Gastroenterology & Hepatology

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Bidyut K. Medda, PhDBidyut K. Medda, PhD
Associate Professor
Doctor of Philosophy (PhD)
University of Calcutta, Calcutta India, 1988
Senior Research Fellowship
Council of Scientific & Industrial Research, Government of India, 1986-1988
Junior Research Fellowship
Indian Council of Medical Research, Government of India, 1982-1986

 

 

 

PUBLICATIONS

Manuscripts

  1. Medda BK.  Cardiovascular status in relation to socioeconomic conditions of school teachers, students and farmers and to chronobiological rhythms of young men of a rural area of Burdwan District, West Bengal, India.  Social Physiology Field (survey) Studies.  University of Calcutta, 1980.

  2. Medda, BK.  Baroreceptors and hypertension:  Role of spinal cord.  Review Article.  University of Calcutta, 1980.

  3. Koley J, Saha JK, Ghosh TK, Sengupta JN, Medda BK, Koley BN.  The effect of nicotine on the perfused heart of toad (Bufo melanostictus) in situ.  Indian J Physiol & Allied Sci 1983;37:145-150.

  4. Koley BN, Medda BK, Koley J.  Reflex effects of baroreceptors and sympathetic nerve activity following urinary bladder distension in the cat.  Indian J Physiol & Allied Sci 1985;39:27-32.

  5. Koley BN, Medda BK, Koley J.  Neurogenic basis for the rise of blood pressure induced by urinary bladder distension in the cat.  Indian J Physiol & Allied Sci 1985;39:57-62.

  6. Koley BN, Medda BK, Koley J.  Viscero-sympathetic reflexes following distension of urinary bladder in the cat.  IRCS Med Sci (U.K.) 1985;13:987-988.

  7. Medda BK.  Viscerovascular reflexes following distension of urinary bladder in the cat. Ph.D. Thesis, University of Calcutta, 1988.

  8. Koley BN, Pal P, Medda BK, Koley J.  Cardiovascular reflexes in stress: Role of sympathetics.  Brain and psychophysiology of stress.  In:  Sharma KN, Selvamurthy W, Bhattacharya N, eds. Indian Council of Medical Research, New Delhi,  1988;103-114.

  9. Koley J, Medda BK, Koley BN.  Role of baroreceptors on viscerovascular responses induced by urinary bladder distension:  Role of spinal cord vasomotor center.  Advances in Physiological Sciences.  In: Manchanda SK, Selvamurthy W, Mohan Kumar V, eds.  Congress of the Asian and Oceanian Physiological Societies, New Delhi, 1990: 129-133.

  10. Shaker R, Ren J, Medda BK, Lang IM, Cowles V, Jaradeh S.  Identification and characterization of the esophagoglottal closure reflex in a feline model.  Am J Physiol 1994; 266:G147-G153.

  11. Medda BK, Lang IM, Layman R, Hogan WJ, Dodds WJ, Shaker R.  Characterization and quantification of a pharyngo-UES contractile reflex in cat.  Am J Physiol 1994;267:G972-G983.

  12. Medda BK, Koley J, Koley B.  Sympathetic efferent activity in the viscerovascular reflexes induced by urinary bladder distension.  Jpn J Physiol 1995;45:265-277. 

  13. Medda BK, Koley J, Koley BN. Sympathoadrenal activity in the visceral (viscerovascular) reflexes to distension of the urinary bladder.  Jpn J Physiol 1996; 46:83-92.

  14. Medda BK, Lang IM, Dodds WJ, Christl M, Kern MK, Hogan WJ, Shaker R.  Correlation of electrical and contractile activity of the cricopharyngeus muscle in the cat.  Am J Physiol 1997; 273:G470-G479.

  15. Shaker R, Medda BK, Ren J, Jaradeh S, Xie P, Lang IM.  Pharyngoglottal closure reflex:  Identification and characterization in a feline model.   Am J Physiol, 1998;275:G521-G525.

  16. Lang IM, Medda BK, Ren J, Shaker R.  Characterization and mechanisms of the pharyngoesophageal inhibitory reflex.   Am J Physiol, 1998;275:G1127-G1136.

  17. Dua KS, Kozarek R, Kim J, Evans J, Medda BK, Lang IM, Hogan WJ, Shaker R.   Self-expanding metal esophageal stent with anti-reflux mechanism. Gastrointestinal Endoscopy, 2001; 53: 603-613 .

  18. Xie P, Medda BK, Ren J, Mustin E, Shaker R, Koch TR. Choline acetyltransferase activity parallels the pressure gradient in the feline pharyngo-esophageal region.   Autonomic Neuroscience:Basic and Clinical, 2001; 89: 125-127.

  19. Lang IM, Medda BK, Shaker R.  Mechanisms of reflexes induced by esophageal     distension. Am J Physiol, 2001; 281: G 1246 - G 1263.    

