Infectious Diseases

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Bench Research

Laboratory of Dr. Mark Beilke - MCW and the Zablocki VA Medical Center

Dr. Beilke joined the Medical College of Wisconsin as Chief of Infectious Diseases in September 2006.   His research interests include HIV-1 and HTLV-1/2 infections.  Fellows and students will have the opportunity to learn a variety of virology techniques, including ELISA, Western Blot, sterile tissue culture techniques, and virus isolation. In 2002, Dr. Beilke received a 5-year, $1.7 million R01 award from the NIH/NIAID to study the health effects of HTLV-I and HTLV-II as cofactors during HIV infection. Recent Publications

 

 

"Flower cell" from an HTLV-1 infected individual - Shuh, M and Beilke, M (2005), Microscopy Research and Technique 68: 176-196.

 

Laboratory of Dr. Jenifer Coburn - Translational Biomedical Research Center

The Coburn Lab is interested in how the pathogenic spirochetes Borrelia burgdorferi and Leptospira interrogans interact with mammalian cell surface receptors to facilitate establishment of disseminated infection.  We use approaches from Biochemistry, Molecular Biology, Cell Biology, and classical Microbiology to identify specific host cell receptors, the bacterial proteins that bind those receptors, and to understand the consequences of those interactions. Work in the Coburn Lab is funded by three grants from the NIH.  For more information and published lists, go to Coburn Lab.

 

 

Ixodes scapularis nymph, photograph taken by Dorothee Grimm, PhD

Borrelia burgdorferi attached to a human platelet, photograph from Coburn et al, (1993) PNAS 90: 7059-7063

Leptospira interrogans attached to human epithelial cell, photograph taken by Denise Martinez

 

 

Laboratory of Dr. Michael Kron - Biotechnology Bioengineering Center

 

Dr. Kron presently serves as the principal investigator on a National Institutes of Health-funded collaborative study to identify compounds that might be useful in treating human filiarial diseases, which infect millions of persons.  For more information please visit the Kron Lab page.  Recent Publications

 

Laboratory of Dr. Peter Sohnle - Zablocki VA Medical Center

Study of Cutaneous Host Defenses:  The laboratory of Dr. Peter Sohnle at the Milwaukee VAMC has a long-standing interest in the mechanisms used by the host to prevent or clear infections with various pathogens.  At the present time the work involves the pathogens Candida albicans and Bacillus anthracis.  Animal models of each infection have been developed and are being studied by a variety of techniques. Recent Publications

 

 

Superficial exudate neutrophils from a highly resistant athymic nude mouse ingesting Bacillus anthracis bacilli at the skin surface 6 hours after inoculation.

Watts CJ, Hahn BL, Sohnle PG. Resistance of athymic nude mice to experimental cutaneous anthrax. J Infect Dis 199: 673-9, 2009

 

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