Medical Scientist Training Program

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Karen Hansen

kahansen@mcw.edu

Research Interest

  • Thrombosis, Hemostasis and Vascular Biology
  • Advisor: Lisa Cirillo PhD, Department of Cell Biology, Neurobiology & Anatomy
  • Lab page

Education

  • M.S. 2006, Mayo Clinic College of Medicine
    • Molecular Neuroscience
  • B.S. 2004, College of Idaho
    • Major: Biology

Research Experience

  • Medical College of Wisconsin, Milwaukee, WI, 6/2001-8/2011
    • Summer Research Student
    • Advisor: Dr. David Harder in collaboration with Dr. Alan Mast, Dr. Anne Hoch
    • Project: Comparison of Growth Factors and Platelet Concentration and Activation from a Commercial Platelet Rich Plasma Separation System and a Standard Table Top Centrifuge
  • Medtronic Corporation, Minneapolis, MN, 5/2009-8/2010
    • CNS Therapy Program Coordinator
    • Provided project management support for CNS Drug Therapy products in the R&D pipeline.  Therapeutic landscapes included Alzheimer’s, Parkinson’s, and Huntington’s Diseases and Pain and Mood Disorders.  Developed Good Manufacturing Practice (GMP) plan for producing therapies for Phase I/II Clinical Trials.  Helped develop antibody for Alzheimer’s disease and established technology transfer with GMP manufacturer.
  • Humanetics Corporation, Minneapolis, MN, 2/2008-4/2009
    • Project Manager
    • Provided consulting support for product development of pharmacological countermeasures for ionizing radiation.
  • Acorda Therapeutics and University of Minnesota, St. Paul, MN, 7/2006-1/2008
    • Biopharmaceutical Engineer and Protein Production Program Manager
    • Developed GMP purification process for recombinant human monoclonal IgM biotherapeutic for Phase I Clinical Trials for Multiple Sclerosis.  Managed protein production and purification projects, including testing of all stages of master cell line development and protein manufacturing.
  • Mayo Clinic College of Medicine, Rochester, MN, 8/2004-6/2006
    • Biomedical Research Graduate Student
    • Advisor: Dr. Joseph Poduslo
    • Project: Performed pharmacokinetic analysis of the efflux of amyloid beta protein in Alzheimer disease transgenic mice.  Helped develop and analyze molecular probe-contrast agent for detection of plaques in parenchyma of Alzheimer brains using MRI.
  • Mayo Clinic, Rochester, MN, 6/2003-8/2003
    • Summer Undergraduate Research Fellow
    • Advisor: Dr. Mark McNiven
    • Project: Investigated direct interaction between actin-binding proteins, cortactin and dynamin, and their involvement in cell motility in pancreatic cancer.  Purified proteins and performed biochemical studies of protein interactions after post-translational modifications.

Publications

  • Giles KE, Kandimalla KK, Ramirez-Alvarado, Poduslo JF.  Development of Aβ40 derivatives that do not form fibrils as MRI contrast agents for detecting Alzheimer’s disease amyloid plaques.  Journal of Neurochemistry 2005: 94 (Supp 1), 27.

Interests

  • Running, cycling, triathlons, Telemark skiing, reading, and spending time with my husband.
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Page Updated 08/27/2013