Neurology

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Bradley C. Hiner, MD

Professor of Neurology
Director, Neurosciences Ambulatory Clinics
Neurologic Director, Deep Brain Stimulation Program

Specialty: Adult Neurology

Sub-Specialty:

  • Parkinson's Disease
  • Botulinum Toxin Injection For Dystonia
  • Movement Disorders
  • Deep Brain Stimulation (DBS)
  • Autonomic Disorders
  • Spasticity

Education:

  • Doctor of Medicine, Ohio State University College of Medicine, Columbus, 1982

Training:

  • Internship, Riverside Methodist Hospitals, Columbus, OH, 1982-1983
  • Residency, Neurology, Stanford Medical Center, CA, 1983-1985
  • Administrative Chief Resident, Neurology, Stanford Medical Center, CA, 1985-1986
  • Postdoctoral Neurosciences Fellowship, Stanford Medical Center, CA, 1986-1987

Board Certification:

  • Neurology

Brief Clinical/Research Interest Statement:

Dr. Hiner specializes in movement disorders. His focus is deep brain stimulation, an exciting new surgical procedure available at Froedtert & the Medical College of Wisconsin. Dr. Hiner is committed to improving the activities of daily living for his patients.

More information about the Parkinson's Movement Disorders program can be found at

http://www.froedtert.com/SpecialtyAreas/ParkinsonsMovementDisorders/


Publications:

  1. Fernandino L, Conant LL, Binder JR, Blindauer K, Hiner B, Spangler K, Desai RH. Where is the action? Action sentence processing in Parkinson's disease. Neuropsychologia 2013 Apr 25: PMID 23624313
  2. Nandedkar SD, Sheridan C, Bertoni S, Hiner BC, Barkhaus PE. Deep brain stimulator artifact in needle electromyography: effects and distribution in paraspinal and upper limb muscle. Muscle Nerve 2013 Apr;47(4):561-5 PMID 23463685
  3. Fernandino L, Conant LL, Binder JR, Blindauer K, Hiner B, Spangler K, Desai RH. Parkinson's disease disrupts both automatic and controlled processing of action verbs. Brain Lang 2012 Aug 18: PMID 22910144
  4. Alcalay RN, Caccappolo E, Mejia-Santana H, Tang M-, Rosado L, Orbe Reilly M, Ruiz D, Ross B, Verbitsky M, Kisselev S, Louis E, Comella C, Colcher A, Jennings D, Nance M, Bressman S, Scott WK, Tanner C, Mickel S, Andrews H, Waters C, Fahn S, Cote L, Frucht S, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Payami H, Molho E, Factor S, Ottman R, Clark LN, Marder K. Cognitive performance of GBA mutation carriers with early-onset PD: the CORE-PD study. Neurology 2012 May 1;78(18):1434-40 PMID 22442429
  5. Srivastava A, Tang MX, Mejia-Santana H, Rosado L, Louis ED, Caccappolo E, Comella C, Colcher A, Siderowf A, Jennings D, Nance M, Bressman S, Scott WK, Tanner C, Mickel S, Andrews H, Waters C, Fahn S, Cote L, Frucht S, Ford B, Alcalay RN, Ross B, Orbe Reilly M, Rezak M, Novak K, Friedman JH, Pfeiffer RD, Marsh L, Hiner B, Merle D, Ottman R, Clark LN, Marder K. The relation between depression and parkin genotype: the CORE-PD study. Parkinsonism Relat Disord 2011 Dec;17(10):740-4 PMID 21856206
  6. Ramírez RR, Kopell BH, Butson CR, Hiner BC, Baillet S. Spectral signal space projection algorithm for frequency domain MEG and EEG denoising, whitening, and source imaging. Neuroimage 2011 May 1;56(1):78-92 PMID 21315157
  7. Alcalay RN, Siderowf A, Ottman R, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Louis E, Ruiz D, Waters C, Fahn S, Cote L, Frucht S, Ford B, Orbe-Reilly M, Ross B, Verbitsky M, Kisselev S, Comella C, Colcher A, Jennings D, Nance M, Bressman S, Scott WK, Tanner C, Mickel S, Rezak M, Novak KE, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Clark LN, Marder K. Olfaction in Parkin heterozygotes and compound heterozygotes: the CORE-PD study. Neurology 2011 Jan 25;76(4):319-26 PMID 21205674
  8. Caccappolo E, Alcalay RN, Mejia-Santana H, Tang MX, Rakitin B, Rosado L, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner CM, Mickel SF, Andrews HF, Waters C, Fahn S, Cote LJ, Frucht S, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer RF, Marsh L, Hiner B, Siderowf AD, Ross BM, Verbitsky M, Kisselev S, Ottman R, Clark LN, Marder KS. Neuropsychological Profile of Parkin Mutation Carriers with and without Parkinson Disease: The CORE-PD Study. J Int Neuropsychol Soc 2011 Jan;17(1):91-100 PMID 21092386
  9. Alcalay RN, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Ross BM, Verbitsky M, Kisselev S, Louis ED, Comella C, Colcher A, Jennings D, Nance MA, Bressman SB, Scott WK, Tanner C, Mickel S, Andrews H, Waters C, Fahn S, Cote L, Frucht S, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Ottman R, Marder K, Clark LN. Frequency of known mutations in early-onset Parkinson disease: implication for genetic counseling: the consortium on risk for early onset Parkinson disease study. Arch Neurol 2010 Sep;67(9):1116-22 PMID 20837857
  10. Marder KS, Tang MX, Mejia-Santana H, Rosado L, Louis ED, Comella CL, Colcher A, Siderowf AD, Jennings D, Nance MA, Bressman S, Scott WK, Tanner CM, Mickel SF, Andrews HF, Waters C, Fahn S, Ross BM, Cote LJ, Frucht S, Ford B, Alcalay RN, Rezak M, Novak K, Friedman JH, Pfeiffer RF, Marsh L, Hiner B, Neils GD, Verbitsky M, Kisselev S, Caccappolo E, Ottman R, Clark LN. Predictors of parkin mutations in early-onset Parkinson disease: the consortium on risk for early-onset Parkinson disease study. Arch Neurol 2010 Jun;67(6):731-8 PMID 20558392
