Pharmacology and Toxicology

Pharmacology and Toxicology

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Lawan Siangjong

Graduate Student
Department of Pharmacology and Toxicology

B.S., Srinakharinwirot University, THAILAND

Faculty Advisor: Dr. William B. Campbell
Email: lsiangjo@mcw.edu
Phone: (414) 955-8792

 

Research Interest

Arachidonic acid metabolites have been implicated in endothelium-dependent relaxation of many vascular beds. Arachidonic acid is metabolized by endothelial cytochrome P450 epoxygenase, lipoxygenase or cycloxygenase to eicosanoids that regulate vascular tone as well as other biological functions. In mouse arteries, endothelial cell lipoxygenase prooducts of arachidonic acid function as vasodilators and mediate prostaglandin and nitric oxide-independent relaxations. The major products from lipoxygenase pathway are 11,12,15-trihydroxyeicosatetraenoic acid, 15-hydroxy-11,12-epoxyeicosatrienoic acid, 12-hydroxyeicosatetraenoic acid and 15-hydroxyeicosatetraenoic acid. We are investigating the roles of these lipoxygenase metabolites in the mouse vasculature to better understand cardiovascular function and develop potential therapeutics for the treatment of cardiovascular diseases
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