  20. Lang IM, Nicole D, Medda BK, Shaker R.  Mechanisms of airway protection during retching, vomiting, and swallowing. Am J Physiol, 2002; 281: G 1246 - G 1263.     

  21. Sengupta JN, Medda BK, Shaker R.  Effect of GABAB Receptor Agonist on Distension-sensitive Pelvic Nerve Afferent Fibers Innervating the Colon of the Rat” Am. J. Physiol, 2002; 283: G1343-G1351.   

  22. Medda BK, Kern M,  Ren J, Xie P, Ulualp S, Lang IM, Shaker R.  Relative contribution of various airway protective mechanisms to prevention of aspiration during swallowing.    Am J Physiol, 2003; 284: G933-G939.

  23. Lang IM, Dean C, Medda BK, Shaker R. Differential activation of medullary vagal nuclei during different phases of swallowing in the cat. Brain Research, 2004; 1014:145-163.

  24. Medda BK, Sengupta JN, Lang IM, Shaker R. Response properties of the brainstem neurons following intra-esophageal acid-pepsin perfusion. Neuroscience, 2005; 135: 1285-1295.

  25. Banerjee B, Medda BK, Lazarova Z, shaker R, Sengupta, JN: Effect of Reflux-Induced inflammation on Transient Receptor Potential Vanilloid One (TRPV1) Expression in Primary

  26. Sensory Neurons Innervating the Esophagus of rats. Neurogastroenterol Motil, 2007; 19:681-691.

  27. Dua KS, Reddy ND, Rao VG, Banerjee R, Medda BK, Lang IM:  Impact of reducing Duodenobiliary reflux on biliary stent patency: an in vitro evaluation and a prospective Randomized clinical trial that used a biliary stent with an antireflux valve.

    Gastrointestinal Endoscopy, 2007; 65: 819-828.
  28. Lang IM, Haworth S, Medda BK, Roerig D, Forster H, Shaker R. Airway responses to

    esophageal acidification.  Am J Physiol:Regulatory, Integrative and Comparative Physiology, 2008; 297: R211-R219.    

 

Abstracts

  1. Koley BN, Medda BK, Koley J.  Viscerovascular reflex associated with distension of urinary bladder:  Role of sympathetics.  Indian J Physiol Pharmacol 1983; 27:34.

  2. Koley BN, Medda BK, Koley J.  Sympathetic activation during bladder distension.  Indian J Physiol Pharmacol 1984; 28:5.

  3. Koley BN, Medda BK, Koley J.  Viscerovascular reflexes following distension of urinary bladder:  Role of sympathetics.  Proc 71st Indian Science Congress, Part III, Sect. XI, 1984:15.

  4. Koley BN, Medda BK, Koley J.  Buffer and splanchnic nerves activity in the rise of blood pressure during urinary bladder distension.  Indian J Physiol Pharmacol 1985; 29:92.

  5. Koley BN, Medda BK, Koley J.  Cardiovascular responses to bladder distension. Proc 72nd Indian Science Congress, Part III, Sect. XI, 1985:39.

  6. Koley BN, Medda BK, Koley J.  Sympatho-adrenergic activity induced by urinary bladder distension in the cat.  Indian J Physiol Pharmacol 1986; 30:107.

  7. Koley BN, Medda BK, Koley J.  Effect of urinary bladder distension on blood pressure in splanchnic bed.  Proc 73rd Indian Science Congress, Part III, Sect. XI, 1986:14.

  8. Koley BN, Medda BK, Koley J.  Involvement of suprarenal glands in the rise of blood pressure during bladder distension.  Proc 74th Indian Science Congress, Part III, Sect. IX, 1987:32.

  9. Koley BN, Pal P, Medda BK, Koley J.  Cardiovascular reflexes in stress.  Role of sympathetics. Proc 2nd Indo-Soviet Symp Brain & Psychophysiology of Stress.  1987:30.

  10. Koley J, Medda BK, Koley BN.  Role of baroreceptor on viscerovascular responses induced by urinary bladder distension: Role of spinal vasomotor center.  Proc 2nd Congress of Asian and Oceanian Physiological Societies.  1990; I-93.

  11. Medda BK, Lang IM, Dodds WJ.  Control of upper esophageal sphincter (UES) tone by lung inflation reflexes Gastroenterology 1990;99:1219.

  12. Koley J, Medda BK, Koley BN.  Viscero-sympathetic reflexes induced by urinary bladder distension in cat.  Blood Vessels 1990; 27:41.

  13. Shaker R, Medda BK, Ren J, Lang I, Jaradeh S, Dodds WJ.  Mechanism of esophagoglottal closure reflexes in a cat model.  J Gastrointest Motility 1991; 3:200.        

