Neurology

Christopher R. Butson, Ph.D.

Associate Professor of Neurology & Neurosurgery

Specialty: Adult Neurology

Sub-Specialty:

• Neural Engineering
• Deep brain stimulation (DBS)
• Cortical Stimulation
• Bioelectric Field Modeling
• Computational Neuroscience

Education:

• BS, Mechanical Engineering, University of Maryland
• MS, Electrical Engineering, George Washington University
• PhD, Biomedical Engineering, University of Utah

Training:

• Research Associate, Cleveland Clinic Foundation, Dept. of Biomedical Engineering, 2006 – 2008
• Postdoctoral Fellow, Cleveland Clinic Foundation, Dept. of Biomedical Engineering, 2004 – 2005
• Neuroinformatics Course 2005, Marine Biological Laboratory, Woods Hole, MA
• Research Fellowship, Friday Harbor Laboratories, July, 2004
• Senior Systems Engineer, Lockheed Martin Corporation, 1993-1998

Professional Memberships:

• Society for Neuroscience (SFN)
• Institute of Electrical and Electronics Engineers (IEEE)

Patents & Intellectual Property:

• Co-Founder, contributing inventor and shareholder of Intelect Medical, http://www.intelectmedical.com/.
• Butson CR, Maks CB, McIntyre CC. Systems and methods for determining volume of activation for deep brain stimulation. US Patent Application filed March, 2007; European Patent No. 05794215.3-2201-US2005023672.
• Butson CR, McIntyre CC. System and method to design structure for delivering electrical energy to tissue. US Patent Application filed November, 2006.
• McIntyre CC, Butson CR. Thalamic stimulation device. US Patent Application filed June, 2006.
• McIntyre CC, Butson CR, Hall JD, Henderson JM. Brain stimulation models, systems, devices, and methods. US Patent 7,346,382 issued March 18, 2008.

Brief Clinical/Research Statement:

Dr. Butson specializes in the engineering design and clinical application of neurostimulation technology. His laboratory researches the use of deep brain stimulation (DBS) and cortical stimulation to treat movement disorders, epilepsy and other diseases. This research is conducted using a combination of human clinical studies and patient-specific computational models. The primary goals of his research are to improve the effectiveness of existing neurostimulation systems and to develop new technology to treat a broader range of patients, some of whom have few treatment options.

Publications:

Articles

• Maks CB, Butson CR, Walter BL, Vitek JL, McIntyre CC. (2008) Deep brain stimulation activation volumes and their association with neurophysiological mapping and therapeutic outcomes, J Neurol Neurosurg Psychiatry, (In Press).
• Butson CR, McIntyre CC. (2007) Current steering to control the volume of tissue activated during deep brain stimulation, Brain Stimulation, 1(1): 7-15.
• Butson CR, McIntyre CC. (2007) Differences among implanted pulse generator waveforms cause variations in the neural response to deep brain stimulation, Clin Neurophysiol, 118(8): 1889-94.
• McIntyre CC, Miocinovic S, Butson CR. (2007) Computational Analysis of Deep Brain Stimulation, Expert Review of Medical Devices, Sept 2007, Vol. 4, No. 5, Pages 615-622.
• Maks CB, Butson CR, McIntyre CC. (2007) Association of Deep Brain Stimulation Activation Volumes with Neurophysiological Mapping and Therapeutic Outcomes, J Neurol Neurosurg Psychiatry (In Press).
• Butson CR, Cooper SE, Henderson JM, McIntyre CC. (2007) Patient-specific analysis of the volume of tissue activated during deep brain stimulation, NeuroImage, 34(2):661-670.
• Butson CR, Noecker AM, Maks CB, McIntyre CC, (2007) StimExplorer: Deep Brain Stimulation Parameter Selection Software System, Acta Neurochir Suppl, 97(2): 569-574.
• Miocinovic S, Maks CB, Noecker AM, Butson CR, McIntyre C.C., (2007) Cicerone: Stereotactic Neurophysiological Recording and Deep Brain Stimulation Electrode Placement Software System, Acta Neurochir Suppl, 97(2): 561–567.
• Butson CR, McIntyre CC. (2006) Role of electrode design on volume of tissue activated during deep brain stimulation, J Neural Eng, March; 3(1):1-8. Chosen by IOP Select for a high degree of novelty and significant impact on future research.
• Butson CR, Maks CB, McIntyre CC. (2006) Sources and effects of electrode impedance during deep brain stimulation, Clin Neurophysiol, Feb;117(2):447-54.
• Miocinovic S, Parent M, Butson CR, Hahn P, Russo GS, Jerrold L. Vitek JL, McIntyre CC. (2006) Computational analysis subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation, J Neurophysiol, 96:1569-1580.
• Butson CR, McIntyre CC. (2005) Tissue and electrode capacitance reduce neural activation volumes during deep brain stimulation, Clin Neurophysiol, Oct;116(10):2490-500.
• Butson CR, Clark GA, (2008) Random noise paradoxically improves light intensity coding in Hermissenda photoreceptor network, J Neurophysiol, 99:146-154.
• Butson CR, Clark GA, (2008) Mechanisms of noise-induced performance improvement in Hermissenda photoreceptor network, J Neurophysiol, 99:155-165.
• Butson CR, Miller IO, Normann RA, Clark GA, (2008) Selective activation in a histologically derived model of sciatic nerve, J Neural Eng (In preparation).
• Schultz, LM, Butson, CR, and Clark, GA Post-light potentiation at type B to A photoreceptor connections in Hermissenda, Neurobiology of Learning and Memory, 2001 Jul;76(1):7-32. Peer Reviewed Workshop Papers
• Butson CR, Copper SE, Henderson JM, McIntyre CC. (2006) Predicting the effects of deep brain stimulation with diffusion tensor based electric field models, Med Image Comput Comput Assist Interv, 9(Pt 2):429-37.

Book Chapters

• Kopell BH, Machado AG, Butson CR, (2008) Stimulation technology in functional neurosurgery, In: Textbook of Stereotactic and Functional Neurosurgery, 2nd Edition, AM Lozano, PL Gildenberg, RR Tasker (eds) Springer.
• McIntyre CC, Butson CR, Walter BL, Vitek JL, (2005) Rationale for movement disorders surgery, In: Movement Disorder Surgery – The Essentials, RA Bakay (ed) Thieme.