Radiation Oncology

John E. Moulder, PhD Professor and Director of Radiation Biology Department of Radiation Oncology 8701 Watertown Plank Road Milwaukee, WI 53226  (414) 456-4670 (secretary) jmoulder@mcw.edu

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Research Interests

• The biological basis for carcinogenesis and cancer therapy
• Prevention and treatment of radiation-induced normal tissue injury
• The impact of tumor hypoxia on radiotherapy
• Biological aspects of human exposure to non-ionizing radiation
• Radiological terrorism countermeasures
• Radiobiological risks of space travel

Dr Moulder  has published extensively in these areas, and his research has been supported by the National Institutes of Health and the American Cancer Society.

Dr Moulder has lectured on ionizing and non-ionizing radiation biology and human health to biologists, physicists, physicians, policy makers and industry groups around the world; and has served as a consultant and expert witness in several cases involving the alleged health effects of exposure to ionizing and non-ionizing radiation. He also maintains the Electromagnetic Fields and Human Health site on the Internet.

Dr Moulder is a member of the National Council on Radiation Protection, the Radiation Research Society, the Environmental Mutagen Society, the Bioelectromagnetics Society, and the IEEE. He is Senior Editor of Radiation Research and an Associate Editor of Experimental Biology and Medicine. He has served on a number of national and local advisory groups concerned with environmental health, non-ionizing radiation, uses of radiation in medicine, and radiological terrorism countermeasures.

Education

• PhD Cell Biology Yale University, New Haven, CT (1972).
• M Phil Cell Biology Yale University, New Haven, CT (1969).
• BA Biology and Chemistry Carleton College, Northfield, MN (1967).

Training

• Post-doctoral Fellowship Radiation Oncology, Yale University, New Haven, CT (1973-1975).

Representative Publications

• JE Moulder, S Rockwell: Hypoxic fractions of solid tumors: experimental techniques, methods of analysis, and a survey of existing data. Int J Radiat Oncol Biol Phys 10: 695-712, 1984.
• JE Moulder, J Dutreix, S Rockwell, DW Siemann: Applicability of animal tumor data to cancer therapy in humans. Int J Radiat Oncol Biol Phys 14:913-927, 1988.
• LE Kun, JE Moulder: General principles of radiation therapy. In: PA Pizzo, DG Poplack (Ed): Principles and Practice of Pediatric Oncology, 2nd Edition, JB Lippincott, Philadelphia, 1992, pp 273-302.
• B Erickson, MF Otterson, SK Sarna, JE Moulder: Altered motility causes the early gastrointestinal toxicity of irradiation. Int J Radiat Oncol Biol Phys 28:905-912, 1994.
• EP Cohen, BL Fish, JE Moulder: The role of nitric oxide in radiation nephropathy. Arch Physiol Biochem. 104:200-206, 1996.
• MF Otterson, SK Sarna, JE Moulder: The effects of radiation on gastrointestinal motility and potential therapies. In: TJ MacVittie, JF Weiss, D Browne (eds): Advances in the Treatment of Radiation Injuries. Elsevier, New York, 1996, pp. 207-216.
• KR Foster, LS Erdreich, JE Moulder: Weak electromagnetic fields and cancer in the context of risk assessment. Proc IEEE, 85:733-746, 1997.
• CA Lawton. EP Cohen, KJ Murray, SW Derus, JE Moulder: Long-term results of selective renal shielding in patients undergoing total body irradiation in preparation for bone marrow transplantation. Bone Marrow Transplant 12:1069-1074, 1997.
• JE Moulder, BL Fish, EP Cohen: Radiation nephropathy is treatable with an angiotensin converting enzyme inhibitor or an angiotensin II type-1 (AT1) receptor antagonist. Radiother Oncol 46:307-315, 1998.
• JE Moulder, LS Erdreich, RS Malyapa, J Merritt, WF Pickard, Vijayalaxmi: Cell phones and cancer: What is the evidence for a connection? Radiat. Res. 151:513-531, 1999.
• A Molteni, JE Moulder, EP Cohen, WF Ward, BL Fish, J. Taylor, L Wolfe, L Brizio-Molteni, P Veno: Control of radiation-induced pneumopathy and lung fibrosis by angiotensin converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int. J. Radiat. Biol. 76:523-532, 2000.
• JE Moulder: Multi-organ problems associated with total or partial body irradiation. The Medical Basis for Radiation Accident Preparedness: Clinical Care of Victims, edited by RC Ricks, ME Berger, F O'Hara. Parthenon Publishing Group, New York, 2002, pp. 175-189.
• JE Moulder: Pharmacological intervention to prevent or ameliorate chronic radiation injuries. Seminars Rad Oncol 13:73-84, 2003.
• HA al-Hallaq, MA Zamora, BL Fish, HJ Halpern, JE Moulder, GS Karczmar: Using high spectral and spatial resolution BOLD MRI to choose the optimal oxygenating treatment for individual cancer patients. Adv Exp Med Biol 230:433-440, 2003.
• JE Moulder: Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents. Int J Rad Biol 80:2-10, 2004.
• JE Moulder, BL Fish, EP Cohen: The impact of angiotensin II type-2 receptor blockade in experimental radiation nephropathy. Radiat Res 161:312-317, 2004.
  
