Radiation Oncology

X. Allen Li, PhD, DABMP, FAAPM Chief of Physics and Professor Department of Radiation Oncology 8701 Watertown Plank Road Milwaukee, WI 53226 (414) 805-4362 phone (414) 805-4354 fax ali@mcw.edu

Curriculum Vitae

Research Interests

• Biological modeling for radiation treatment planning
• Anatomical/biological/functional imaging guided radiotherapy planning and delivery
• Monte Carlo application to radiotherapy dosimetry

Education

• PhD, Electron Paramagnetic Resonance, Department of Physics, Concordia University, Montreal, Quebec, Canada (1989-1992).
• MS, Electron Optics and Electron Microscopy, Department of Physics, Yunnan University, Kunming, China (1983-1986).
• BS, Electron Physics, Department of Physics, Yunnan University, Kunming, China (1979-1983).

Training

• Board Certification, Medical Physics-Radiation Oncology Physics, American Board of Medical Physicts (2001).
• Board Certification, Medical Physics-Radiation Oncology Physics, Canadian College of Physicists in Medicine (1994). 
• Clinical Physics Resident, Ottawa Regional Cancer Centre, Ottawa, Canada (1993-1994).
• Postdoctor, Ionizing Radiation, National Research Council Canada, Ottawa, Canada (1992-1993).

Recent Publications (last 5 years)

