Infectious Diseases

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Bench Research

Laboratory of Dr. Mark Beilke - MCW and the Zablocki VA Medical Center

Dr. Beilke is Professor and Chief of Infectious Diseases at the Clement Zablocki VA Medical Center, where his laboratory is located.  Dr. Beilke has a longstanding research interest in the co-interactions of HIV-1, HTLV-1 and HTLV-2, which are the first three human retroviruses isolated and characterized in the 1980's.  Between 1991 and 2006 at Charity Hospital, New Orleans, Dr. Beilke conducted investigations on approximately 225 patients into an NIH-funded retrospective and prospective observational study.  The research indicated that HTLV infections conferred a survival benefit among patients with HIV-HTLV co-infections.

The clinical research studies were prematurely curtailed as a result of Hurricane Katrina.  However, the work resulted in sentinel clinical findings which lead to several peer reviewed publications.  When Dr. Beilke joined the Medical College of Wisconsin, in 2006, he established a hypothesis driven laboratory study built upon data obtained from the clinical cohort study.  The HTLV-2 viral transactivating protein, known as Tax2, is interesting because it appears to have potent effects on the human immune system.  Not only does Tax2 upregulate CC-chemokines, it also down-regulates the CCR-5 chemokine receptor which is utilized by R5 tropic strains of HIV-1.  The long term goal of Dr. Beilke's laboratory is to develop small peptides derived from the Tax2 amino acid sequence with potential therapeutic efficacy as immunomodulators and potential microbicides for protection of sexual transmission of HIV-1 and other sexually transmitted infections.

Recent Publications

 

 

"Flower cell" from an HTLV-1 infected individual - Shuh, M and Beilke, M (2005), Microscopy Research and Technique 68: 176-196.

 

Laboratory of Dr. Jenifer Coburn - Translational Biomedical Research Center

The Coburn Lab is interested in how the pathogenic spirochetes Borrelia burgdorferi and Leptospira interrogans interact with mammalian cell surface receptors to facilitate establishment of disseminated infection.  We use approaches from Biochemistry, Molecular Biology, Cell Biology, and classical Microbiology to identify specific host cell receptors, the bacterial proteins that bind those receptors, and to understand the consequences of those interactions. Work in the Coburn Lab is funded by 4 grants from the NIH.  For more information and published lists, go to Coburn Lab.

 

 

Ixodes scapularis nymph, photograph taken by Dorothee Grimm, PhD

Borrelia burgdorferi attached to a human platelet, photograph from Coburn et al, (1993) PNAS 90: 7059-7063

Leptospira interrogans attached to human epithelial cell, photograph taken by Denise Martinez

 

 

Laboratory of Dr. Michael Kron - Biotechnology Bioengineering Center

 

Dr. Kron presently serves as the principal investigator on a National Institutes of Health-funded collaborative study to identify compounds that might be useful in treating human filiarial diseases, which infect millions of persons.  For more information please visit the Kron Lab page.  Recent Publications

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Page Updated 10/30/2014