Stephen Gauld, PhD
Pediatrics - Division of Allergy and Immunology, Microbiology and Molecular Genetics
Medical College of Wisconsin
Research Focus: B cell anergy, role of follicular helper T cells and regulatory T cells in the regulation of B cell anergy, genetic and viral control of autoantibody production in lupus.
PhD: University of Glasgow (2001) Immunology
My research interests focus on B cell anergy, a major mechanism of B cell tolerance that prevents auto-reactive B cells from secreting autoantibodies. Previous work in my laboratory has shown that B cell anergy is dependent on the presence of regulatory T cells. My laboratory is currently working out the mechanisms by which regulatory T cells control B cell anergy. One possible mechanism is that the absence of regulatory T cells promotes the expansion of a specific helper T cell population that directly interact with anergic B cells, promoting the loss of B cell anergy. Interestingly, my laboratory has observed a similar mechanism in lupus-prone mice, as well as a model of virus-induced autoantibody production. My laboratory is therefore defining whether defects in regulatory T cells are central to the loss of B cell anergy in these systems.
Fluorescent microscopy image showing differences in the structure of the red pulp of spleens from wild-type and regulatory T cell deficient mice (Foxp3-deficient mice). The red areas represent the B cell follicles, while the green areas represent the T cell zones.
Dr. Stephen Gauld
MACC Fund Research Building, Rm 5065
8701 W Watertown Plank Road
Milwaukee, WI 53212