Medical Scientist Training Program

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Alexander Dayton

adayton@mcw.edu

Research Interest

  • Advisor: Allen W Cowley Jr PhD, Department of Physiology

Education

  • B.A. 2009, Hanover College
    • Majors: Chemistry, Math

Research Experience

  • Indiana University, 2007
    • Research Assistant
  • The Ohio State University, 2009-2011
    • Research Assistant

Publications

  • He S, Dayton A, Kuppusamy P, Werbovetz KA, Drew ME.  Induction of oxidative stress in Trypanosoma brucei by the antitrypanosomal dihydroquinoline OSU-40.  Antimicrob Agents Chemother.  2012 May;56(5):2428-34.  Epub 2012 Feb 6.

  • Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Rivera BK, Kálai T, Hideg K, Kuppusamy P.  HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.  Cancer Biol Ther.  2011 Nov 1;12(9):837-45.  Epub 2011 Nov 1.

  • Dayton A, Selvendiran K, Meduru S, Khan M, Kuppusamy ML, Naidu S, Kálai T, Hideg K, Kuppusamy P.  Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867.  J Pharmacol Exp Ther.  2011 Nov;339(2):350-7.  Epub 2011 Jul 28.

  • Dayton A, Selvendiran K, Kuppusamy ML, Rivera BK, Meduru S, Kálai T, Hideg K, Kuppusamy P.  Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.  Cancer Biol Ther.  2010 Nov;10(10):1027-32.  Epub 2010 Nov 15.

  • Selvendiran K, Ahmed S, Dayton A, Ravi Y, Kuppusamy ML, Bratasz A, Rivera BK, Kálai T, Hideg K, Kuppusamy P.  HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.  Mol Cancer Res.  2010 Sep;8(9):1188-97.  Epub 2010 Aug 16.

  • Selvendiran K, Ahmed S, Dayton A, Kuppusamy ML, Tazi M, Bratasz A, Tong L, Rivera BK, Kálai T, Hideg K, Kuppusamy P.  Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells.  Free Radic Biol Med.  2010 May 1;48(9):1228-35.  Epub 2010 Feb 12.

Interests

  • Soccer, Video Games, Books
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