• JE Moulder, KR Foster, LS Erdreich, JP McNamee:  Mobile phones, mobile phone base stations, and cancer; A review. Int J Rad Biol 81:189-203, 2005.
  
• JE Moulder, EP Cohen: Radiation-induced multi-organ involvement and failure:  The contribution of radiation effects on the renal system. Brit J Radiol Supplement 27:82-88, 2005.
• M Sharma, ET McCarthy, R Sharma, BL Fish, VL Savin, EP Cohen, JE Moulder: Arachidonic acid metabolites mediate the radiation-induced increase in glomerular albumin permeability. Exper Biol Med 231:99-109, 2006.
• OA Hatoum, MF Otterson, D Kopleman, H Miura, I Sukhotnik, BT Larsen, RM Selle, JE Moulder, DD Gutterman: Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. Arterioscler Thromb Vasc Biol 26: 287-294, 2006.
• A Molteni, S Heffelfinger, JE Moulder, BD Uhal, WJ Castellani: Potential deployment of angiotensin converting enzyme inhibitors and of angiotensin 2 type 1 and type 2 receptor blockers in cancer chemotherapy. Anti-Cancer Agents Med Chem 6:451-460, 2006.
• S Rockwell, BF Kimler, JE Moulder: Publishing negative results: the problem of publication bias (Editorial). Radiat Res 165:623-625, 2006.
• JE Moulder, EP Cohen: Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Rad Oncol 17(2):141-148, 2007.
• JE Moulder, BL Fish, EP Cohen: Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists. Current Pharm Design 13:1317-1325, 2007.
• A Molteni, LF Wolfe, WF Ward, CH Ts’ao, LB Molteni, P Veno, BL Fish, JM Taylor, N Quintalilla and JE Moulder: Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-b (TGF‑b) and alpha smooth muscle actin (a-SMA). Current Pharm Design 13:1295-1298, 2007.
• EP Cohen, BL Fish, M Sharma, XA Li, JE Moulder: The role of the angiotensin II type-2 (AT2) receptor in radiation nephropathy. Trans Res 150:106-115, 2007.
• JE Moulder, EP Cohen: Renal dysfunction after total body irradiation: dose-effect relationship: In regard Kal and Van Kempen-Harteveld (Int J Radiat Oncol Biol Phys 2006;65:1228-1232). Int J Radiat Oncol Biol Phys 67:319, 2007.
• EP Cohen, WR Drobyski, JE Moulder: Significant increase in end-stage renal disease after hematopoietic cell transplantation. Bone Marrow Transplant 39:571-572, 2007.
• EP Cohen, MM Joines, JE Moulder: Prevention and treatment of radiation injuries – The role of the renin-angiotensin system. In Late Effects on Normal Tissues of Cancer Treatment (P Rubin, LS Constine, LB Mark, P Okunieff, eds.), Springer-Verlag, Heidelberg. (In Press)
• EP Cohen, AA Irving, WR Drobyski, JP Kline, J Passweg, JM Talano, MB Juckett, JE Moulder: Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Rad Oncol Biol Phys (in press).

