Medical Scientist Training Program

Jamie Privratsky, PhD

4th Year Medical Student
8th Year MSTP

jprivrat@mcw.edu

Research Interests

• Leukocyte and endothelial cell signaling in inflammation; vascular barrier function.

Education

• B.S. 2004, University of North Dakota
• Major: Clinical Laboratory Science

Research Experience

• University of North Dakota, 3 years
  • Advisor: Dr. Jun Ren
  • Project: The role of angiotensin 1 receptor antagonism and oxidative stress in diabetic and oxidative cardiomyopathy
• Medical College of Wisconsin, 3 years
  • Advisor: Dr. Peter Newman
  • Project: The anti-inflammatory role of PECAM-1 in cytokine production and vascular permeability

Publications

• Privratsky JR, Wold LE, Quinn MT, Sowers JR , Ren J: AT1 blockade prevents glucose-induced cardiac dysfunction in ventricular myocytes: role of the AT1 receptor and NAD(P)H oxidase. Hypertension. 42(2):206-212, 2003.
• Aberle II NS, Privratsky JR, Burd L, Ren J: Combined acetaldehyde and nicotine exposure depresses cardiac contraction in ventricular myocytes: prevention by folic acid. Neurotoxicol Teratol. 25:731-736, 2003.
• Li SY, Golden KL, Jiang Y, Wang GJ, Privratsky JR, Zhang X, Eason AR, Culver B, Ren J: Inhibition of Sarco(endo)plasmic Reticulum Ca2+-ATPase Differentially Regulates Contractile Function in Cardiac Myocytes From Normotensive and Spontaneously Hypertensive Rats: Role of Ca2+ Regulatory Proteins. Cell Biochem Biophys. 42(1):1-12, 2005.
• Wold LE, Ceylan-isik AF, Fang CX, Yang X, Li SY, Sreejayan N, Privratsky JR, Ren J: Metallothionein Alleviates Cardiac Dysfunction in Streptozotocin-Induced Diabetes: Role of Ca2+ Cycling Proteins, NADPH Oxidase, Poly(ADP-Ribose) Polymerase and Myosin Heavy Chain Isozyme. Free Radic Biol Med. 40:1419-1429, 2006.
• Ren J, Privratsky JR, Yang X, Dong F, Carlson EC. Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts. Crit Care Med. 36(7):2106-2116, 2008.
• Ceylan-Isik AF, Guo KK, Carlson EC, Privratsky JR, Liao SJ, Cai L, Chen AF, Ren J. Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis. Hypertension. 53(6):1023-31, 2009.
• Privratsky JR, Newman PJ. The anti-inflammatory actions of PECAM-1 do not involve regulation of endothelial cell NFκB. J Immunol. 184(6):3157-63, 2010.
• Privratsky JR, Newman DK, Newman PJ. PECAM-1: Conflicts of Interest in Inflammation. Life Sci. xxx-xxx, 2010. In press.;
• Privratsky JR, Tilkens SB, Newman DK, Newman PJ. PECAM-1 dampens cytokine levels by preventing the excessive accumulation of cytokine-producing macrophages during LPS-induced endotoxic shock. J Immunol. In preparation.

Interests

• Spending time with my wife, Church activities/Bible studies, Golfing, Watching sports