  11. Alcalay RN, Mejia-Santana H, Tang MX, Rakitin B, Rosado L, Ross B, Verbitsky M, Kisselev S, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner C, Mickel SF, Andrews HF, Waters CH, Fahn S, Cote LJ, Frucht SJ, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Ottman R, Clark LN, Marder KS, Caccappolo E. Self-report of cognitive impairment and mini-mental state examination performance in PRKN, LRRK2, and GBA carriers with early onset Parkinson's disease. J Clin Exp Neuropsychol 2010 Aug;32(7):775-9 PMID 20182943
  12. Alcalay RN, Mejia-Santana H, Tang MX, Rosado L, Verbitsky M, Kisselev S, Ross BM, Louis ED, Comella CL, Colcher A, Jennings D, Nance MA, Bressman S, Scott WK, Tanner C, Mickel SF, Andrews HF, Waters CH, Fahn S, Cote LJ, Frucht SJ, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Caccappolo E, Ottman R, Clark LN, Marder KS. Motor phenotype of LRRK2 G2019S carriers in early-onset Parkinson disease. Arch Neurol 2009 Dec;66(12):1517-22 PMID 20008657
  13. Hiner BC, Molnar GF, Kopell BH. Movement Disorders: Anatomy and Physiology Relevant to Deep Brain Stimulation. In: Neuromodulation for Movement Disorders, Ed. Krames in press 2009, Elsevier, London
  14. LeWitt PA, Guttman M, Tetrud JW, Tuite PJ, Mori A, Chaikin P, Sussman NM, Hiner BC; 6002-US-005 Study Group. Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces "off" time in Parkinson's disease: a double-blind, randomized, multicenter clinical trial (6002-US-005).
    Ann Neurol. 2008 Mar;63(3):295-302.
  15. Hiner BC. Differential diagnosis of Parkinson's disease: a new blood test? Clin Med Res 2006 Dec;4(4):246-7 PMID 17210972
  16. Hiner BC.  Valsalva maneuver. Clin Med Res 2005 May;3(2):55; author reply 55 PMID 16012118
  17. Li YJ, Hauser MA, Scott WK, Martin ER, Booze MW, Qin XJ, Walter JW, Nance MA, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Small GW, Mastaglia F, Haines JL, Pericak-Vance MA, Vance JM. Apolipoprotein E controls the risk and age at onset of Parkinson disease. Neurology 2004 Jun 8;62(11):2005-9 PMID 15184605
  18. Li YJ, Oliveira SA, Xu P, Martin ER, Stenger JE, Scherzer CR, Hauser MA, Scott WK, Small GW, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Goetz CG, Mastaglia F, Middleton LT, Roses AD, Saunders AM, Schmechel DE, Gullans SR, Haines JL, Gilbert JR, Vance JM, Pericak-Vance MA, Hulette C, Welsh-Bohmer KA. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease. Hum Mol Genet 2003 Dec 15;12(24):3259-67 PMID 14570706
  19. Oliveira SA, Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons KE, Pahwa R, Stern MB, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Scott BL, Goetz CG, Small GW, Mastaglia FL, Stajich JM, Zhang F, Booze MW, Reaves JA, Middleton LT, Haines JL, Pericak-Vance MA, Vance JM, Martin ER. Association study of Parkin gene polymorphisms with idiopathic Parkinson disease. Arch Neurol 2003 Jul;60(7):975-80 PMID 12873854
  20. Oliveira SA, Scott WK, Martin ER, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Ondo WG, Allen FH Jr, Scott BL, Goetz CG, Small GW, Mastaglia F, Stajich JM, Zhang F, Booze MW, Winn MP, Middleton LT, Haines JL, Pericak-Vance MA, Vance JM. Parkin mutations and susceptibility alleles in late-onset Parkinson's disease. Ann Neurol 2003 May;53(5):624-9 PMID 12730996
  21. van der Walt JM, Martin ER, Scott WK, Zhang F, Nance MA, Watts RL, Hubble JP, Haines JL, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW, Mastaglia F, Roses AD, Stajich JM, Booze MW, Fujiwara K, Gibson RA, Middleton LT, Scott BL, Pericak-Vance MA, Vance JM. Genetic polymorphisms of the N-acetyltransferase genes and risk of Parkinson's disease. Neurology 2003 Apr 8;60(7):1189-91 PMID 12682333
