Neurology

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Einat LibenthalEinat Liebenthal, DSc

Associate Professor of Neurology
Director, Speech Imaging Lab

Specialty: Adult Neurology

Sub-Specialty:

  • Speech Perception
  • Neuroimaging

Education:

  • Biology, Hebrew University, Jerusalem, Israel, 1990
  • MSc Neurophysiology, Hebrew University, Jerusalem, Israel, 1993
  • DSc Neurophysiology, Technion I.I.T., Haifa, Israel, 1997

Training:

  • Postdoctoral Research Fellow, Department of Neuroscience, Albert Einstein College of Medicine, NY, NY.  H.G. Jr. Vaughan, MD and D. Kurtzberg, PhD; advisors: 1997-1999
  • Postdoctoral Research Fellow, Department of Neurology, Medical College of Wisconsin, J.R. Binder, MD; advisor: 1999-2000.

Societies:

  • Cognitive Neuroscience Society, 1999- present
  • Association for Research in Otolaryngology, 1999- present
  • Acoustical Society of America, 1999- present
  • International Electric Response Audiometry Study Group, 1996-2000
  • Organization for Human Brain Mapping, 1999- present

Awards/Honors:

  • Israel Society for Clinical Neurophysiology Prize for best presentation, 1995
  • King Solomon's Prize for best paper in Neuroethology, Hebrew University, 1994
  • Julius and Dorothea Harband Doctoral Fellowship, Technion, I.I.T, 1993-1997
  • BSc Biology, Cum Laude, 1990

Brief Clinical/Research Interest Statement:

Research in the Speech Imaging Lab focuses on the neurophysiological basis of speech perception and in particular on the neural mechanisms underlying the representation of sublexical phonemic information in the temporal cortex of healthy adults. Phonemic perception emerges when the acoustically rich, diverse and continuously varying speech signals are represented as a limited set of discrete, learned phonemic categories. This abstraction process results in relatively better discrimination across than within phoneme categories, a phenomenon well-known as categorical perception of speech. A main research aim is to determine whether the characteristic pattern of increased response in left ventral temporal regions during speech perception is related to the categorical nature of this process rather than strictly to its relevance for language.

Current and Previous Grants

  • 2001, "Simultaneous FMRI/ERP Measures of Speech Perception," NIDCD R21 DC04880 (E. Liebenthal, P.I.). (2001-2003). 50% effort, Principal Investigator.
  • 2000, "Functional MRI of Human Brain Language Systems," NINDS RO1 NS33576 (J.R. Binder, P.I.). (2000-2005). 50% effort; Co- Investigator.
  • 1997, "Electrophysiological manifestations of phonetic processing deficits," NIDCD Center Grant (R Ruben, Director, D. Kurtzberg, P.I.). Award Period: 1997-2002. $100% effort, Research Associate.
  • 1996, "Electrophysiology of echoic sound perception in humans," (H. Pratt, P.I). Agency: Israel Science Foundation. Award period: 1996-1999. 100% effort, Co-Investigator.

Publications:

  1. Sabri M, Humphries C, Verber M, Mangalathu J, Desai A, Binder JR, Liebenthal E. Perceptual Demand Modulates Activation of Human Auditory Cortex in Response to Task-irrelevant Sounds. J Cogn Neurosci 2013 May 6: PMID 23647558
  2. Mangalathu-Arumana J, Beardsley SA, Liebenthal E. Within-subject joint independent component analysis of simultaneous fMRI/ERP in an auditory oddball paradigm. Neuroimage 2012 May 1;60(4):2247-57 PMID 22377443
  3. Sabri M, Humphries C, Binder JR, Liebenthal E. Neural events leading to and associated with detection of sounds under high processing load. Hum Brain Mapp 2013 Mar;34(3):587-97 PMID 22102362
  4. Liebenthal E, Desai R, Ellingson MM, Ramachandran B, Desai A, Binder JR. Specialization along the left superior temporal sulcus for auditory categorization. Cereb Cortex 2010 Dec;20(12):2958-70 PMID 20382643
  5. Humphries C, Liebenthal E, Binder JR. Tonotopic organization of human auditory cortex. Neuroimage 2010 Apr 15;50(3):1202-11 PMID 20096790
  6. Desai R, Liebenthal E, Waldron E, Binder JR. J Left posterior temporal regions are sensitive to auditory categorization. Cogn Neurosci 2008 Jul;20(7):1174-88 PMID 18284339
  7. Sabri M, Binder JR, Desai R, Medler DA, Leitl MD, Liebenthal E. Attentional and linguistic interactions in speech perception. Neuroimage 2008 Feb 1;39(3):1444-56 PMID 17996463
  8. Humphries C, Binder JR, Medler DA, Liebenthal E. Time course of semantic processes during sentence comprehension: an fMRI study. Neuroimage 2007 Jul 1;36(3):924-32 PMID 17500009
  9. Binder JR, Medler DA, Westbury CF, Liebenthal E, Buchanan L. Tuning of the human left fusiform gyrus to sublexical orthographic structure. Neuroimage 2006 Nov 1;33(2):739-48 PMID 16956773
  10. Humphries C, Binder JR, Medler DA, Liebenthal E. Syntactic and semantic modulation of neural activity during auditory sentence comprehension. J Cogn Neurosci 2006 Apr;18(4):665-79 PMID 16768368
  11. Sabri M, Liebenthal E, Waldron EJ, Medler DA, Binder JR. Attentional modulation in the detection of irrelevant deviance: a simultaneous ERP/fMRI study. J Cogn Neurosci 2006 May;18(5):689-700 PMID 16768370
  12. Binder JR, Medler DA, Desai R, Conant LL, Liebenthal E. Some neurophysiological constraints on models of word naming. Neuroimage 2005 Sep;27(3):677-93 PMID 15921937
  13. Desai R, Liebenthal E, Possing ET, Waldron E, Binder JR. Volumetric vs. surface-based alignment for localization of auditory cortex activation. Neuroimage 2005 Jul 15;26(4):1019-29 PMID 15893476
  14. Liebenthal E, Binder JR, Spitzer SM, Possing ET, Medler DA. Neural substrates of phonemic perception. Cereb Cortex 2005 Oct;15(10):1621-31 PMID 15703256
  15. Ellingson ML, Liebenthal E, Spanaki MV, Prieto TE, Binder JR, Ropella KM. Ballistocardiogram artifact reduction in the simultaneous acquisition of auditory ERPS and fMRI. Neuroimage 2004 Aug;22(4):1534-42 PMID 15275910
  16. Binder JR, Liebenthal E, Possing ET, Medler DA, Ward BD. Neural correlates of sensory and decision processes in auditory object identification. Nat Neurosci 2004 Mar;7(3):295-301 PMID 14966525
  17. Liebenthal E, Binder JR, Spitzer SM, Possing ET, Medler DA (2005). Neural substrates of phonemic perception. Cerebral Cortex, 15 (10):1621-1631.
  18. Liebenthal E, Ellingson ML, Spanaki MV, Prieto TE, Ropella KM, Binder JR. Simultaneous ERP and fMRI of the auditory cortex in a passive oddball paradigm. Neuroimage 2003 Aug;19(4):1395-404 PMID 12948697
  19. Liebenthal E, Binder JR, Piorkowski RL, Remez RE. Short-term reorganization of auditory analysis induced by phonetic experience. J Cogn Neurosci 2003 May 15;15(4):549-58 PMID 12803966
  20. Liebenthal E, Pratt H. Evidence for primary auditory cortex involvement in the echo suppression precedence effect: a 3CLT study. J Basic Clin Physiol Pharmacol 1997;8(3):181-201 PMID 9429985
  21. Liebenthal E, Uhlmann O, Camhi JM. Critical parameters of the spike trains in a cell assembly: coding of turn direction by the giant interneurons of the cockroach. J Comp Physiol A 1994 Mar;174(3):281-96 PMID 8151520
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