role in inflammatory bowel disease. Gastroenterology, 128(4): A213, 2005.
47. S Ramanujam, JF Knox, J Emmons, OA Hatoum, MR Otterson, RK Cross, ME Csuka, DG Binion: Leflunomide treatment of moderate to severe ulcerative colitis patients intolerant to standard immunomodulator therapy. Gastroenterology, 128(4): A585, 2005.
48. S Ramanujam, JF Knox, J Emmons, MR Otterson, RK Cross, ME Csuka, DG Binion: Leflunomide is effective as a steroid sparing, maintenance therapy for moderate to severe Crohn's disease patient intolerant to standard immunomodulator therapy. Gastroenterology, 128(4):A111, 2005.
49. AN Anathakrishnan, T Atilla, JS Bajaj, MF Otterson, R Lipchick, BT Massey, J Maloney, R Komorowski, DG Binion: Severe pulmonary toxicity following azathioprine/6-mercaptopurine initiation for the treatment of inflammatory disease: A case series. Gastroenterology, 128(4): A575, 2005.
50. JB Williams, RK Cross, D Thameen, JF Knox, J Emmons, MR Otterson, DG Binion: Long-term infliximab maintenance infusion regimens and rates of hospitalization, surgery, and disability in Crohn's disease patients. Gastroenterology, 128(4): A589, 2005.
51. DB Beaulieu, MF Otterson, J Newcomer, R Kuhlmann, M Abu-Hajir, J Emmons, JF Knox, RK Cross, DG Binion: IBD pregnancy complications and outcomes in the era of immunomodulator and biologic therapy: A tertiary referral center experience. Gastroenterology, 128(4): A316, 2005.
52. D Thameem, S Kugathasan, OA Hatoum, J Emmons, JF Knox, KR Theriot, S Shidham, JS Bajaj, DG Binion: Accleration of infliximab maintenance therapy in Crohn's disease. Gastroenterology, 128(4): A587, 2005.
53. AC Barboi, K Spinelli, GS Sudakoff, S Kugathasan, RK Cross, Sinai-Samaritan Jaradeh, MF Otterson, JF Knox, J Emmons, H Brandenburg, DG Binion: Autonomic dysfunction in inflammatory bowel disease (IBD) correlates with diminished quality of life, impaired motility and disability. Gastroenterology, 128(4): A316, 2005.
54. A Sanjeevi, RA Komorowski, S Shaker, BT Massey, R Shaker, K Saeian, C O’Loughlin, DG Binion, WJ Hogan: Eosinophilic Esophagitis: Potential Sources for Diagnostic Error in the Histopathologic Detection. Gastroenterology, 128(4): A7, 2005.
55. K Lee, DG Binion, S Kugathasan: Immediate and Long-term Safety of Infliximab in Children with IBD. Gastroenterology, 128(4): A580, 2005.
56. JJ Rowe, RA Komorowski, VO Osipov, JA Parisi, VB Shidham, DG Binion: Maintenance Infliximab and Resolution of Histopathologic Abnormalities in Colonic Crohn's disease. Mondern Pathology, 18(1):117A, 2005
57. JS Bajaj, K Saeian, RR Varma, J Franco, J Knox, J Emmons, J Podoll, DG Binion: Increased Rates of Early Adverse Reaction to Azathioprine in Patients with Crohn's Disease Compared to Autoimmune Hepatitis: A Tertiary Referral Center Experience. Gastroenterology, 126(4): A715, 2004.
58. P Rafiee, OA Hatoum, PA Kirkwood, Jr., DG Binion: Uncoupled ENOS Activity in Chronically Inflamed Human Intestinal Microvascular Endothelial Cells Contributes to Acquired Microvascular Dysfunction in IBD. Gastroenterology, 126(4): A569, 2004.
59. P Rafiee, MF Otterson, NA Johnson, MS Li, GL Telford, D Ota, DG Binion: VEGF Protects Against Antiangiogenic Effect of Ionizing Radiation on Human Colonic Microvascular Endothelial Cells Through COX2 Induction. Gastroenterology, 126(4): A66, 2004.
