Lab UpdatesMedical College of Wisconsin Dwinell Laboratory Updates

Dr. Dwinell featured in Milwaukee Journal Sentinel as Milwaukeean of the Week.

The Milwaukee Journal Sentinel named Protein Foundry one of ten startups with great potential in southeast Wisconsin. Protein Foundry was founded by Brian Volkman, PhD, professor of biochemistry; and Michael Dwinell, PhD, professor of microbiology and molecular genetics.

Dr. Dwinell participated in the For Your Health program on WTMJ’s Wisconsin Weekend radio program with Steve Daniels. Dr. Dwinell discussed his recent grant support and its potential impact on pancreas cancer at MCW.

The lab participated in the Grand Opening celebration of Protein Foundry, LLC. Protein Foundry is a chemokine production biotech startup founded by Dr. Brian Volkman and Dr. Francis Peterson. Dr. Dwinell and Chad Koplinski are co-founders.
Milwaukee Journal Sentinel article, July 26, 2014

Ishan Roy successfully defended his doctoral dissertation entitled: “Roles for chemokines in pancreatic cancer metastasis.” Dr. Anirban Maitra from the MD Anderson Cancer Center at the University of Texas was the external reviewer on the dissertation committee.

Ishan Roy and Dr. Dwinell traveled to New Orleans, LA to attend the American Association for Cancer Research Pancreatic Cancer: Innovations in Research and Treatment meeting. Ishan participated in a poster presentation of his abstract “Chemokine biased agonists regulate pancreatic cancer migration and metastasis through bioenergetic signaling.” The work is a collaboration with Drs. Evans and Tsai from the Department of Surgery as well as Drs. Kalyanaraman and Cheng from the Department of Biophysics and Dr. Volkman and Anthony Getschman from the Department of Biochemistry.

Ishan Roy attended the 2014 meeting of the American Gastroenterological Association in Chicago, IL. Ishan had a poster presentation entitled “CXCL12 suppresses pancreatic cancer by regulating tumor cell growth, migration, and metastatic homing”.

The laboratory hosted, in collaboration with the Medical Scientist Training Program, the visit of Dr. David Tuveson, Professor and Deputy Director, Cold Spring Harbor Laboratory Cancer Center, Director of Research, the Lustgarten Foundation. Dr. Tuveson’s research and clinical activities are focused on expanding the Foundation's research efforts and accelerating the movement of successful results from the lab into clinical trials to directly impact the treatment of individuals with pancreatic cancer. Dr. Tuveson’s seminar presentation was entitled “Pancreatic Cancer Biology and Medicine.”

The laboratory welcomed Donna McAlister to the team. Donna assumed duties as a Research Technologist and Laboratory Manager.

Ishan Roy and Dr. Dwinell presented their work “CXCL12 is a multifunctional tumor suppressor of pancreatic cancer” at the Inaugural MCW Cancer Center Scientific Retreat.

The laboratory hosted the visit of Dr. Kenneth Olive, Assistant Professor of Pathology and Medicine, Columbia University Medical Center. Ken presented some his latest research at a well-attended and outstanding seminar entitled “Preclinical Therapeutics in Genetically Engineered Models of Pancreatic Cancer.” The seminar was part of the Cancer Cell Biology Research Forum.

Dr. Dwinell was a Visiting Professor at Loyola University Chicago Stritch School of Medicine. His seminar was entitled “Controlling tumor metastasis with chemokines.”

Ishan Roy traveled to Lake Tahoe, NV, to attend the American Association for Cancer Research meeting entitled “Pancreatic Cancer: Progress and Challenges”. Ishan presented his work in an abstract entitled “CXCL12 and CXCR4 are reciprocally expressed in normal pancreatic ducts and pancreatic ductal adenocarcinoma respectively.” This work was aided by a collaboration with Dr. Doug Evans, Chair, and Dr. Susan Tsai, both in the Department of Surgery and coauthors of the poster presentation.