  14. Medda BK, Lang IM, Layman RD, Ren J, Dodds WJ.  Characterization of a pharyngo-UES reflex in a cat.  Gastroenterology  1992;102:A483.

  15. Shaker R, Medda BK, Ren J, Lang IM, Dodds WJ, Harrington S, Jaradeh S.  Identification and characterization of the esophagoglottal closure reflex in a feline model. Gastroenterology 1992; 102:A512.

  16. Lang IM, Medda BK, Layman RD, Dodds WJ, Shaker R.  Reflex control of UES tone.  Proc 1st Scientific & Inaugural Meeting of the Dysphagia Research Society, 1992.

  17. Medda BK, Lang IM, Layman RD, Hogan WJ, Dodds WJ, Shaker R.  Quantification of the relationship between electrical and contractile activities of upper esophageal sphincter (UES) of the cat.  Gastroenterology 1993; 104:A551.

  18. Lang IM, Medda BK, Layman RD, Hogan WJ, Shaker R.  Control of upper esophageal sphincter function by the nucleus ambiguus.  Gastroenterology 1994; 106:A529.

  19. Medda BK, Lang IM, Hogan WJ, Shaker R.  Brainstem control of the upper esophageal sphincter,  Gastroenterology  1994;107:1230.

  20. Medda BK, Lang IM, Bonnevier JL, Hogan WJ, Shaker R.  Evidence for bilateral function of cricopharyngeus muscle of the cat.  Gastroenterology 1995; 108:A648.

  21. Ren J, Shaker R, Medda BK, Bonnevier J, Kern M, Dunn B.  Effect of acute esophagitis on the esophagoglottal closure reflex in a feline model.  Gastroenterology 1995; 108:A677.

  22. Shaker R, Mustin E, Medda BK, Bonnevier J, Lang I, Koch TR.  Distribution of cholinergic enzymes in muscles of pharyngoesophageal region in two species.  Gastroenterology 1995; 108:A688.

  23. Lang IM, Medda BK, Hogan WJ, Shaker R.  Brainstem mechanisms controlling the esophago-UES contractile reflex.  J Neurogastroenterol Motility 1995; 7:268.

  24. Medda BK, Lang IM, Bonnevier JL, Hogan WJ, Shaker R.  Feline cricopharyngeus muscle is comprised of two functional segments.  J Neurogastroenterol Motility 1995; 7:274.

  25. Ren J, Medda BK, Xie P, Lang I, Shaker R.  Effect of acute experimental esophagitis on stimulation frequency of UES and glottal reflexes provoked by esophageal distension.  Gastroenterology 1996; 110:A239.

  26. Medda BK,  Ren J, Jaradeh S, Xie P, Shaker R.  Identification and characterization of the pharyngoglottal closure reflex in a feline model.  Gastroenterology 1996; 110:A716.   

  27. Xie P, Shaker R, Ren J, Medda BK, Mustin E, Koch TR.  The pressure gradient within      the feline pharyngo-esophageal region parallels the density of choline acetyltransferase activity.  Gastroenterology 1996; 110:A782.

  28. Lang IM, Medda BK, Xie P, Ren J, Shaker R.  Mechanisms of pharyngoesophageal inhibitory reflex in the cat.  Gastroenterology 1997; 112:A771.

  29. Medda BK, Ren J, Xie P, Kern M, Ulualp S, Lang IM, Shaker R.  Relative contribution of various airway protective mechanisms to prevention of deglutitive aspiration.  Gastroenterology 1997; 112:A787.

  30. Lang IM, Medda BK, Shaker R.  Functional studies of the motor innervation of the upper esophageal sphincter (UES) in the cat.  Gastroenterology 1998; 114:A783.

  31. Lang IM, Medda BK, Shaker R.  Sensory mechanisms of esophageal reflexes.  Gastroenterology 1999; 116(4):A1024.

  32. Dua K, Medda BK, Lang I, Shaker R.  Modified self-expanding metal esophageal stent with anti-reflux mechanism:  In vitro and in vivo evaluation.  Gastrointest Endosc 1999; 49(4): AB102.

  33. Lang IM, Medda BK, Shaker R.  Mechanisms controlling ventilatory cycle fluctuations in UES tone.  Gastroenterology 2000; 118(4): A133.

  34. Staff DM, Gu C, Medda BK, Dana NL, Hogan WJ, Massey BT, Kern MK, Shaker R. A new technique for evaluating lower esophageal sphincter compliance. Gastroenterology 2000; 118(4): A134.

  35. Massey BT, Dana NL, Medda BK, Gu C, Lang IM, Shaker R.   Reduction of reflux events by blockade of gastric mechanoreceptors: A novel endoscopic approach. Gastroenterology 2000; 118(4): A486.

  36. Lang IM, Dean C, Medda BK, Shaker R. Functional mapping of phases of swallowing in vagal complex. Gastroenterology 2000; 118(4): A1184.