• Qi XS, Semenenko VA, Li XA. Improved critical structure sparing with biologically based IMRT optimization.  Med Phys, 36(5):1790-9, 2009.  
• Godley A, Ahunbay E, Peng C, Li XA.  Automated registration of large deformations for adaptive radiation therapy of prostate cancer.  Med Phys, 36(4):1433-41, 2009. 
• Qi ZY, Den XW, Huang SM, Zhang L, He ZC, Li XA, Kwan I, Lerch M, Cutajar D, Metcalfe P, Rosenfeld A.  In vivo verification of superficial dose for head and neck treatments using intensity modulated techniques.  Med Phys, 36(1):2009. 
• Li XA, Tai A, Arthur D, Buchholz T, MacDonald S, Marks L, Pierce L, Taghian A, Vicini F, Woodward W, White J.  Variability of target and normal structure delineation for breast-cancer radiotherapy: a RTOG multi-institutional and multi-observer study. Int J Radiat Oncol Biol Phys, 73(3):944-51, 2009.
• Tai A, Erickson B, Li XA, Extrapolation of normal tissue complication probability for different fractionations in liver irradiation Int J Radiat Oncol Biol Phys, 74(1):283-9, 2009.
• Kainz K, White J, Herman J, Li XA, Investigation of helical tomotherapy for partial-breast irradiation of prone-positioned patients. Int J Radiat Oncol Biol Phys, 74(1):275-82, 2009.
• Semenenko VA, Reitz B, Day E. Qi XS, Miften M, Li XA.  Evaluation of a commercial biologically based IMRT treatment planning system.  Med Phys, 35(12):5851-60, 2008. 
• Li XA, Wang JZ, Stewart RJ, DiBiase SJ, Wang D, Lawton C.  Designing equivalent treatment regimens for prostate radiotherapy using equivalent uniform dose. Br. J. Radiol. 81, 59-68, 2008.
• Das IJ, Cheng CW, Ahnesjö A, Gibbons J, LI XA, Lowenstein J, Mitra RK, Simon WE, Watts RJ. Zhu TC.  Report of AAPM Radiation Therapy Committee Task Group 106: Accelerator beam data commissioning equipment and procedures. Med. Phys. 35, 4186-4215, 2008.
• Tai A, Erickson B, Khater K, Li X.A. Estimate of radiobiological parameters from clinical data for biologically based treatment planning for liver irradiation. Int J Radiat Oncol Biol Phys, 70, 900-907, 2008.
• Wang JZ, Rhee JG, Shi P, Stewart RD, Li X.A.  In vitro Determination Radiation Sensitivity Parameters for DU-145 Prostate Cancer Cells. Int. J. Radiat. Biol., 84, 515–522, 2008.
• Semenenko VA, Li XA. Lyman NTCP model parameters for radiation pneumonitis and xerostomia based on combined analysis of published clinical data. Phys. Med. Biol., 53, 737-755, 2008.
• Semenenko VA, Molthen RC, Li C, Morrow NV, Li R, Ghosh SN, Medhora MM, Li XA.  Irradiation of varying volumes of rat lung to same mean lung dose: A little to a lot or a lot to a little? Int J Radiat Oncol Biol Phys. 71, 838-47, 2008.
• Hsiao Y, Stewart RD, Li, XA. A Monte-Carlo derived dual-source model for helical Tomotherapy treatment planning. Tech. Can. Res. & Tr. 7, 141, 2008.
• Chen G, Ahunbay E, Li XA. Automated computer optimization for 3D treatment planning of breast irradiation. Med. Phys. 35, 2253-58, 2008.
• Zhao L, Sandison G, Farr J, His W, Li XA. Dosimetric evaluation of MIP-based patient aperture and compensator designs to treat lung cancer using proton therapy under free breathing conditions. Phys. Med. Biol. 53, 3343-3364, 2008.
• Ahunbay E, Chen G, Peng C, Yu C, Narayanan S, Lawton C. Li XA, An on-line adaptive planning strategy for inter-fraction image guidance. Med. Phys. 35, 3607-3615, 2008.
• Yang Q, Feng Y, Schultz CJ, Li XA, Wu H, Wang D. Synergistic effect of 15-lipoxygenase 2 and radiation in killing head-and-neck cancer. Cancer Gene Ther. 15, 323-30, 2008.
• Semenenko VA, Reitz B, Day E, Qi XS, Miften M, Li XA.  Evaluation of a Commercial Biologically Based IMRT Treatment Planning System, Med. Phys, 35, 5851-5860, 2008.
• Peng C. Kainz K, Lawton C, Li X.A. A comparison of daily megavoltage ct and ultrasound image guided radiation therapy for prostate cancer. Med. Phys. 35, 5619-5628 2008.
• Qi, XS, Schultz, CJ, Li, XA.  Possible fractionation regimens for treatment of large size arteriovenous malformation using IG-IMRT. Phys. Med. Biol. 52, 5667-5682, 2007.
• Chen, GP, Ahunbay E, Schultz CJ, Li, XA. Development of an inverse optimization package to plan non-uniform dose distributions based on spatially inhomogeneous radiosensitivity extracted from biological images, Med. Phys. 34, 1198-1405, 2007.
• Ahunbay E, Chen GP, Jursinic,P, White J, Thatcher S, Albano K, Li XA. Direct aperture optimization based IMRT for whole breast irradiation.  Int J Radiat Oncol Biol Phys, 67, 1248-1258, 2007.
• Morrow, N.V., Stepaniak, C., White, J., Wilson, J.F., LI, X.A.:  Inter- and intra-fractional uncertainties for prone breast irradiation.  Int J Radiat Oncol Biol Phys, 69, 910-917, 2007.
• Li XA, Hendee RW.  Radiation Oncology physicists will need to better understand medical imaging. J. Am Coll Radiol, 4, 40-44, 2007.
• Li, XA, Qi,XS, Pitterle M, Kalakota K, Mueller K, Jursinic PA, Erickson BA, Wang D, Schultz CJ,  Firat SY, Wilson, JF:  Inter-fractional variations in patient setup and anatomic change assessed by daily CT from helical tomotherapy.  Int J Radiat Oncol Biol Phys, 68, 581-591, 2007.
• Bovi J, Qi SX, White J, Li XA. Comparison of three partial breast irradiation techniques: treatment effectiveness based upon biological models. Radiother. & Oncol, 84, 226-232, 2007.
• Ahunbay E, Li XA. Investigation of the reliability, accuracy and efficiency of gated IMRT delivery with a commercial linear accelerator. Med. Phys, 34, 2928-2938, 2007.
• Cohen EP, Fish BL, Sharma M, Li XA, Moulder JE.  Angiotensin II blockade in radiation nephropathy: the role of the AT₂ receptor.  Translational Research, 150, 106-115, 2007.
• Stewart RD, Li XA. BGRT: Biologically Guided Radiation Therapy – the future is fast approaching! Med. Phys. 34, 3739-3751, 2007 (invited)
• Li XA, Keall P.  Respiratory gating for radiation therapy is not ready for prime time, Med. Phys. 34 867-870, (2007).
• Li XA, Stepaniak C, Gore E.  Technical and dosimetric aspects of respiratory gating using a pressure-sensor motion tracking system. Med. Phys. 33, 145-154, 2006.
• Guerrero M. Li XA.  Halftime for repair of sublethal damage in normal bladder and rectum: an analysis of clinical data from cervix brachytherapy. Phys. Med. Biol, 51, 4063-4071, 2006.
• Qi XR, Schultz CJ, Li XA.  An estimation of radiobiological parameters from clinical outcomes for radiation treatment planning of brain tumors. Int J Radiat Oncol Biol Phys, 64, 1570-1580, 2006.
• Wang JZ, Li XA, Mayr NA.  Dose escalation to combat hypoxia in prostate cancer, a radiobiological analysis of clinical data. Br. J. Radiol, 79, 905-911, 2006.
• Wang D, Schultz CJ, Jursinic PA, Bialkowski M, Zhu R, Brown WD, Rand SD, Campbell BH, Wong S, Li XA, Wilson JF.  FDG-PET/CT guided intensity modulated radiation treatment for head and neck carcinoma.  Int J Radiat Oncol Biol Phys, 65, 143-151, 2006.