The laboratory hosted the visit of Dr. Lars Eckmann, Professor, University of California, San Diego. Lars gave an outstanding seminar on the use of high-throughput medicinal chemistry to define novel therapeutics against Giardia lamblia, a common water-borne pathogen. Dr. Eckmann’s seminar was entitled “Bioactivity Landscapes of Nitroimidazole Antimicrobials: Old Drugs, New Tricks.”

The laboratory hosted the visit of Dr. Keith R. Johnson, Professor, NCCS Director, Department of Oral Biology and The Eppley Institute, University of Nebraska Medical Center. Dr. Johnson was the external examiner for Soony’s doctoral dissertation.

Soonyean Hwang successfully defended his doctoral dissertation entitled: “The role and regulation of E-cadherin during basal and CXCL12 induced cell migration.”

Soonyean Hwang and Dr. Dwinell attended the 2012 meeting of the American Gastroenterological Association in San Diego, CA. Soony gave an oral presentation titled “Chemokine signaling regulates E-cadherin localization through a ROCK and F-actin dependent mechanism during intestinal epithelial restitution.”

The laboratory hosted the visit of Dr. Anna Huttenlocher from the University of Wisconsin. Dr. Huttenlocher was the external examiner for Kim Agle's doctoral dissertation defense.

Kim Agle successfully defended her doctoral dissertation entitled: "Chemokines orchestrate dynamic cellular responses: Roles in calcium regulated integrin activation."

Soony Hwang's abstract entitled "Chemokine signaling regulates E-cadherin localization through a ROCK and F-actin dependent mechanism during intestinal epithelial restitution" to the American Gastroenterological Association annual meeting in Chicago was accepted for an oral presentation. Soony will present his work on the first day of the conference in San Diego, CA.

Dr. Dwinell, Dr. Zimmerman, and Ishan Roy attended the annual American Association for Cancer Research meeting in Chicago, IL. Dr. Zimmerman presented a poster entitled "Elevated cAMP decreases migratory potential in pancreatic cancer cells". The meeting had close to 30,000 registered cancer research scientists and physicians participating in the 5-day conference.

The laboratory hosted Dr. Declan McCole. Declan was a visiting professor from the Department of Medicine at the University of California, San Diego. Dr. McCole gave a superb seminar presentation on his work in "Epithelial Barrier Protection by the Inflammatory Bowel Disease-Associated Gene PTPN2."

Dr. Dwinell was a Visiting Professor at the Center for Cancer and Blood Disorders, Gundersen Lutheran Medical Foundation in La Crosse, WI. He gave an invited research seminar titled "Controlling tumor cell metastasis with chemokines" as part of the La Crosse BioResearch Forum.

Dr. Dwinell was a Visiting Professor at Ferris State University in Big Rapids, MI. His invited research seminar "Inhibiting tumor metastasis with chemokines: A tale of two graduate students" was presented.

Footage of Ishan Roy working in the Dwinell lab was part of a video for the We Care Fund. The video was shown at Sept 9th's Milwaukee Brewers game. The We Care Fund supports labs like the Dwinell lab with the goal of accelerate the development of advanced, life-saving solutions in the fields of cancer, cardiovascular disease, organ transplantation, and trauma. Dr Michael Dwinell is a member of the scientific committee for the We Care Fund.

Dr. Luke Drury and his family moved to Iowa City following his acceptance of a postdoctoral position in the laboratory of Dr. Dupuy in the Department of Anatomy & Cell Biology at the Carver College of Medicine, University of Iowa. We wish Luke the best of luck and look forward to hearing about his postdoctoral research.

Yana Thaker (M1) received an Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship and will complete her summer research investigating the mechanisms of CXCR4 internalization in human colon cancer cells.

Dr. Dwinell attended the annual meeting of the American Gastroenterology Association during DDW2011 in Chicago, IL. He presented the latest research findings of Dr. Luke Drury and Dr. Noah Zimmerman at the conference. Luke’s data indicates that the oligomeric state of the chemokine CXCL12 may differentially regulate the ability of colon cancer cells to migrate, while Noah’s findings demonstrate a key role for cAMP levels in overall mobility of intestinal epithelial cells in vivo and in vitro.

