Infectious Diseases

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Welcome

Welcome to the Division of Infectious Diseases in the Department of Medicine at the Medical College of Wisconsin website.   The website introduces each of our division’s faculty with a description of their backgrounds. Potential trainees can learn more about our clinical and research activities. The website is updated frequently to bring current information to our visitors.

 
The Division of Infectious Diseases has three main missions: public service; education; and research. Our public service mission is manifested primarily through our clinical care of patients with infectious diseases, but also through interactions with hospitals, health care providers, public health departments and other community agencies. Our education mission includes efforts across a broad spectrum of learners, including medical and other health care professional students, residents and fellows, and continuing education for practicing physicians, as well as community education in areas of infectious diseases. We conduct basic and clinical research in the areas of HIV/AIDS, HIV prevention strategies, human retrovirology (HTLV), bacterial pathogenesis, host-parasite interactions, hospital epidemiology and infection control.
 
Our clinical activities and training programs are centrally based at the Medical College of Wisconsin and Froedtert Hospital and Clinics and the Clement Zablocki VA Medical Center. Additionally, our faculty and housestaff are affiliated with Children’s Hospital of Wisconsin, St. Joseph’s Hospital (Milwaukee), St. Joseph’s Hospital (West Bend), and the AIDS Resource Center of Wisconsin.
 
Sincerely,
 
Mark A. Beilke, M.D.
Professor of Medicine

Welcome ID Faculty!

2013 has brought the Division of Infectious Diseases three faculty members who have already done so much for the Division, Department and the College. Let's meet them...

Krutika Kuppalli, MD

Dr. Kuppalli came to MCW after completing her postdoctoral fellowship in Global Public Health, University of California, San Diego, CA, where she received her Bachelor of Science in Biochemistry/Biology and her Bachelor of Arts in Internal Relations. She attended Emory University, School of Medicine, Atlanta, GA where she completed her research fellowship and her clinical fellowship in Infectious Diseases, and her internship and residency in Internal Medicine.  She received her Medical Degree from Virginia Commonwealth University, School of Medicine. Dr. Kuppalli is working out of the at FMLH and at ARCW, and working on ID consults at FMLH.

Maheen Abidi, MD, FACP

Dr. Abidi came to MCW from Mayo Clinic, Rochester, MN where she completed her Transplant Infectious Diseases fellowship. She also completed her Infectious Diseases fellowship at Strong Memorial Hospital, University of Rochester, Rochester, NY, and her Geriatric Medicine fellowship at Oregon Health and Sciences University, PVAMC, Portland, OR. She completed her residency at Michael Reese Hospital, University of Illinois, Chicago, IL. She received her Bachelor of Medicine and Bachelor of Surgery from Dow University of Health Sciences, Karachi, Pakistan. Dr. Abidi is working out of the Infectious Diseases clinic and on ID and ID-transplant consults at FMLH.

Carlos Figueroa Castro, MD

Dr. Figueroa Castro came to MCW from Boone Hospital Center in Columbia, MO. He completed an internship and his residency at MCW and completed his fellowship at Creighton University, Omaha, NE. He received his medical degree from the Universidad El Bosque, Bogota, Columbia and his graduate certificate in Public Health from the University of Missouri, Columbia, MO. Dr. Figueroa Castro is working at the St. Joe's clinic in West Bend, at the St. Agnesian clinic in Fond du Lac, and at the Infectious Diseases clinic at FMLH.

Welcome, and Thank You!

“Metamorphic” protein could lead to new AIDS-fighting drugs

Dec. 26, 2013 College News - The Medical College of Wisconsin (MCW) has received a one-year, $353,000 grant from the National Institutes of Health’s National Institute of Allergy and Infectious Diseases (NIAID) to study a unique protein that shows promise as an HIV inhibitor.

Brian Volkman, PhD, Professor of Biochemistry, is the primary investigator of the grant.

The United Nations estimates that more than 35 million people worldwide are living with HIV, the virus which causes AIDS.  There is no cure for HIV, but a variety of medications can be used to control the virus. In this project, Dr. Volkman’s team will investigate the characteristics of ‘metamorphic’ proteins, a newly discovered class of proteins which are unlike typical proteins in that they transform between two specific folded arrangements. Lymphotactin, a prototypical metamorphic protein, was recently shown to bind HIV particles and to inhibit infection of T cells.  In a study published in PLoS Pathogens, (http://dx.plos.org/10.1371/journal.ppat.1003852) Paolo Lusso, PhD, a scientist at NIAID, and his team at compared the antiviral activity of various lymphotactin proteins designed and produced in Dr. Volkman’s lab.

Christina Guzzo, PhD, is lead author of the paper. Other co-authors at NAIAD include Yin Lin, PhD; Huiyi Miao, PhD; Raffaello Cimbro, PhD; and Anthony Fauci, PhD. MCW contributors are Dr. Volkman and Jamie Fox, PhD. The study was supported by NIH grant R01AI063325.

Because an engineered version of lymphotactin that is locked into one of the two folded arrangements lost the ability to bind or inhibit HIV, the ability to transform appears to be necessary for its biological function.  The new project will fund experiments in Dr. Volkman’s lab to determine whether the metamorphic behavior of lymphotactin is important for inhibition of HIV or other human pathogens.

Once its antiviral activity is understood in the context of the metamorphic structure, lymphotactin may be developed as the lead compound in a new class of HIV-1 inhibitors with the potential to reduce the health burden of HIV/AIDS.

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