Neurology

Diane S. Book, MD

Associate Professor of Neurology
Medical Director, Froedtert/Medical College Stroke Program

Specialty: Adult Neurology

Sub Specialty: 

• Hyperacute Stroke Treatment
• Cerebrovascular Disease
• Dementia

Education:

• Doctor of Medicine, Medical College of Wisconsin, Milwaukee, WI, 1991

Postgraduate Training and Fellowship Appointments:

• Resident, Neurology, Medical College of Wisconsin Affiliated Hospitals, Milwaukee, WI, 1991-1995.
• Fellow, Behavioral Neurology Fellowship, Stroke/Dementia, Medical College of Wisconsin, Milwaukee, WI, 1995-1996.

Societies:

• American Medical Association
• American Heart Association Stroke Council
• American Academy of Neurology
• Wisconsin Stroke Committee, panel Chairwoman

Awards/Honors:

• Education
  • Alpha Omega Alpha Medical Honor Society
  • American Medical Women's Association Scholastic Achievement Award
  • Phi Beta Kappa
  • Phi Kappa Phi
• Best Doctors 2008, recognized by selection of other physicians, reflects top 5% of physicians nationally
• Top Doctors 2008, awarded in Milwaukee Magazine by survey of other Wisconsin physicians
• Froedtert & Medical College Stroke & Neurovascular Program receives Joint Commission Primary Stroke Center Certification 2006-present, and American Heart Association Performance Achievement Awards for clinical care quality 2007, 2008

Brief Clinical/Research Interest Statement

• Ischemic Stroke Evaluation and Management
• Hyperacute Stroke
• Stroke Education
• Stroke Care Quality
• Dementias

Current and Previous Research Projects

• Secondary Prevention of Small Subcortical Strokes (SPS3); NIH/NINDS , local Principal Investigator

Selected Publications

Original Publications:

1. Tanne, D. , Bates., V., Verro., P., Kasner, S., Binder, J.R., Patel, S., Mansbach, H., Dalet, S., Schultz, L., Karanjia, P., Scott, P., Dayno, J., Vereczey-Porter, K., Benesch, C., Book, D., Coplin, W., Dulli, D., Levine, S. & the t-PA Stroke Survey Group (1999). Initial clinical experience with IV tissue plasminigen activator for acute ischemic stroke: A multicenter survey. Neurology, 53 (2), 424-427.
2. Tanne, D. et al. , and the tPA Stroke Survey Group (2000). Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke in Patients Aged 80 Years and Older: The tPA Stroke Survey Experience. Stroke, 31, 370-375.
3. Albers, G.W. et al. (2000). Intravenous tissue-type plasminogen activator for treatment of acute stroke: The Standard Treatment with Alteplase to Reverse Stroke (STARS) Study. JAMA, 283, 1145-1150.
4. Varelas PN, Sinson G, Rand S, Book D. Clipping the Eagle's wings: treatment of an unusual cause of transient cerebral ischemia. Neurology. 2005 Jan 25;64(2):393-4.
5. Amarenco A., and the SPARCL Investigators et al., High-Dose Atorvastatin after Stroke or Transient Ischemic Attack, NEJM, 2006; 355 :549-59. (SPARCL study)

Books, Chapters and Reviews:

1. Book, D.S., & Porth, C.: Chapter 50 Disorders of Brain Function. Pathophysiology: Concepts of Altered Health States. 5th edition, Lippincott –Raven Publishers, 2000.
2. Book, Diane, Muntz, Martin , JAradeh, Safwan, Neurology Chapter from Concise Textbook of Medicine for Students, 5th edition, Torre, Lamb, VanRuiswyk, Schapira, Kochar, editors, Lippincott, Williams & Wilkins, 2009.
3. Journal Reviewer: Cerebrovascular Diseases, Karger Publishers; American Stroke Association International Stroke Conference 2008