  37. Medda BK, Sengupta JN, Lang IM, Shaker R. Characterization of neurons in the Brainstem of the cat to esophageal distension following acute acid infusion.  Gastroenterology 2001; 120(5):A 58.   

  38. Sengupta JN, Shaker R, Medda BK.  GABAB receptor agonist baclofen attenuates responses of mechanosensitive pelvic nerve afferents of the rat to colorectal distension. Gastroenterology 2001; 120(5): A 641.

  39. Lang IM, Medda BK, Shaker R. The effect of baclofen on esophageal and pharyngeal reflexes. Gastroenterology 2001; 120(5): A 58.

  40. Lang IM, Kern M, Medda BK, and Shaker R. Application of FMRI technique of cerebrocortical control of the digestive tract function in cats. Gastroenterology 2002, 122(4), A156

  41. Lang IM, Dean-Bernhoft C, Medda BK, and Shaker R. Differential activation of vagal motor nuclei during different phages of swallowing. Gastroenterology,2002, 122(4), A308.

  42. Medda BK, Lang IM and Shaker R. Characterization of a pharyngo-gastric inhibitory reflex in the cat. Gastroenterology 2002, 122(4), A555.

  43. Sengupta JN, Medda BK, Petersen J, and Shaker R. Mechanical and chemical properties of distension-sensitive vagal afferents innervating the esophagus of rats. Gastroenterology, 2002, 122(4), A155.

  44. Lang IM, Kern M, Medda BK, Shaker R. Comparison of cerebrocortical areas activated by esophageal or rectal distension using fMRI in cats. Gastroenterology, 2003, 124(4), A670.

  45. Lang IM, Dean-Bernhoft C, Medda BK, Aslam M and Shaker R. Comparison of brainstem nuclei activated due to physiologically versus electrically stimulated swallowing. Gastroenterology, 2003,124(4), A671.

  46. Lang IM, Haworth ST, Medda BK, Shaker R. Mechanisms of esophageal acidification-induced alterations in tracheobronchial function. Gastroenterology, 2004, 126(4), A41.

  47. Sengupta JN, Medda BK, Peles Shachar and Shaker R. Effect of intraesophageal acid on

  48. responses of laryngeal muscles and motor neurons. Gastroenterology, 2004, 126(4), A99.

  49. Peles Shachar, Lehmann A, Medda BK, Shaker R and Sengupta JN. Effect of selective vanilloid receptor 1 (VR1) antagonist JYL1421 on capsaicin and acid-induced activation of vagal afferent fibers in the esophagus. Gastroenterology, 2004, 126(4), A336.

  50. Banerjee B, Medda BK, Shaker R and Sengupta JN. Effect of reflux-induced esophageal inflammation on vanilloid receptor (TRPV1/vrl) and substance P (sp) in spinal cord (sc) and dorsal root ganglia(DRG). Gastroenterology, 2005, 128(4), A220.

  51. Lang IM, Medda BK, Gray M and Shaker R. Esophageal acidification and distension activate different sets of medullary vagal nuclei (mvn). Gastroenterology, 2005, 128(4), A372.

  52. Lang IM, Gray M, Medda BK and Shaker R. The brain areas activated during motion sickness. Gastroenterology, 2005, 128(4), A373.

  53. Banerjee B, Medda BK, Sengupta JN and Shaker R. Acid exposure increase TRPV1 channel expression in spinal afferents innervating the esophagus. Gastroenterology, 2006, 130(4), A74.

  54. Banerjee B, Medda BK, Shaker R and Sengupta JN.  TRPV1 and P2X3 expression in vagal and spinal pathways following acid induced esophagitis in rats. Gastroenterology, 2006, 130(4), A133.

  55. Lang IM, Haworth ST, Medda BK, Shaker R. The effect of esophageal acidification on Airway mucociliary function. Gastroenterology, 2006, 130(4), A139.

  56. Lang IM,  Medda BK, Shaker R. The esophagus is topographically organized in the brainstem according to peripheral location as well as receptor type. Gastroenterology, 2006, 130(4), A444.

  57. Zheng Y, Medda BK, Banerjee B, Komorowski R, Sengupta JN, Shaker R. Prevention of Gastroesophageal reflux induced ulceration by selective TRPV1 receptor antagonist in rats. Gastroenterology, 2007, 132(4), A275.

  58. Banerjee B, Medda BK, Zheng Y, Sengupta JN, Shaker R. Upregulation of NMDA-NR1 Subunites in the dorsal root ganglia (DRG) and esophagus following acid exposure in cats. Gastroenterology, 2007, 132(4), A582.

  59. Lang IM, Medda BK, Shaker R. Acid in the cervical or thoracic portions of the esophagus Activates different sets of medullary nuclei. Gastroenterology, 2007, 132(4), A718.

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