60. JF Knox, D Rose, J Emmons, J Podoll, K Saeian, T Attila, RK Cross, DG Binion: Colesevelam for the Treatment of Bile Acid-induced Diarrhea in Crohn's Disease Patients Intolerant of Cholestyramine. Gastroenterology, 126(4): A628, 2004.
61. P Rafiee, J Heidemann, H Ogawa, N Johnson, PJ Fisher, MS Li, MF Otterson, CP Johnson, DG Binion: Anti-angiogenic Effect of Cyclosporin A in Human Intestinal Microvascular Endothelial Cells. Gastroenterology, 126(4): A302, 2004.
62. OA Hatoum, DG Binion, H Miura, JJ Bosnjak, MF Otterson, GL Telford, DD Gutterman: Novel role for hydrogen peroxide in Ach-induced dilation of human intestinal microvessels. Gastroenterology, 126(4): A254, 2004.
63. J Heidemann, C Maaser, A Lugering, TW Spahn, KP Zimmer, H Herbst, W Domschke, P Rafiee, DG Binion, T Kucharzik: Novel Expression of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Human Squamous Esophageal Epithelium – Pathophysiological Implications. Gastroenterology, 126(4): A650, 2004.
64. U Mahadevan, S Kane, WJ Sandborn, RD Cohen, K Hanson, JP Terdiman, DG Binion: Intentional Infliximab Use for Maintenance or Acute Crohn's Disease (CD) Flare in Pregnancy. Gastroenterology, 126(4): A629, 2004.
65. P Rafiee, J Heidemann, H Ogawa, NA Johnson, PJ Fisher, MS Li, MF Otterson, CP Johnson, KA Prichard, DG Binion: Cyclosporin A differentially inhibits multiple steps in VEGF induced angiogenesis in human intestinal microvascular endothelial cells through altered intracellular signaling. Accepted to FASEB.
66. J Heidemann, H Ogawa, P Rafiee, C Maaser, W Domschke, DG Binioin, MB Dwinell: Mucosal angiogenesis regulated by human intestinal microvascular endothelial cell expressed CXCR4 and its cogtnate ligand stromal cell-derived factor1. Accepted to FASEB.
67. RK Cross, KT Wilson, DG Binion: High Prevalence of Polypharmacy in Crohn's Disease. Am J Gastroenterol, 98: S247; 2003.
68. OA Hatoum, KS Spinelli, MF Otterson, GL Telford, M Abu-Hajir, DG Binion: Mesenteric Venous Thrombosis In Inflammatory Bowel Disease. Am J Gastroenterol, 98: S261; 2003.
69. T Attila, KA Spinelli, MF Otterson, A Nakeeb, GL Telford, DG Binion: Clinical Characteristics of Total Parenteral Nutrition (TPN) Dependent Crohn's Disease (CD) Patients in the Era of Biologic and Immunomodulator Therapy. Am J Gastroenterol, 98: S248; 2003.
70. RK Cross, KT Wilson, DG Binion: Narcotic Use in Patients with Crohn's Disease. Am J Gastroenterology, 98: S249; 2003.
71. H Ogawa, P Rafiee, P Fisher, N Johnson, J Heidemann, MF Otterson, DG Binion: MAdCAM-1 Expression in Human Intestinal Microvascular Endothelial Cells (HIMEC) is Regulated by the PI3K/Akt and NFkB Pathways. Gastroenterology, 124: A148, 2003.
72. P Rafiee, OA Hatoum, KT Wilson, MF Otterson, DD Gutterman, DG Binion: Physiologic expression of COX2 and PGE2 in human intestinal microvessels and isolated endothelial cells (HIMEC). Gastroenterology, 124: A148, 2003.
73. T Attila, K Saeian, JF Knox, J Emmons, L Calabrese, D Rose, DN Prajapati, S Kugathasan, MF Otterson, DG Binion: Correlation of short inflammatory bowel disease questionnaire (SIBDQ) with clinical status in routine management of Crohn's disease (CD) patients including ostomates. Gastroenterology, 124: A199, 2003.
74. V Kounev, MB Levy, T Attila, K Saeian, S Kugathasan, JF Knox, J Emmons, WJ Hogan, R Shaker, DG Binion: Increased rates of drug allergy in inflammatory bowel disease (IBD) patients compared to irritable bowel syndrome (IBS) patients and normal controls. Gastroenterology, 124: A214, 2003.