Meeting Presentations

• AA Irving, JE Moulder, EP Cohen: Clinical trial of captopril versus placebo to prevent BMT nephropathy. 53rd Annual Radiat Res Soc, 2006.
• JE Baker, R Migrino, J Strande, BL Fish, JE Moulder: Radiation exposure associated with radiological terrorism increases risk factors for cardiovascular disease. 53rd Annual Radiat Res Soc, 2006.
• M Sharma, R Sharma, ET McCarthy, VJ Savin, BL Fish, EP Cohen, JE Moulder: Total body irradiation changes urinary protein profile. 53rd Annual Radiat Res Soc, 2006.
• C Driscoll, AA Irving, BL Fish, JE Moulder, M Lenarczyk: Biomarkers of chronic oxidative damage after TBI. 53rd Annual Radiat Res Soc, 2006.
• JE Moulder, BL Fish, EP Cohen: Renin-angiotensin system suppression as a radiological terrorism countermeasure. 53rd Annual Radiat Res Soc, 2006.
• M Sharma M, BT Wakim, BD Halligan, VH Gattone, BL Fish, VJ Savin, EP Cohen, JE Moulder: Identification of early biomarkers of radiation injury using the urine proteome. Amer Soc Nephrol, 2006.
• SN Ghosh, ML Mäder, JE Moulder, ER Jacobs, T Lowry, M Medhora: Radiation-induced injury localized to the rat lung: changes in pulmonary function. 13th International Congress of Radiation Research, San Francisco, 2007.
• M Lenarczyk, M Sharma, BL Fish, MA Crosby, JE Moulder: Does Total Body Irradiation Result in Chronic Oxidative Stress in Normal Kidney? 13th International Congress of Radiation Research, San Francisco, 2007.
• JE Moulder, BL Fish, AA Irving, M Mäder, EP Cohen: Exploring mechanisms for the efficacy of ACE inhibitors and AII blockers in radiation nephropathy. 13th International Congress of Radiation Research, San Francisco, 2007.
• R Zhang, Y Gao, SN Ghosh, JE Moulder, BL Fish, ER Jacobs, M Medhora: Radiation–induced changes in vasoconstriction of rat pulmonary arteries to angiotensin II are mitigated by captopril. 13th International Congress of Radiation Research, San Francisco, 2007.
• Otterson MF, S Leming, J Callison, J Moulder, P Raifee: ACE inhibition immediately following irradiation may increase GI morbidity and mortality. 13th International Congress of Radiation Research, San Francisco, 2007.
• Q Wu, JE Moulder, M Medhora, R Molthen: Pulmonary vascular injury resulting from a single exposure to low-dose thoracic radiation. 8th World Congress of Microcirculation, Milwaukee, 2007. 

Invited Presentations

• "Mitigation and Treatment of Radiation Injuries via Antagonism of the Renin-angiotensin System”, Henry Ford Hospital, Detroit, 2006.
• “Post-Irradiation Intervention to Mitigate and Treat Radiation-Induced Renal Injuries”, Centers for Medical Countermeasures against Radiation (CMCR) Annual Meeting, Gaithersburg, 2006.
• “Captopril for Mitigation and Treatment of Radiation-Induced Chronic Renal Injuries”, NIAID/CMCR Workshop on the FDA Pre-Market Regulatory Process: Applications to Radiation Countermeasures After a Large-Scale, Radiological Incident, Gaithersburg, 2006.
• “Non-Cancer Late Effects”, NASA Radiation Medical Countermeasures Workshop, Johnson Space Center, Houston, 2006.
• “Radiation Injury from Accidents or Terrorism”, Multidisciplinary Pediatric Trauma Rounds, Childrens’ Hospital of Wisconsin, Milwaukee, 2007.
• “Mitigation and treatment of radiation-induced renal injury in bone marrow transplant survivors”, Conference on Normal Tissue Radiation Effects, Nevada Cancer Institute, Las Vegas, 2007.