Medical Scientist Training Program

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Sasha (Zheng) Prisco
M3

sprisco@mcw.edu

Research Interests

  • The genetic basis of cardiovascular and renal diseases
  • Physiological genomics
  • Advisor: Howard Jacob PhD, Department of Physiology

Education

  • BS 2008, University of Nebraska-Lincoln
    • Major: Biochemistry and Biological Sciences
  • PhD 2014, Medical College of Wisconsin
    • Physiology

Research Experience

  • University of Nebraska-Lincoln, 2005-2008
    • Advisor: You Zhou, PhD
    • Project: Molecular and Biochemical Characterization of the Mouse Lines with Polymorphic Glucocorticoid Receptors

Publications

  • Prisco SZ, Priestley JRC, Weinberg BD, Prisco AR, Hoffman MJ, Jacob HJ, Flister MJ, Lombard JH, Lazar J. Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12. AJP-Heart and Circulatory Physiology. 2014. (In Press)
  • Prisco SZ, Prokop JW, Sarkis AB, Yeo NC, Hoffman MJ, Hansen CC, Jacob HJ, Flister MJ, Lazar J. Refined mapping of a hypertension susceptibility locus on rat chromosome 12. Hypertension. 2014;64:883-890.
  • Lazar J, O'Meara CC, Sarkis AB, Prisco SZ, Xu H, Fox CS, Chen MH, Broeckel U, Arnett DK, Moreno C, Provoost AP, Jacob HJ. Sorcs1 contributes to the development of renal disease in rats and humans. Physiol Genomics. 2013;45:720-728.
  • Schuler BA*, Prisco SZ*, Jacob HJ. Using whole exome sequencing to walk from clinical practice to research and back again. Circulation. 2013;127:968-970. (*contributed equally).
  • Flister MJ, Prisco SZ, Sarkis AB, O'Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ. Identification of hypertension susceptibility loci on rat chromosome 12. Hypertension. 2012;60:942-948.
  • Zhou Y., S. Zheng, W. Sprout, J. McDonald, M. K. Nielsen. 2007. Additional evidence showing an additive effect of glucocorticoid receptor polymorphisms on anxiety-type behavior, stress response and body weight in a population of mice with low heat loss background. FASEB J.

