The NETT network consists of 17 regional Hubs, each with several community hospital Spokes, a Statistical & Data Management Center (SDMC), and a Clinical Coordinating Center (CCC). Oversight of the network is provided by an NINDS appointed Advisory Group (NAG), the NINDS NETT Scientific Program Director and the NINDS NETT Administrative Program Director. The NINDS will also appoint a Data Safety Monitoring Board (DSMB) that will independently monitor safety and performance of trials conducted in the NETT.