Radiation Oncology

John E. Moulder, PhD Professor and Director of Radiation Biology Department of Radiation Oncology 8701 Watertown Plank Road Milwaukee, WI 53226 (414) 456-4670 jmoulder@mcw.edu

Curriculum Vitae

Research Interests

• The biological basis for carcinogenesis and cancer therapy
• Prevention and treatment of radiation-induced normal tissue injury
• The impact of tumor hypoxia on radiotherapy
• Biological aspects of human exposure to non-ionizing radiation
• Radiological terrorism countermeasures
• Radiobiological risks of space travel

Dr Moulder has published extensively in these areas, and his research has been supported by the National Institutes of Health and the American Cancer Society.

Dr Moulder has lectured on ionizing and non-ionizing radiation biology and human health to biologists, physicists, physicians, policy makers and industry groups around the world; and has served as a consultant and expert witness in several cases involving the alleged health effects of exposure to ionizing and non-ionizing radiation. He also maintains the Electromagnetic Fields and Human Health site on the Internet.

Dr Moulder is a member of the National Council on Radiation Protection, the Radiation Research Society, the Environmental Mutagen Society, the Bioelectromagnetics Society, and the IEEE. He is Senior Editor of Radiation Research and an Associate Editor of Experimental Biology and Medicine. He has served on a number of national and local advisory groups concerned with environmental health, non-ionizing radiation, uses of radiation in medicine, and radiological terrorism countermeasures.

Education

• PhD, Cell Biology, Yale University, New Haven, CT (1972).
• M Phil, Cell Biology, Yale University, New Haven, CT (1969).
• BA, Biology and Chemistry, Carleton College, Northfield, MN (1967).

Training

• Post-doctoral Fellowship Radiation Oncology, Yale University, New Haven, CT (1973-1975).

Representative Publications (last 5 years)

• Cohen EP, Fish BL, Irving AA, Rajapurkar MM, Shah SV, Moulder JE.  Radiation Nephropathy is not mitigated by antagonists of oxidative stress.  Radiat Res 172:260-264, 2009. 
• Ghosh N, Wu Q, Mader M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC.  Vascular injury folllowing whole thoracic X-ray irradiation in the rat.  Int J Rad Oncol Biol Phys, 74(1):192-199, 2009. 
• Sieber F, Muir SA, Cohen EP, North PE, Fish BL, Irving AA, Mader M, Moulder JE.  High-dose selenium for the mitigation of radiation injury: A pilot study of a rat model.  Radiat Res 171:368-373, 2009. 
• Lenarczyk M, Cohen EP, Fish BL, Irving AA, Sharma M, Driscoll CD, Moulder JE. Chronic oxidateive stress as a mechanism for radiation nephropathy.  Radiat Res 171:164-172, 2009.   
• Sharma M. Halligan BD, Wakin BT, Savin VJ, Cohen EP, Moulder JE.  The urine proteome as a biomarker of radiation injury.  Proteomics Clin Applic 2:1065-1086, 2008. 
• Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M. Structural and functional alteration in the rat lung folowing whole thoracic irradiation with moderate doses: Injury and recovery. Int J Rad Oncol Biol Phys, 84:487-497, 2008. 
• Cohen EP, Joines MM, Moulder JE.  Prevention and treatment of radiation injuries – The role of the renin-angiotensin system. In Late Effects on Normal Tissues of Cancer Treatment (P Rubin, LS Constine, LB Mark, P Okunieff, eds.), Springer-Verlag, Heidelberg, pp69-76, 2008.  
• Cohen EP, Irving AA, Drobyski WR, Kline JP, Passweg J, Talano JM, Juckett MB, Moulder JE.  Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Rad Oncol Biol Phys, 70:1546-1551, 2008. 
• Moulder JE, Cohen EP.  Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Rad Oncol 17(2):141-148, 2007.
• Moulder JE, Fish BL, Cohen EP.  Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists. Current Pharm Design 13:1317-1325, 2007.
• Molteni A, Wolfe LF , Ward WF, Ts’ao CH, Molteni LB, Veno P, Fish BL, Taylor JM, Quintalilla N, Moulder JE.  Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-b (TGF‑b) and alpha smooth muscle actin (a-SMA). Current Pharm Design 13:1295-1298, 2007.
• Cohen EP, Fish BL, Sharma M, Li XA, Moulder JE.   The role of the angiotensin II type-2 (AT2) receptor in radiation nephropathy. Trans Res 150:106-115, 2007.
• Moulder JE, Cohen EP.  Renal dysfunction after total body irradiation: dose-effect relationship: In regard Kal and Van Kempen-Harteveld (Int J Radiat Oncol Biol Phys 2006;65:1228-1232). Int J Radiat Oncol Biol Phys 67:319, 2007.
• Cohen EP, Drobyski WR, Moulder JE.  Significant increase in end-stage renal disease after hematopoietic cell transplantation. Bone Marrow Transplant 39:571-572, 2007.
• Sharma M, McCarthy ET, Sharma R, Fish BL, Savin VL, Cohen EP, Moulder JE.  Arachidonic acid metabolites mediate the radiation-induced increase in glomerular albumin permeability. Exper Biol Med 231:99-109, 2006.
• Rockwell S, Kimler BF, Moulder JE.  Publishing negative results: the problem of publication bias (Editorial). Radiat Res 165:623-625, 2006.
• Hatoum OA, Otterson MF, Kopleman Miura DH, Sukhotnik I, Larsen BT, Selle RM, Moulder JE, Gutterman DD.  Radiation induces endothelial dysfunction in murine intestinal arterioles via enhanced production of reactive oxygen species. Arterioscler Thromb Vasc Biol 26: 287-294, 2006.
• Molteni A, Heffelfinger S, Moulder JE, Uhal BD, Castellani WJ.  Potential deployment of angiotensin converting enzyme inhibitors and of angiotensin 2 type 1 and type 2 receptor blockers in cancer chemotherapy. Anti-Cancer Agents Med Chem 6:451-460, 2006.
• Moulder JE, Foster KR, Erdreich LS, McNamee JP.  Mobile phones, mobile phone base stations, and cancer; A review. Int J Rad Biol 81:189-203, 2005.
• Moulder JE, Cohen EP.  Radiation-induced multi-organ involvement and failure:  The contribution of radiation effects on the renal system. Brit J Radiol Supplement 27:82-88, 2005.
• Moulder JE.  Post-irradiation approaches to treatment of radiation injuries in the context of radiological terrorism and radiation accidents. Int J Rad Biol 80:2-10, 2004.
• Moulder JE, Fish BL, Cohen EP: The impact of angiotensin II type-2 receptor blockade in experimental radiation nephropathy. Radiat Res 161:312-317, 2004.