Meeting Abstracts

  • Prisco SZ, Priestley JRC, Flister MJ, Sarkis AB, Hoffman M, Lazar J, Lombard JH, Jacob HJ. CHROMOSOME 12 and HYPERTENSION. Rat Genomics and Models. Cold Spring Harbor, NY. Dec 11-14, 2013.
  • Prisco SZ, Priestley JRC, Flister MJ, Sarkis AB, Hoffman M, Lazar J, Lombard JH, Jacob HJ. Chst12 and Grifin are candidate genetic modifiers of salt-sensitive hypertension. 23rd Annual Medical College of Wisconsin Research Poster Session. Oct 10, 2013. (Recipient of Poster Award)
  • Hansen C, Prisco SZ, Flister MJ, Sarkis AB, Hoffman M, Lazar J, Jacob HJ. Genetic dissection of hypertension on rat chromosome 12. Medical College of Wisconsin Medical Student Research Day Poster Session. Oct 3, 2013.
  • Prisco SZ, Jacob HJ. Dissecting Hypertension Susceptibility Loci on Rat Chromosome 12. 28th Annual National MD/PhD Student Conference. Keystone, CO. Jul 26-38, 2013. (Selected for Talk)
  • Flister MJ, Moreno C, Hoffman MJ, Prisco SZ, Lazar J, Hall JL, Jacob HJ. The inflammatory mediator SH2B3 increases risk of heart failure. Experimental Biology. Boston, MA. Apr 20-24, 2013.
  • Prisco SZ, Flister MJ, Sarkis AB, O’Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ. Dissecting Hypertension Susceptibility Loci on Rat Chromosome 12. Rat Genomics and Models. Cambridge, UK. Dec 3-6, 2012.
  • Flister MJ, Moreno C, Hoffman MJ, Prisco SZ, Lemke A, Lazar J, Jacob HJ. SH2B3 mutation increases risk of heart failure following myocardial infarction. Rat Genomics and Models. Cambridge, UK. Dec 3-6, 2012.
  • Prisco SZ, Flister MJ, Sarkis AB, O’Meara CC, Hoffman M, Wendt-Andrae J, Moreno C, Lazar J, Jacob HJ. Genetic dissection of hypertension with rat models. 22nd Annual Medical College of Wisconsin Research Day. Oct 18, 2012.
  • Raj N, Zheng S, Teich M, Dwinell M. An Evaluation of Non-invasive Echocardiography as an Indicator of Pulmonary Arterial Hypertension Compared Against invasive Measurements in Rattus Norvegicus. Medical College of Wisconsin Medical Student Research Day Poster Session. Oct 4, 2012.
  • Flister M, Jia S, Tsaih SW, Sarkis A, Zheng S, Geurts A, Moreno-Quinn C, Lazar J, Hessner MJ, Jacob H. GWAS nominated gene SH2B3 increases cardiac remodeling and inflammation associated with type 1 diabetes (T1D). Experimental Biology. San Diego, CA. Apr 21-25, 2012.
  • Zheng S, Flister MJ, Sarkis AB, Hoffman M, Moreno C, Lazar J, Jacob HJ. Narrowing genetic regions on rat chromosome 12 involved in cardiovascular disease. Rat Genomics and Models. Cold Spring Harbor, NY. Dec 7-10, 2011. (Selected for Talk)
  • Flister MJ, Zheng S, Sarkis AB, Hoffman M, Lemke A, Schilling RR, Tsaih S, Dwinell MR, Moreno-Quinn C, Lazar J, and Jacob HJ. Role of GWAS nominated gene SH2B3 in cardiac inflammation and remodeling. Rat Genomics and Models. Cold Spring Harbor, NY. Dec 7-10, 2011.
  • Xiao B, Hoffman M, Tsaih SW, Sarkis A, Flister M, Zheng S, Lemke A, O’Meara C, Lazar J, Jacob HJ, Moreno C. Identification of a gender-specific gene for salt-sensitive hypertension. Cold Spring Harbor, NY. Dec 7-10, 2011.
  • Zheng S, Flister MJ, Sarkis AB, Hoffman M, Moreno C, Lazar J, Jacob HJ. Genetic Dissection of Cardiovascular Disease with Rat Chromosome 12 Congenic Models. 21st Annual Medical College of Wisconsin Research Day. Oct 14, 2011.
  • Flister MJ, Zheng S, Sarkis AB, Hoffman M, Tsaih SW, Moreno-Quinn C, Lazar J, Jacob HJ. Role of GWAS Nominated Gene SH2B3 in Cardiac Inflammation and Remodeling. 21st Annual Medical College of Wisconsin Research Day. Oct 14, 2011.
  • Xiao B, Hoffman M, Tsaih SW, Sarkis A, Flister M, Zheng S, Lemke A, O’Meara C, Lazar J, Jacob HJ, Moreno C. Identification of a Gender-Specific Gene for Salt-Sensitive Hypertension. 21st Annual Medical College of Wisconsin Research Day. Oct 14, 2011.
  • Sarkis AB, Xiao B, Tsaih SW, Flister MJ, Lazar J, Lemke A, Zheng S, Hummel O, Saar K, Hübner N, Worthey EA, Jacob HJ, Moreno Quinn CP. Whole-genome SNP Map Of The Dahl Salt-sensitive And The Fawn-hooded Hypertensive Rats. American Heart Association’s High Blood Pressure Research 2011 Scientific Sessions. Abstract #828, Orlando, FL. Sept 21-24, 2011.
  • Zheng S, Lemke A, Lazar J, Badic A, Wakatsuki T, Jacob HJ. Engineered Heart Tissue as an in vitro rat model for studying the effect of myocardial ischemia. 20th Annual Medical College of Wisconsin Research Day. Sept 15, 2010.
  • Zhou Y, Xu D, Chen H, Zheng S, Nielsen MK. Mice from lines selected for either high or low stress response exhibit marked differences in spatial learning and memory. The 37th Annual Meeting of Society for Neurosciences. Abstract #2007-A-116213-SfN, San Diego, CA. Nov 6, 2007.
 

Interests

  • Reading, spending time with family, friends, and my dog.
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