Ishan Roy and Dr. Dwinell attended the 45th annual meeting of the Pancreas Club. The meeting was held at the Robert H. Lurie Medical Research Center at Northwestern University in Chicago, IL.

Dr Dwinell was a Visiting Professor at the University of Southern California in Los Angeles, CA. The Saban Research Institute of Children's Hospital Los Angeles hosted his visit during which he gave a seminar titled "Controlling epithelial cell migration in inflammation and cancer."

Ishan Roy was accepted to attend the Cold Spring Harbor Laboratory’s Workshop on Foundations of Pancreatic Cancer (C-PANCAN) June 16 – June 22, 2011 at Banbury Conference Center in Lloyd Harbor, NY.

The laboratory hosted the visit of Dr. Nikolaus Heveker. Dr. Heveker was the external examiner for Luke Drury’s doctoral dissertation defense and gave an outstanding seminar entitled "The SDF-1-binding chemokine receptors CXCR4 and CXCR7 – News from the odd couple."

Luke Drury successfully defended his doctoral dissertation entitled "Mechanisms of CXCL12 inhibition of metastasis: Unveiling a new cancer therapeutic."

Dr. Dwinell participated in Colon Cancer Awareness event at the Cancer Center. His presentation was titled "How a Gift Translates into Advances of Colorectal Cancer: The Bobbie Nick Voss Charitable Funds for Colon Cancer."

Dr. Zimmerman's abstract to the American Gastroenterological Association annual meeting in Chicago was accepted for a video presentation in conjunction with his poster presentation. Luke Drury’s abstract was accepted for presentation as a poster of distinction.

Dr. Dwinell was a Visiting Professor at Northwestern University, Chicago. His seminar, entitled "Shifting the paradigm: chemokine regulation of tumor metastasis" was hosted by the Tumor Cell Biology program, Robert H. Lurie Comprehensive Cancer Center.

Kimberle Agle has had her abstract to Experimental Biology 2011 accepted for an oral presentation. She will be presenting at the EB2011 meeting in Washington DC in April.

Dr. Dwinell gave a seminar at the Children's Research Institute at Children's Hospital of Wisconsin.

Members of the Dwinell laboratory scheduled to give seminars during the upcoming semester include Luke Drury (September 3rd), Soony Hwang (September 10), Kim Agle (November 5) and Ishan Roy (November 17).

Dr. Dwinell gave a research seminar to the Division of Infectious Disease at Medical College of Wisconsin. His seminar, titled “Roles for chemokines in inflammation and injury” highlighted the key role for the intestinal epithelium in host defense to enteric pathogens and discussed the laboratory’s research efforts to improve epithelial migration in response to damage.

The laboratory welcomed Ishan Roy to the research team. As a student in the Medical Scientist Training Program, Ishan has completed his first two years of medical school and has embarked on his doctoral studies investigating the role for chemokines in pancreatic cancer tumorigenesis.

The laboratory wished a fond and sad farewell to Sheena Faherty who has moved to Duke University to pursue a doctorate in biological sciences.

Dr. Noah Zimmerman attended the Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases at the Waterville Valley Resort, New Hampshire. He presented his latest findings demonstrating that cAMP negatively regulates intestinal epithelial cell wound repair through protein kinase A and the monomeric GTPase Rho.

Luke Drury received a travel award from the MCW Graduate Studied Council to attend the Gordon Research Conferences: Chemotactic Cytokines in Il Ciocco Hotel and Resort, Lucca (Barga) ITALY. While at the meeting he presented a poster on his work examining the role for chemokines as key regulators of tumor cell metastasis. Our collaborators, Dr. Brian Volkman and Josh Ziarek from the Department of Biochemistry, also attended the meeting.

Soonyean Hwang's abstract has been chosen for a 15 minute talk at the upcoming Annual Meeting of the American Gastroenterological Association.



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