Neurology

EmailEmail    |   Bookmark Page Bookmark  |   RSS Feeds RSS  |   Print Page Print  

Carol Everson, PhDCarol A. Everson, PhD

Professor, Department of Neurology 
Professor, Department of Cell Biology, Neurobiology, and Anatomy

Specialty: Sleep Physiology Research

Sub-Specialty:

  • Biological basis of behavior
  • Neuroendocrinology
  • Neuroimmunology

Education:

  • B.A., University of Wisconsin, LaCrosse, WI, 1979
  • Postgraduate courses, University of Wisconsin-Madison; Management in private industry, 1979-1982
  • Ph.D., University of Chicago, Chicago, Illinois, 1987

Training/Positions:

  • Staff Fellow, Clinical Psychobiology Branch, Intramural Research Program, National Institutes of Health, Bethesda, Maryland, 1988 -1991.
  • Senior Staff Fellow, Clinical Psychobiology Branch, Intramural Research Program, The National Institutes of Health, Bethesda, Maryland, 1991 - 1995.
  • Assistant professor, Department of Physiology, University of Tennessee Medical College and Health Sciences Center, Memphis, Tennessee, 1995-2000.

Societies:
 

  • Member, Sleep Research Society, Associated Professional Sleep Societies, 1983-present
  • Member, European Sleep Research Society, 1994-present
  • Member, American Physiological Society, 1997-present
  • Member, Center for Neuroscience, University of Tennessee, 1996-2000

Awards/Honors:

  • National Research Service Award, Department of Psychiatry, University of Chicago, 1983 - 1987
  • Joseph Kelly Memorial Award for Highest Standards in Quality of Research, University of Chicago, 1987

Brief Clinical/Research Interest Statement:

Our long-term goal is to determine how restriction of sleep affects functions of cells, processes, and systems in ways that promote disease or impede recuperation, and conversely how recovery of sleep specifically increases resistance to disease. We have shown that sleep deprivation results in a unique set of health impairments believed to contribute to co-morbid disease conditions and shortened longevity in humans. The clinicopathological course of sleep deprivation in the laboratory rat is marked by metabolic derangement that is manifested by a robust appetite and increased food consumption without weight gain. Sleep deprivation decreases resistance to infectious disease, and this is manifested by failure to eradicate opportunistic microorganisms and their toxins despite activation of certain components of the immune system. Circulating anabolic hormones are suppressed by sleep deprivation due to altered regulation by brain mechanisms in ways expected to decrease resistance to disease. Despite eventual severe health impairments in rats due to sleep deprivation, the impairments are highly reversible when sleep is permitted, pointing to biochemical changes as mediators of a toxic-like state. Our recent findings provide evidence that uncompensated oxidative stress is a major pathogenic factor induced by sleep deprivation, pointing therefore to putative biochemical mediation. We are working to discover the causal relationships between oxidative stress and its sequelae and alterations of mechanisms responsible for integrity of immune, hormonal, and metabolic systems that operate abnormally during sleep deprivation.

 

 

 

Research Support

Project: Physiology of sleep deprivation
Source: NIH Intramural Research Program
Role: Principal Investigator
Dates: January 1, 1988 - June, 1995

Project: Hormonal mediation of sleep deprivation pathology
Source: University of Tennessee Medical Group
Role: Principal Investigator
Dates: December 1, 1996 – November 30, 1997

Project: Central nervous system manifestations of thyroid hormone disease: Implications for sleep regulation and function.
Source: Clinical Research Center Project, funded by a NIH program award, University of Tennessee, Memphis
Role: Principal Investigator
Date: May, 1996 - April, 2000

Project: Neurobiology of Sleep Deprivation: Impaired Host Defenses
Source: NIH, National Institute of Heart, Lung & Blood
Role: Principal Investigator
Dates: April 1, 1997 - March 31, 2003

Project: Neuroendocrine Abnormalities Induced by Sleep Deprivation
Source: NIH, National Institute of Neurological Disorders & Stroke
Role: Principal Investigator
Dates: July 1, 1999 - May 31, 2004

Project: Sleep Fragmentation Effects on Murine CII-Induced Arthritis
Source: NIH, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Role: Co-Principal Investigator with Arnold Postlethwaite, University of Tennessee, Memphis, TN
Dates: September 01, 2002 – August 31, 2005

Project: Restricted Sleep: Modification of adiposity and adipose tissue composition
Source: NIH, National Heart, Lung & Blood Institute
Role: Principal Investigator
Dates: September 12, 2006 – July 31, 2011

Project: Oxidative stress responses to loss and recovery of sleep
Source: NIH, National Heart, Lung & Blood Institute
Role: Principal Investigator
Dates: May 1, 2007 - March 31, 2013


Publications:

Original Publications 

  1. Everson CA, Folley AE, Toth, JM. Chronically inadequate sleep results in abnormal bone formation and abnormal bone marrow in rats. Exp. Biol. Med. (in press)
  2. Everson CA, Szabo A. Repeated exposure to severely limited sleep results in distinctive and persistent physiological imbalances in rats. PLoS One 2011;6(8):e22987 PMID 21853062
  3. Everson CA, Szabo A. Recurrent restriction of sleep and inadequate recuperation induce both adaptive changes and pathological outcomes. Am J Physiol Regul Integr Comp Physiol 2009 Nov;297(5):R1430-40 PMID 19692662
  4. Everson CA, Thalacker CD, Hogg N. Phagocyte migration and cellular stress induced in liver, lung, and intestine during sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 2008 Dec;295(6):R2067-74 PMID 18945949
  5. Everson CA. Clinical assessment of blood leukocytes, serum cytokines, and serum immunoglobulins as responses to sleep deprivation in laboratory rats. Am J Physiol Regul Integr Comp Physiol 2005 Oct;289(4):R1054-63 PMID 15947073
  6. Everson CA, Laatsch CD, Hogg N. Antioxidant defense responses to sleep loss and sleep recovery. Am J Physiol Regul Integr Comp Physiol 2005 Feb;288(2):R374-83 PMID 15472007
  7. Everson CA, Crowley WR. Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats. Am J Physiol Endocrinol Metab 2004 Jun;286(6):E1060-70 PMID 14871886
  8. Everson CA, Nowak TS Jr. Hypothalamic thyrotropin-releasing hormone mRNA responses to hypothyroxinemia induced by sleep deprivation. Am J Physiol Endocrinol Metab 2002 Jul;283(1):E85-93 PMID 12067847
  9. Everson CA, Toth LA. Systemic bacterial invasion induced by sleep deprivation. Am J Physiol Regul Integr Comp Physiol 2000 Apr;278(4):R905-16 PMID 10749778
  10. Everson CA. Functional consequences of sustained sleep deprivation in the rat. Behav Brain Res 1995 Jul-Aug;69(1-2):43-54 PMID 7546317
  11. Everson CA, Reed HL. Pituitary and peripheral thyroid hormone responses to thyrotropin-releasing hormone during sustained sleep deprivation in freely moving rats. Endocrinology 1995 Apr;136(4):1426-34 PMID 7895653
  12. Everson CA, Smith CB, Sokoloff L. Effects of prolonged sleep deprivation on local rates of cerebral energy metabolism in freely moving rats. J Neurosci 1994 Nov;14(11 Pt 2):6769-78 PMID 7965078
  13. Everson CA. Sustained sleep deprivation impairs host defense. Am J Physiol 1993 Nov;265(5 Pt 2):R1148-54 PMID 8238617
  14. Mudd CP, Everson CA. A 16-channel microcomputer-controlled thermistor temperature measurement system for use in physiological studies (35 to 40 ºC). In: Temperature, Its Measurement and Control in Science and Industry (American Institute of Physics, Vol. 6, Pt. 2), 1992;1003-1007.
  15. Everson CA, Wehr TA. Nutritional and metabolic adaptations to prolonged sleep deprivation in the rat. Am J Physiol 1993 Feb;264(2 Pt 2):R376-87 PMID 8447493
  16. Kushida CA, Everson CA, Suthipinittharm P, Sloan J, Soltani K, Bartnicke B, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: VI. Skin changes. Sleep 1989 Feb;12(1):42-6 PMID 2928624
  17. Everson CA, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: III. Total sleep deprivation. Sleep 1989 Feb;12(1):13-21 PMID 2928622
  18. Benca RM, Kushida CA, Everson CA, Kalski R, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: VII. Immune function. Sleep 1989 Feb;12(1):47-52 PMID 2784583
  19. Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA. Sleep deprivation in the rat: I. Conceptual issues. Sleep 1989 Feb;12(1):1-4 PMID 2648532
  20. Everson CA, Gilliland MA, Kushida CA, Pilcher JJ, Fang VS, Refetoff S, Bergmann BM, Rechtschaffen A. Sleep deprivation in the rat: IX. Recovery. Sleep 1989 Feb;12(1):60-7 PMID 2538911
  21. Bergmann BM, Everson CA, Kushida CA, Fang VS, Leitch CA, Schoeller DA, Refetoff S, Rechtschaffen A. Sleep deprivation in the rat: V. Energy use and mediation. Sleep 1989 Feb;12(1):31-41 PMID 2538910
  22. Bergmann BM, Kushida CA, Everson CA, Gilliland MA, Obermeyer W, Rechtschaffen A. Sleep deprivation in the rat: II. Methodology. Sleep 1989 Feb;12(1):5-12 PMID 2928625
  23. Rechtschaffen A, Bergmann BM, Everson CA, Kushida CA, Gilliland MA. Sleep deprivation in the rat: X. Integration and discussion of the findings. Sleep 1989 Feb;12(1):68-87 PMID 2648533

 

Books, Chapters and Reviews

  1. Bergmann, B.: Everson, C.; Gilliland, M.; Kushida, C.; Obermeyer, W.; Pilcher, J.; Prete, F.; Rechtschaffen, A. Sleep deprivation and thermoregulation. In: Horne, J., ed. Sleep '88: Proceedings of the 9th European Congress of Sleep Research. New York: Gustav Fischer Verlag, 1989:91-95.
  2. Everson CA. Functional consequences of sustained sleep deprivation in the rat. Behavioural Brain Research, 69:43-54; 1995.
  3. Everson CA. Sleep deprivation and the immune system. In: Pressman MR, Orr WC, eds. Understanding Sleep: Evaluation and Treatment of Sleep Disorders. Washington, D.C.: American Psychological Association, 1997, pp. 401-424.
  4. Everson CA. Clinical manifestations of sleep deprivation. In: Schwartz WJ, ed. Monographs in Clinical Neuroscience. Basal: Karger, 1997, vol 15, pp. 34-59.
  5. Everson CA. The Neuroscience and Endocrinology of Fibromyalgia: Physiological Consequences of Sleep Deprivation. J. of Musculoskeletal Pain, 6(3):93-101;1998.
  6. Everson CA. Animal models of sleep deprivation/restriction. In: Sleep Research Society, Basics of Sleep Guide. Westchester, IL: Sleep Research Society, 2005, pp. 31-36.
  7. Everson C. Sleep Deprivation/Restriction. In: Slide Sets to Accompany the SRS Basics of Sleep Guide, edited by Amlaner CJ and Buxton OM. Westchester, Illinois: The Sleep Research Society Educational Programs, 2007. www.sleepresearchsociety.org.
webmaster@mcw.edu
© 2014 Medical College of Wisconsin
Page Updated 06/17/2014