Neurology

Jane A. Madden, Ph.D.

Professor of Neurology
Vice-Chair for Research

Specialty: Adult Neurology

Sub-Specialty:

• Cerebrovascular Circulation

Education:

• B.S., Biology, Marquette University, Milwaukee, WI, 1967
• Ph.D., Electrical Engineering, Biomedical Option, Marquette University, Milwaukee, WI, 1973

Training:

• USPHS Predoctoral Fellow in Biomedical Engineering, Marquette University, Milwaukee WI, 1970-1973
• USPHS-NHLBI Postdoctoral Fellow in Biomedical Engineering, Marquette University, Milwaukee WI, 1976-1979

Societies:

• American Physiology Society
• American Heart Association Circulation Council
• Biomedical Engineering Society
• Wisconsin Association for Biomedical Research and Education

Awards/Honors:

• Phi Sigma  National Biology Honor Society, 1967
• Sigma Xi  National Scientific Honor Society, 1973
• Research Award, American Heart Association, 1988
• Research Award, American Heart Association, 1989
• Superior Performance Award, VAMC, 1990

Brief Clinical/Research Interest Statement:

• Cellular mechanisms of hypoxic pulmonary vasoconstriction
• Physiological and electrical properties of cerebral arteries

PUBLICATIONS

Original Articles:

1. Albarwani, S., Nemetz, L.T., Madden, J.A.., Tobin, A.A., England, S.K., Pratt, P.F., and Rusch, N.J.. Voltage-gated K+ Channels in rat small cerebral arteries: molecular identity of the functional channels . J Physiol 551: 751-763, 2003.
2. Pesic, A., Madden, J.A., Pesic, M and Rusch, NJ. High blood pressure upregulates arterial L-type Ca2+ channels: Is membrane depolarization the signal? Circ. Res. 94: e97-e104, 2004.
3. Olson, K.R., Dombkowski , R.A., Russell, M.J., Doellman, M.M. Head, S.K., Whitfield, N.L. and Madden, J.A. Hydrogen sulfide as an oxygen sensor/transducer in vertebrate hypoxic vasoconstriction and hypoxic vasodilation. J Exp Biol 209: 4011-4023, 2006.
4. Fike, C.D., Kaplowitz, M.R., Zhang, Y. and Madden, J.A. Voltage-gated K+ channels at an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Am J Physiol Lung Cell Mol Physiol 291: 1169-1176, 2006.

Books, Chapters and Reviews:

1. MADDEN, J.A. and Schreiber, M.D. Vascular effects and mechanisms of cocaine and metabolites in the cerebral circulation, In: Prenatal cocaine exposures. (R. J. Konkol and G.D. Olsen , eds) CRC Press (pp 75-93), 1996.
2. MADDEN, J.A. and Rusch, N.J. Electrical properties of vascular smooth muscle. In: Heart Physiology and Pathophysiology, fourth edition, (N. Sperelakis, Y. Kurachi, A. Terzic,. and M. Cohen, eds), San Diego, CA, Academic Press (pp 213-227), 2000.