75. S Kugathasan, J Heikenen, RH Judd, SL Werlin, C Brown, DG Binion: Defining the natural history of Crohn's disease behavior prospectively: Categorization of newly diagnosed pediatric patients using Vienna classification. Gastroenterology, 124: A217, 2003.
76. T Attila, K Saeian, V Kounev, MB Levy, JF Knox, J Emmons, DN Prajapati, S Kugathasan, DG Binion: Episodic infusion schedule and azathioprine (Aza) intolerance correlate with the development of severe adverse reaction during infliximab (Inflix) retreatment for Crohn's disease (Cd). Gastroenterology, 124: A526, 2003.
77. S Kugathasan, K-h Cheng, N Johnson, H Ogawa, DG Binion: Inactivation of mucosal SMAD signaling is associated with the progression from early to late Crohn's disease (CD). Gastroenterology, 124: A313, 2003.
78. S Kugathasan, N Collins, K Maresso, A Matter, K Sherry, C Rudolph, DG Binion, U Broeckel: NOD2/CARD15 mutations and phenotypic correlation in pediatric Crohn's disease (CD). Gastroenterology, 124: A375, 2003.
79. OA Hatoum, DG Binion, MF Otterson, DD Gutterman: Acquired microvascular dysfunction in inflammatory bowel disease (IBD): Loss of nitric oxide mediated vasodilation. Gastroenterology, 124: A329, 2003.
80. H Ogawa, J Heideman, P Rafiee, TH Lamirand, PJ Fisher, MF Otterson, GL Telford, K Fukushima, W Domschke, DG Binion: Endotoxin tolerance and toll like receptor (TLR) expression in human intestinal microvascular endothelial cells (HIMEC). Gastroenterology, 124: A338, 2003.
81. NA Johnson, MB Dwinell, V Tolia, DG Binion, S Kugathasan: Expression of CXCR3, CXCR4, CCR5 in early and late pediatric Crohn's disease intestinal mucosal T-lymphocytes. Gastroenterology, 124: A323, 2003.
82. P Rafiee, H Ogawa, J Heidemann, PJ Fisher, NA Johnson, CP Johnson, R Shaker, DG Binion: Mechanisms of human esophageal microvascular endothelial activation in response to inflammatory cytokines and acid: Role of MAPK and NFkB. Gastroenterology, 124: A455, 2003.
83. J Heidemann, H Ogawa, P Rafiee, C Maaser, HR Gockel, W Domschke, DG Binion, MB Dwinell: Human intestinal microvascular endothelial cells express CXCR4 and its sole ligand stromal cell-derived factor-1: Regulation of human intestinal mucosal angiogenesis. Gastroenterology, 124: A596, 2003.
84. C maser, J Heidemann, T Kucharzik, TW Spahn, C Von Eiff, DG Binion, W Domschke, N Luegering: Human Intestinal Microvascular Endothelial Cells (HIMEC) Express Toll-Like Receptor 5 – a Potential Binding for Bacterial Flagella. Gastroenterology, 124: A498, 2003.
85. J Heidemann, H Ogawa, P Rafiee, C Maaser, W Doschke, DG Binion: Mucosal angiogenesis regulated by human intestinal microvascular endothelial cell expressed CXCR4 and its cognate ligand stromal cell-derived factor-1. FASEB J, 17(5): A802.
86. GS Tay, DG Binion, MF Otterson: Multivariant analysis suggests that peri-operative Crohn's disease intra-abdominal septic complications are decreased by concomitant immunomodulator therapy. Accepted to Central Surgical Association 60th Annual Meeting, March 20-22, 2003, Toronto, Canada.
87. S Gawrieh, DN Prajapati, K Saeian, RR Varma, J Franco, JF Knox, M Kern, DG Binion: Prevalence and patterns of liver function test abnormalities in patients with inflammatory bowel disease. Accepted to AASLD American Association on Study of Liver Disease Annual Meeting: Boston, MA; 2002.
88. T Attila, DN Prajapati, MF Otterson, DG Binion: Azathioprine associated pulmonary nodules in a patient with Crohn's disease. Am J Gastroenterol, 97:S226; 2002.
89. GS Tay, MF Otterson, DG Bini