  22. van der Walt JM, Nicodemus KK, Martin ER, Scott WK, Nance MA, Watts RL, Hubble JP, Haines JL, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW, Mastaglia F, Stajich JM, McLaurin AC, Middleton LT, Scott BL, Schmechel DE, Pericak-Vance MA, Vance JM. Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet 2003 Apr;72(4):804-11 PMID 12618962
  23. Greenlee AR, Burmester JK, Hiner BC. Pesticide exposure, host susceptibility factors and risk of Parkinson's disease: an introduction to a work in progress. WMJ 2002;101(5):20-4 PMID 12239976
  24. Li YJ, Scott WK, Hedges DJ, Zhang F, Gaskell PC, Nance MA, Watts RL, Hubble JP, Koller WC, Pahwa R, Stern MB, Hiner BC, Jankovic J, Allen FA Jr, Goetz CG, Mastaglia F, Stajich JM, Gibson RA, Middleton LT, Saunders AM, Scott BL, Small GW, Nicodemus KK, Reed AD, Schmechel DE, Welsh-Bohmer KA, Conneally PM, Roses AD, Gilbert JR, Vance JM, Haines JL, Pericak-Vance MA. Age at onset in two common neurodegenerative diseases is genetically controlled. Am J Hum Genet 2002 Apr;70(4):985-93 PMID 11875758
  25. Martin ER, Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Ribble RC, Booze MW, Rogala A, Hauser MA, Zhang F, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Pericak-Vance MA, Vance JM. Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. JAMA 2001 Nov 14;286(18):2245-50 PMID 11710889
  26. Scott WK, Nance MA, Watts RL, Hubble JP, Koller WC, Lyons K, Pahwa R, Stern MB, Colcher A, Hiner BC, Jankovic J, Ondo WG, Allen FH Jr, Goetz CG, Small GW, Masterman D, Mastaglia F, Laing NG, Stajich JM, Slotterbeck B, Booze MW, Ribble RC, Rampersaud E, West SG, Gibson RA, Middleton LT, Roses AD, Haines JL, Scott BL, Vance JM, Pericak-Vance MA. Complete genomic screen in Parkinson disease: evidence for multiple genes. JAMA 2001 Nov 14;286(18):2239-44 PMID 11710888
  27. http://www.ncbi.nlm.nih.gov/pubmed/?term=11710888
  28. Hiner BC. Autonomic Complications of Parkinson's Disease. Parkinson's Disease and Movement Disorders: Diagnosis and Treatment for the Practicing Physician. Humana Press 2000:161-174
  29. Hiner BC. Too many treatments for Parkinson's disease: another look. WMJ 2000 Nov;99(8):4-5 PMID 11149259
  30. Hiner BC, Earnhart M. Ropinirole as compared with levodopa in Parkinson's disease. N Engl J Med 2000 Sep 21;343(12):884; author reply 885 PMID 11001684
  31. Scott WK, Yamaoka LH, Stajich JM, Scott BL, Vance JM, Roses AD, Pericak-Vance MA, Watts RL, Nance M, Hubble J, Koller W, Stern MB, Colcher A, Allen FH Jr, Hiner BC, Jankovic J, Ondo W, Laing NG, Mastaglia F, Goetz C, Pappert E, Small GW, Masterman D, Haines JL, Davies TL. The alpha-synuclein gene is not a major risk factor in familial Parkinson disease. Neurogenetics 1999 Sep;2(3):191-2 PMID 10541595
  32. Madden K, Hiner B, Neal J. Surgical therapy of Parkinson's disease. WMJ 1998 Oct;97(9):39-41 PMID 9810256
  33. Jacobson DM, Hiner BC. Asymptomatic autonomic and sweat dysfunction in patients with Adie's syndrome. J Neuroophthalmol 1998 Jun;18(2):143-7 PMID 9621272
  34. Mickel SF, Broste SK, Hiner BC. Lack of overlap in genetic risks for Alzheimer's disease and Parkinson's disease. Neurology 1997 Apr;48(4):942-9 PMID 9109882
  35. Hutton JT, Koller WC, Ahlskog JE, Pahwa R, Hurtig HI, Stern MB, Hiner BC, Lieberman A, Pfeiffer RF, Rodnitzky RL, Waters CH, Muenter MD, Adler CH, Morris JL. Multicenter, placebo-controlled trial of cabergoline taken once daily in the treatment of Parkinson's disease. Neurology 1996 Apr;46(4):1062-5 PMID 8780092
  36. Jankovic J, Gilden JL, Hiner BC, Kaufmann H, Brown DC, Coghlan CH, Rubin M, Fouad-Tarazi FM. Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine. Am J Med 1993 Jul;95(1):38-48 PMID 7687093
  37. Wilkie PJ, Ahmann PA, Hardacre J, LaPlant RJ, Hiner BC, Weber JL. Application of microsatellite DNA polymorphisms to linkage mapping of Tourette syndrome gene(s). Adv Neurol 1992;58:173-80 PMID 1357938
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